A step forward for stress-induced ataxia

Trends Neurosci. 2022 Jun 4:S0166-2236(22)00104-7. doi: 10.1016/j.tins.2022.05.010. Online ahead of print.ABSTRACTPatients with episodic ataxia type 2 (EA2) display attacks of severe incoordination and dystonia that can be triggered by stress. In a recent study, Snell et al. found a mechanistic pathway by which norepinephrine (NE) alters cerebellar Purkinje output to trigger attacks in a mouse model of EA2 and identified a pharmacological intervention that effectively reduces them.PMID:35672171 | DOI:10.1016/j.tins.2022.05.010
Source: Trends in Neurosciences - Category: Neuroscience Authors: Source Type: research