Trial By Error: REGAIN Team Responds to Criticism with Unconvincing Defenses of Methodological Missteps
By David Tuller, DrPH In recent weeks, I have been urging The BMJ to correct a flawed University of Warwick trial of an online mental and physical health rehab program for people with prolonged symptoms at least three months after hospitalization for Covid-19. The primary outcome was health-related quality of life, assessed with a measure … Trial By Error: REGAIN Team Responds to Criticism with Unconvincing Defenses of Methodological Missteps Read More » (Source: virology blog)
Source: virology blog - April 12, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized BMJ Long Covid mcgregor REGAIN Source Type: blogs
Trial By Error: A New Study from Exeter on “ Brain Training ” for Treatment of Post-Covid Cognitive Problems
By David Tuller, DrPH The University of Exeter is now recruiting for a study of “brain training” as a treatment for prolonged cognitive dysfunction after a bout of Covid-19. I found out about this via a post on X. The post highlighted a message that had been sent to an unidentified patient from their medical … Trial By Error: A New Study from Exeter on “Brain Training” for Treatment of Post-Covid Cognitive Problems Read More » (Source: virology blog)
Source: virology blog - April 10, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized brain fog brain training Exeter Long Covid Source Type: blogs
Trial By Error: In England, Conflicts Between Families and Hospitals Threaten the Lives of Young Women with ME
By David Tuller, DrPH ME patients and advocates in England have been alarmed by a series of ongoing cases in which the families of severely ill young women have struggled to convince hospitals to fit them with feeding tubes before they starve to death. I covered a similar situation last year in a piece about … Trial By Error: In England, Conflicts Between Families and Hospitals Threaten the Lives of Young Women with ME Read More » (Source: virology blog)
Source: virology blog - April 9, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized feeding tube Maeve Millie NHS hospitals Source Type: blogs
Trial By Error: Another Letter Seeking Correction of Bogus “ Clinically Effective ” Claims from REGAIN Trial
By David Tuller, DrPH Last month, I sent a letter to Dr Abbasi, the editor-in-chief of The BMJ, about an egregious and arguably fraudulent claim in the REGAIN trial—an investigation of a Long Covid physical and mental health rehabilitation program. Several other experts co-signed the letter. The journal asked us to send in a rapid … Trial By Error: Another Letter Seeking Correction of Bogus “Clinically Effective” Claims from REGAIN Trial Read More » (Source: virology blog)
Source: virology blog - April 8, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized Abbasi BMJ Long Covid REGAIN rehabilitation Source Type: blogs
Trial By Error: My Letter to Scientific Reports about New Study of Physical Activity and Long Covid
By David Tuller, DrPH The other day I posted a blog about yet another problematic Long Covid study published by a major journal. The study concluded that physical activity (PA) can “reduce” symptoms in young women with prolonged medical complaints after Covid-19, or what the authors call post-COVID condition (PCC). The problem: the study design … Trial By Error: My Letter to Scientific Reports about New Study of Physical Activity and Long Covid Read More » (Source: virology blog)
Source: virology blog - April 7, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized Long Covid physical activity Semmelweis University Source Type: blogs
Trial By Error: Yet Another Long Covid Study with Bogus Claims Published by a Prestige Journal
By David Tuller, DrPH I’ve recently spent some time lambasting a Long Covid study in The BMJ that claimed a rehab program addressing both physical and mental health was “clinically effective”—even though the primary outcome results fell below the recommended level for what would be considered “minimal clinically important difference” on the measure in question. … Trial By Error: Yet Another Long Covid Study with Bogus Claims Published by a Prestige Journal Read More » (Source: virology blog)
Source: virology blog - April 4, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized Hungary Long Covid nature Scientific Reports Source Type: blogs
Does Herpes Simplex Virus cause Alzheimer ’ s Disease?
by Gertrud U. Rey Alzheimer’s Disease (AD) is a neurodegenerative disorder and the most common form of dementia. Although its exact cause is unclear, an increasing body of evidence suggests that an infection with herpes simplex virus (HSV) may contribute to onset of AD later in life. Both types of HSV (HSV-1 and HSV-2) infect … Does Herpes Simplex Virus cause Alzheimer’s Disease? Read More » (Source: virology blog)
Source: virology blog - April 4, 2024 Category: Virology Authors: Gertrud U. Rey Tags: Basic virology Gertrud Rey alzheimer's disease amyloid beta amyloid plaque APOE-ɛ4 association causation cognitive defect cognitive function correlation dementia herpes simplex virus herpes simplex virus 1 herpesvirus mechan Source Type: blogs
Trial By Error: My Letter to Lead REGAIN Trial Investigator Seeking Correction of Bogus Claims of Clinical Effectiveness
By David Tuller, DrPH Two weeks ago, I sent a letter to The BMJ on behalf of myself and 12 colleagues seeking a correction in a study published last month. The study, called Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): multicentre randomised controlled trial,” claimed that the intervention … Trial By Error: My Letter to Lead REGAIN Trial Investigator Seeking Correction of Bogus Claims of Clinical Effectiveness Read More » (Source: virology blog)
Source: virology blog - March 28, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized BMJ Long Covid REGAIN rehabilitation Source Type: blogs
Trial By Error: We Asked BMJ to Correct a Paper; BMJ Requested a Rapid Response; We Have Declined
Leave a Comment / By David Tuller / 24 March 2024 By David Tuller, DrPH Two weeks ago, I sent a letter to The BMJ on behalf of myself and 12 colleagues seeking a correction in a study published last month. The study, called Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN study): … Trial By Error: We Asked BMJ to Correct a Paper; BMJ Requested a Rapid Response; We Have Declined Read More » (Source: virology blog)
Source: virology blog - March 25, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized Abbasi BMJ Long Covid REGAIN Source Type: blogs
Trial By Error: David Putrino on 1) Australian Call to Scrap the Term “ Long Covid ” and 2) New Pre-Print on Sex Differences in LC
By David Tuller, DrPH Last week, just in time for Long Covid Awareness Day on Friday, the chief health officer of the Australian state of Queensland, John Gerrard, declared that the term “Long Covid” should be dropped. He based his argument on Queensland survey data suggesting that rates of prolonged disability after Covid-19 are similar … Trial By Error: David Putrino on 1) Australian Call to Scrap the Term “Long Covid” and 2) New Pre-Print on Sex Differences in LC Read More » (Source: virology blog)
Source: virology blog - March 19, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs
Trial By Error: Professor Chris Ponting on the NIH ’ s Findings and the Latest on the Genome-Wide Association Study Update
By David Tuller, DrPH When the US National Institutes of Health released its lengthy ME/CFS study last month with much fanfare and publicity, the London-based Science Media Centre asked Professor Chris Ponting, among other experts, to provide comment. The study–“Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome”–was published by Nature Communications. It included in-depth findings … Trial By Error: Professor Chris Ponting on the NIH’s Findings and the Latest on the Genome-Wide Association Study Update Read More » (Source: virology blog)
Source: virology blog - March 18, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized Source Type: blogs
Trial By Error: Guardian Columnist George Monbiot Calls Out the GET/CBT Charlatans and the Fraudulent PACE Trial
By David Tuller, DrPH In a blistering take-down published on Tuesday, Guardian columnist George Monbiot indicted Professor Sir Simon Wessely, Professor Michael Sharpe and the rest of the GET/CBT ideological brigades for their decades-long promotion of discredited theories about and bogus research into the cluster of illnesses now being called ME/CFS. Those theories and research … Trial By Error: Guardian Columnist George Monbiot Calls Out the GET/CBT Charlatans and the Fraudulent PACE Trial Read More » (Source: virology blog)
Source: virology blog - March 14, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized Guardian monbiot PACE Sharpe Wessely Source Type: blogs
Trial By Error: Letter to BMJ Seeking Correction in Study of Long Covid Physical-and-Mental Rehabilitation Program
By David Tuller, DrPH Last month, The BMJ published a study of a rehab intervention for Long Covid in which the authors made claims that were not borne out by the data. The study was called “Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-covid-19 condition (REGAIN … Trial By Error: Letter to BMJ Seeking Correction in Study of Long Covid Physical-and-Mental Rehabilitation Program Read More » (Source: virology blog)
Source: virology blog - March 11, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized BMJ Long Covid mcgregor warwick Source Type: blogs
Trial By Error: Will MAGENTA ’ s Null Results Finally End Professor Crawley ’ s Long ‘ Reign of Error ’ ?
By David Tuller, DrPH For years, Professor Esther Crawley, the University of Bristol’s methodologically and ethically challenged ME/CFS investigator, has hoovered up millions of pounds from public and private funders to support her misbegotten research. She achieved this success as a grant magnet despite abundant and easily available evidence that she was violating core principles … Trial By Error: Will MAGENTA’s Null Results Finally End Professor Crawley’s Long ‘Reign of Error’? Read More » (Source: virology blog)
Source: virology blog - March 10, 2024 Category: Virology Authors: David Tuller Tags: Uncategorized Bristol Crawley GET MAGENTA Source Type: blogs
Dogma Does Not Belong in Science
by Gertrud U. Rey According to established scientific dogma, infection of cells with HIV-1 leads to delivery of the viral capsid into the cell cytoplasm, followed by “uncoating” of the capsid to release the single-stranded RNA genome. A viral-encoded enzyme called reverse transcriptase then catalyzes the conversion of the viral RNA into a single strand … Dogma Does Not Belong in Science Read More » (Source: virology blog)
Source: virology blog - March 7, 2024 Category: Virology Authors: Gertrud U. Rey Tags: Uncategorized Source Type: blogs
