Anti-inflammatory decurrencyclics A-B, two undescribed nor-dammarane triterpenes from triangular sea bell < em > Turbinaria decurrens < /em >

Nat Prod Res. 2022 Jun 16:1-12. doi: 10.1080/14786419.2022.2087182. Online ahead of print.ABSTRACTIntertidal triangular sea bell Turbinaria decurrens (Bory de Saint-Vincent) (family Sargassaceae) belongs to one of the largely abundant genus of marine brown alga. Bioactivity-directed chromatographic purification of the organic extract of T. decurrens afforded two new nor-dammarane triterpenoids named as decurrencyclic A-B. Decurrencyclic B showed superior attenuation properties against cyclooxygenase-2 (IC50 13.98 μM) and 5-lipoxygenase (IC50 3.02 μM) in contrast with decurrencyclic A. Decurrencyclic B showed higher inhibition potential against COX-2 than that revealed by the anti-inflammatory agent, ibuprofen (IC50 70.44 μM). The higher selectivity index of decurrencyclics (1.39-1.57) acknowledged their selective attenuation property against inducible cyclooxygenase-2. In-silico molecular modeling analysis of decurrencyclic B with the inflammatory enzymes showed least binding energy of -14.55 kcal mol-1. These reports have proven that decurrencyclic B could be a potential therapeutic lead for use against inflammatory pathogenesis.PMID:35707894 | DOI:10.1080/14786419.2022.2087182
Source: Natural Product Research - Category: Biochemistry Authors: Source Type: research