Molecular mechanisms of building blocks of life towards medicinal applications

Keio J Med. 2022;71(1):32. doi: 10.2302/kjm.71-002-ABST.ABSTRACTMembrane and membrane-spanning proteins, and non-coding RNA are biomolecules to play central roles in beginning of life and distinguishing higher-order eukaryotes. We have determined the structures of membrane protein-lipids complexes and non-coding RNA-protein complexes by X-ray crystallography and Cryo-EM single particle analysis, and combined with complementary functional analyses, elucidate their molecular mechanisms at atomic resolutions, to promote creating drugs and medical technologies with two venture companies.PMID:35342150 | DOI:10.2302/kjm.71-002-ABST

Source: The Keio Journal of Medicine - March 28, 2022 Category: Universities & Medical Training Authors: Osamu Nureki Source Type: research