Homozygous mutations in CCDC34 cause male infertility with oligoasthenoteratozoospermia in humans and mice

Conclusions Our findings support that CCDC34 is crucial to the formation of sperm flagella and that biallelic deleterious mutations in CCDC34/Ccdc34 cause male infertility with oligoasthenoteratozoospermia in humans and mice.

http://jmg.bmj.com/cgi/content/short/59/7/710?rss=1

Source: Journal of Medical Genetics - June 27, 2022 Category: Genetics & Stem Cells Authors: Cong, J., Wang, X., Amiri-Yekta, A., Wang, L., Kherraf, Z.-E., Liu, C., Cazin, C., Tang, S., Hosseini, S. H., Tian, S., Daneshipour, A., Wang, J., Zhou, Y., Zeng, Y., Yang, S., He, X., Li, J., Cao, Y., Jin, L., Ray, P. F., Zhang, F. Tags: Gametes Source Type: research