Improved understanding of protein complex offers insight into DNA replication initiation mechanism basics

(DOE/Argonne National Laboratory) A clearer understanding of the origin recognition complex -- a protein complex that directs DNA replication -- through its crystal structure offers new insight into fundamental mechanisms of DNA replication initiation. This will also provide insight into how ORC may be compromised in a subset of patients with Meier-Gorlin syndrome, a form of dwarfism in humans.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news