BET-ting on histone proteomics in schizophrenia

Trends Neurosci. 2022 Jun 16:S0166-2236(22)00119-9. doi: 10.1016/j.tins.2022.06.001. Online ahead of print.ABSTRACTIn a recent study, Farrelly, Zheng, and colleagues used a histone proteomics approach and patient-derived neurons to show increase in histone variant H2A.Z acetylation associated with schizophrenia (SCZ). They identified the bromo- and extraterminal (BET) protein BRD4 as an H2A.Z acetylation 'reader', and showed that a BRD4 inhibitor ameliorated the SCZ-associated transcriptional signature, revealing a new candidate target for treatment.PMID:35718601 | DOI:10.1016/j.tins.2022.06.001
Source: Trends in Neurosciences - Category: Neuroscience Authors: Source Type: research