High-throughput screening in combination with a cohort study for iodothyronine deiodinases

In conclusion, we completed HTS for DIOs and obtained attractive hit compounds. Our cohort study revealed the clinical significance of ritodrine, sildenafil, and TKIs. We hope our unique method will contribute to analyzing various targets and lists of hit compounds will promote understanding of DIOs.PMID:35695766 | DOI:10.1210/endocr/bqac090

https://pubmed.ncbi.nlm.nih.gov/35695766/?utm_source=no_user_agent&utm_medium=rs...

Source: Endocrinology - June 13, 2022 Category: Endocrinology Authors: Ichiro Yamauchi Yoriko Sakane Yukiko Okuno Taku Sugawa Takuro Hakata Haruka Fujita Kentaro Okamoto Daisuke Taura Takafumi Yamashita Keisho Hirota Yohei Ueda Toshihito Fujii Akihiro Yasoda Nobuya Inagaki Source Type: research