This Budding Scientist-Entrepreneur Puts The Girls-In-STEM Problem In New Perspective

There's no doubt that women tend to steer clear of careers in science and technology--the statistics simply don't lie. Nor is there any doubt that the persistent gender disparity in STEM (science, technology, engineering, and math) fields represents a big problem for our competitiveness as a nation as well as for individual women. But why are women underrepresented in STEM? Some say girls are deterred by an "implicit bias" that leads us to see science and math as "male" fields. Others point to research showing gender discrimination against women who apply for STEM jobs. Sara Sakowitz, a 19-year-old freshman biomedical engineering major at Columbia University and a budding entrepreneur, has her own strong views on the matter. As she wrote in the Washington Post last year: "I believe that in their earliest years, girls lose their spark--they succumb to societal hurdles and mental obstacles that have existed for as long as they can remember. Instead of imaginary genetic weaknesses, girls battle false portrayals of female scientists in the media and fight against the unconscious, unspoken rule that only men belong as the leaders of the world." And Sakowitz certainly knows a thing or two about science. Growing up in Long Island, Sakowitz told the Huffington Post in a recent interview, she used to hang out at the medical office of her parents, both pulmonologists. Later, at an all-girls private high school on Manhattan's East Side, she led the ...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Abstract Intratumoral heterogeneity of breast cancer remains a major challenge in successful treatment. Failure of cancer therapies can also be accredited to inability to systemically eradicate cancer stem cells (CSCs). Recent evidence points to the role of epithelial-mesenchymal transition (EMT) in expanding the pool of tumor cells with CSCs features. Thus, we assessed expression level as well as heterogeneity of CSCs markers in primary tumors (PT), lymph node metastasis (LNM), and circulating tumor cells (CTCs)-enriched blood fractions in order to correlate them with signs of EMT activation as well as clinicopat...
Source: Translational Oncology - Category: Cancer & Oncology Authors: Tags: Transl Oncol Source Type: research
We examined whether pomegranate extract (PE) alters characteristics of breast CSCs. Ability to grow as mammospheres is a hallmark of breast CSCs. PE inhibited mammosphere formation in two different cell lines, neoplastic mammary epithelial HMLER and breast cancer Hs578T. In addition, mammosphere-derived cells from PE treatment groups showed reduced mammosphere formation for at least two serial passages. These data indicate that PE inhibits CSC's ability to self-renew. In addition, incubation of mammospheres with PE reversed them into adherent cultures, indicating promotion of CSC differentiation. Epithelial-to-mesenchymal ...
Source: Nutrition and Cancer - Category: Cancer & Oncology Authors: Tags: Nutr Cancer Source Type: research
In this study, we found that miR-221/222 were overexpressed in highly aggressive breast cancer MDA-MB-231 cells, that are enriched in markers for epithelial-mesenchymal transition (EMT) and BCSCs, than in MCF-7 cells. Phosphatase and tensin homolog (PTEN) was confirmed to be the target of miR-221/222 in breast cancer cells. MiR-221/222 enhanced breast cancer cell growth, migration and invasion by downregulating PTEN. Importantly, both ectopic expression of miR-221/222 and PTEN knockdown increased the mammosphere formation capacity and the expression of the stemness marker ALDH1. MiR-221/222 lentivirus vector infe...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
In this study, we found that miR-221/222 were overexpressed in highly aggressive breast cancer MDA-MB-231 cells, that are enriched in markers for epithelial-mesenchymal transition (EMT) and BCSCs, than in MCF-7 cells. Phosphatase and tensin homolog (PTEN) was confirmed to be the target of miR-221/222 in breast cancer cells. MiR-221/222 enhanced breast cancer cell growth, migration and invasion by downregulating PTEN. Importantly, both ectopic expression of miR-221/222 and PTEN knockdown increased the mammosphere formation capacity and the expression of the stemness marker ALDH1. MiR-221/222 lentivirus vector infe...
Source: Chemico-Biological Interactions - Category: Molecular Biology Authors: Tags: Chem Biol Interact Source Type: research
This study, together with our previous one, provides more evidence of SH as a potential drug for breast cancer therapy. PMID: 28088791 [PubMed - as supplied by publisher]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
PARP3 controls TGFβ and ROS driven epithelial-to-mesenchymal transition and stemness by stimulating a TG2-Snail-E-cadherin axis. Oncotarget. 2016 Aug 26; Authors: Karicheva O, Rodriguez-Vargas JM, Wadier N, Martin-Hernandez K, Vauchelles R, Magroun N, Tissier A, Schreiber V, Dantzer F Abstract Several members of the Poly(ADP-ribose) polymerase (PARP) family are essential regulators of genome integrity, actively prospected as drug targets for cancer therapy. Among them, PARP3 is well characterized for its functions in double-strand break repair and mitotis. Here we report that PARP3 also plays an i...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
CONCLUSION: This study demonstrates that a small fraction of CETCs has proliferative activity. Identifying the CETC subset with cancer stem cell properties may provide more clinically useful prognostic information. Chemotherapy is the most important component in cancer therapy because it frequently reduces the number of tumorspheres. PMID: 27340862 [PubMed - as supplied by publisher]
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study teaches us that poor wound healing and wrinkling and sagging that occur in aging skin share similar mechanisms." Reduced cell cohesiveness of outgrowths from eccrine sweat glands delays wound closure in elderly skin Human skin heals more slowly in aged vs. young adults, but the mechanism for this delay is unclear. In humans, eccrine sweat glands (ESGs) and hair follicles underlying wounds generate cohesive keratinocyte outgrowths that expand to form the new epidermis. Our results confirm that the outgrowth of cells from ESGs is a major feature of repair in young skin. Strikingly, in aged s...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
ABSTRACT Cancer stem cells (CSCs) are capable of initiation and metastasis of tumors. Therefore, understanding the biology of CSCs and the interaction between CSCs and their counterpart non‐stem cells is crucial for developing a novel cancer therapy. We used CSC‐like and non‐stem breast cancer MDA‐MB‐231 and MDA‐MB‐453 cells to investigate mammosphere formation. We investigated the role of the epithelial cadherin (E‐cadherin)‐extracellular signal‐regulated kinase (Erk) axis in anoikis. Data from E‐cadherin small hairpin RNA assay and mitogen‐activated protein kinase kinase (MEK) inhibitor study show...
Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: Article Source Type: research
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Source: Journal of Cellular Biochemistry - Category: Biochemistry Authors: Tags: Article Source Type: research
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