Chronic deep brain stimulation of the rat ventral medial prefrontal cortex disrupts hippocampal-prefrontal coherence.

Chronic deep brain stimulation of the rat ventral medial prefrontal cortex disrupts hippocampal-prefrontal coherence. Exp Neurol. 2015 Apr 1; Authors: Insel N, Pilkiw M, Nobrega JN, Hutchison WD, Takehara-Nishiuchi K, Hamani C Abstract Deep Brain Stimulation (DBS) of the subgenual cingulate gyrus (SCG) has been used to treat patients with treatment-resistant depression. As in humans, DBS applied to the ventromedial prefrontal cortex of rats induces antidepressant-like responses. Physiological interactions between structures that play a role in depression and antidepressant treatment are still unknown. The present study examined the effect of DBS on inter-region communication by measuring the coherence of local field potentials in the rat infralimbic cortex (IL; homologue of the SCG) and one of its major afferents, the ventral hippocampus (VH). Rats received daily IL DBS treatment (100μA, 90μs, 130Hz; 8h/day). Recordings were conducted in unrestrained, behaving animals on the day before treatment, after 1 and 10days of treatment, and 10days stimulation offset. VH-IL coherence in the 2-4Hz range was reduced in DBS-treated animals compared with shams after 10days, but not after only 1day of treatment. No effect of DBS was observed in the 6-10Hz (theta) range, where coherence was generally high and could be further evoked with a loud auditory stimulus. Finally, coherence was not affected by fluoxetine (10mg/kg), suggesting that the effects of DBS were ...
Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research

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PMID: 31509630 [PubMed - in process]
Source: Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Pharmacol Ther Source Type: research
PMID: 31509628 [PubMed - in process]
Source: Clinical Pharmacology and Therapeutics - Category: Drugs & Pharmacology Authors: Tags: Clin Pharmacol Ther Source Type: research
CONCLUSION: DBS of subthalamic nucleus should be seen as the most hazardous place of implantation. As a result there is a strong need of "gold standards" based on the connectivity research and closer cooperation of scientists and clinicians. PMID: 31452489 [PubMed - as supplied by publisher]
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
Neurodegeneration with brain iron accumulation (NBIA) is defined as an accumulation of iron in the basal ganglia associated with neurologic and psychiatric symptoms (1). Its estimated prevalence is 1:1,000,000 (2). Cardinal symptoms include dystonia; spasticity and/or Parkinsonian syndrome, often associated with cognitive decline (3,4); and psychiatric disorders such as obsessive-compulsive disorder (OCD) (3,5,6), depression (7), or psychosis (8).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Correspondence Source Type: research
Translational Psychiatry, Published online: 21 August 2019; doi:10.1038/s41398-019-0540-4Frontal white matter architecture predicts efficacy of deep brain stimulation in major depression
Source: Translational Psychiatry - Category: Psychiatry Authors: Source Type: research
CONCLUSIONS: Although causal assumptions are not appropriate for cross-sectional studies, the results suggest that ADL difficulties could contribute to greater stigma in PD patients with refractory motor symptoms who are candidates for DBS. PMID: 31389495 [PubMed - as supplied by publisher]
Source: Revista Brasileira de Psiquiatria - Category: Psychiatry Authors: Tags: Braz J Psychiatry Source Type: research
Publication date: Available online 2 August 2019Source: Journal of Clinical NeuroscienceAuthor(s): Özlem Saatçi, Nesrin Helvacı Yılmaz, Ali Zırh, Burak YulugAbstractDeep brain stimulation (DBS) is still a highly effective treatment option that significantly improves motor function in advanced PD. Moreover, previous findings have shown that Olfactory dysfunction (OD) has been found in a majority of patients with Parkinson's Disease (PD). Despite this, the effect of DBS on the olfactory function is not fully understood. Here we aimed to determine the effect of STN DBS on OD by evaluating the olfactory function...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
PURPOSE OF REVIEW The purpose of this article is to present current information on the phenomenology, epidemiology, comorbidities, and pathophysiology of tic disorders and discuss therapy options. It is hoped that a greater understanding of each of these components will provide clinicians with the necessary information to deliver thoughtful and optimal care to affected individuals. RECENT FINDINGS Recent advances include the finding that Tourette syndrome is likely due to a combination of several different genes, both low-effect and larger-effect variants, plus environmental factors. Pathophysiologically, increasing e...
Source: CONTINUUM: Lifelong Learning in Neurology - Category: Neurology Tags: REVIEW ARTICLES Source Type: research
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Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: Review Source Type: research
This study contributes to the first-hand primary research on the topic exploring DBS clinicians ’ views on post-DBS personality change among their patients and its underlying cause. Semi-structured interviews were conducted with sixteen clinicians from various disciplines working in Australian DBS practice for movement disorders and/or psychiatric conditions. Thematic analysis of the intervi ews revealed five primary themes: 1) types, frequency and duration of personality change, 2) causes of personality change, 3) impact on patient and family, 4) communication, comprehension and awareness, and 5) management. Clinici...
Source: Neuroethics - Category: Medical Ethics Source Type: research
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