Avoid voriconazole in transplant patients at risk for skin cancer

SAN FRANCISCO – Voriconazole increased the risk of squamous cell carcinoma by 73% in a review of 455 lung transplant patients at the University of California, San Francisco. The increase was for any exposure to the drug after transplant (adjusted hazard ratio, 1.73; P = .03). The...
Source: Skin and Allergy News - Category: Dermatology Tags: FPN Conferences IMN Conferences SAN Conference News SN Conferences SN News FPN News FPN Dermatology FPN Oncology HOSP News Source Type: news

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In this study, we aimed to investigate the potential anti-proliferative and pro-apoptotic activities of SNG in a panel of MM cell lines (U266, IM9, MM1S, and RPMI-8226). SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. Pre-treatment of MM cells with a universal caspase inhibitor, Z-VAD-FMK, prevented SNG mediated loss of cell viability, apoptosis, and caspase activation, confirming that SNG-mediated apoptosis is caspase-dependent. The SNG-mediated apoptosis appears to be resulted from suppres...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusion Analysis of the pleiotropic effects of IL-33 on multiple immunological cells (macrophages, mastocytes), as well as neurological cells of medulla oblongata, dorsal root ganglion, antigen-induced arthritis system, carrageen, and formalin, shows that this alarmin plays curtail, yet not fully known role in mediating inflammation, especially in chronic inflammatory pulmonary diseases such as asthma, COPD, and OSA. Taken into consideration the engagement in this process, in particular of mastocytes and their secretion of CXCL2, 4, 8, and other cytokines, there is no doubt regarding the etiopathogenic role of IL-33 in...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Individuals with a history of atopic dermatitis have a higher risk of squamous cell carcinoma development
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Dermatology, Family Medicine, Internal Medicine, Allergy, Nursing, Oncology, Pathology, Pediatrics, Journal, Source Type: news
BackgroundThe use of endoscopic resection as an alternative to open surgery for sinonasal malignancies has increased in the past 20 years. MethodsThe National Cancer Database was queried for cases of sinonasal squamous cell carcinoma (SNSCC) without cervical or distant metastases that were treated surgically between 2010 and 2014. They were split into 2 groups based on surgical approach: open or endoscopic. Demographics, facility and insurance type, stage, tumor characteristics, postoperative treatment, 30‐day readmission rate, 30‐ and 90‐day mortality, and overall survival (OS) were compared between the 2 groups. Co...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSION: Although SCC with and without IP association are considered different diseases, their demographics and outcomes seem similar. Nodal metastasis was noted to be higher in the SCC cohort, which may indicate different tumor biology. Further study is warranted. PMID: 28859706 [PubMed - in process]
Source: American Journal of Rhinology and Allergy - Category: ENT & OMF Authors: Tags: Am J Rhinol Allergy Source Type: research
BackgroundThe role of human papillomavirus (HPV) in sinonasal squamous cell carcinoma (SNSCC) is not well understood. MethodsThe National Cancer Database was queried for cases of SNSCC with known HPV status. Demographics, socioeconomic variables, TNM stage, histology, grade, treatment modalities, and overall survival (OS) through 5 years were compared between HPV‐positive and HPV‐negative tumors. Cox proportional hazard regression analyses were performed. ResultsSeven hundred seventy (770) cases were identified; 526 were HPV‐negative (68.3%) and 244 (31.7%) were HPV‐positive. Patients with HPV‐positive tumors wer...
Source: International Forum of Allergy and Rhinology - Category: Allergy & Immunology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Objectives/HypothesisTo examine sociodemographic, hospital‐specific, and disease‐related characteristics in relation to outcomes in sinonasal squamous cell carcinoma (SCC). Study DesignThe National Cancer Database was queried for location codes corresponding to the nasal cavity and paranasal sinuses and histology codes representing SCC malignancy. Multivariate analyses were performed against short‐ and long‐term outcomes (overall survival, days to discharge, 30‐day readmission, and 30‐ and 90‐day mortality). ResultsThe database included 5,584 sinonasal SCC patients with an overall median survival of 53.5 mont...
Source: The Laryngoscope - Category: ENT & OMF Authors: Tags: Allergy/Rhinology Source Type: research
In this study, we investigated the association between Gal-1 expression and apoptotic T cells of gingival squamous cell carcinoma (GSCC), as well as other clinicopathological factors. Methods Immunohistochemical investigation of 80 GSCC specimens using anti-Gal-1, anti-CD3, anti-CD4, anti-CD8, anti-CD34, antipodoplanin and anticleaved caspase-3 (CC-3) antibodies was performed. Relative expression levels of CD3 and CC-3, as well as CD8 and CC-3 were assessed simultaneously by double immunostaining. Gal-1 expression and T cell apoptosis were evaluated in 6 high-power fields (3 in the tumour and 3 in the stroma). Results Ga...
Source: Journal of Clinical Pathology - Category: Pathology Authors: Tags: Immunology (including allergy) Original article Source Type: research
CONCLUSIONS: In this review, we assessed the effect of solar protection in preventing the occurrence of new cases of keratinocyte cancer. We only found one study that was suitable for inclusion. This was a study of sunscreens, so we were unable to assess any other forms of sun protection. The study addressed our prespecified primary outcomes, but not most of our secondary outcomes. We were unable to demonstrate from the available evidence whether sunscreen was effective for the prevention of basal cell carcinoma (BCC) or cutaneous squamous cell carcinoma (cSCC).Our certainty in the evidence was low because there was a lack...
Source: Cochrane Database of Systematic Reviews - Category: Journals (General) Authors: Tags: Cochrane Database Syst Rev Source Type: research
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