Voltage-gated Ca < sup > 2+ < /sup > channel proteins do not function as ion channels in T cells

Sci Signal. 2022 Jun 14;15(738):eabq5594. doi: 10.1126/scisignal.abq5594. Epub 2022 Jun 14.ABSTRACTCalcium (Ca2+) signaling has long been known to be crucial for T cell activation. Erdogmus et al. tested the function of voltage-gated Ca2+ channel (CaV) proteins and discovered a nonchannel function mediated by an accessory subunit but found no evidence for CaV channel activity in T cells.PMID:35700266 | DOI:10.1126/scisignal.abq5594

Source: Science Signaling - June 14, 2022 Category: Biomedical Science Authors: Michael D Cahalan Source Type: research