Novartis Tafinlar + Mekinist Approved by FDA for Pediatric Patients with BRAF V600E Low-Grade Glioma
New approval based on TADPOLE trial showing overall response rate (ORR) of 47% and median progression-free survival (mPFS) of 20.1 months for Tafinlar + Mekinist compared to 11% ORR and 7.4 months mPFS for standard of care1,2 Approval also... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - March 19, 2023 Category: Drugs & Pharmacology Source Type: news

Dabrafenib-Trametinib Combo Approved for Pediatric Gliomas Dabrafenib-Trametinib Combo Approved for Pediatric Gliomas
The targeted therapy combination beat chemotherapy on progression-free survival, but there was no difference in overall survival at the interim analysis.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - March 17, 2023 Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

Targeted Combination Gets FDA Nod for Pediatric Glioma
(MedPage Today) -- The FDA announced on Thursday that it has approved the BRAF inhibitor dabrafenib (Tafinlar) combined with the MEK inhibitor trametinib (Mekinist) for the treatment of pediatric patients 1 year and older with low-grade glioma... (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - March 17, 2023 Category: American Health Source Type: news

Novartis Tafinlar + Mekinist approved by FDA for pediatric patients with BRAF V600E low-grade glioma
Novartis today announced the U.S. Food and Drug Administration (FDA) granted approval for Tafinlar® (dabrafenib) + Mekinist® (trametinib) for the treatment of pediatric patients 1 year of age and older with low-grade glioma (LGG) with a BRAF V600E mutation who require systemic therapy. The FDA also approved liquid formulations of Tafinlar and Mekinist, marking the first time a BRAF/MEK inhibitor has been developed in a formulation suitable for patients as young as one year of age. (Source: World Pharma News)
Source: World Pharma News - March 17, 2023 Category: Pharmaceuticals Tags: Featured Novartis Business and Industry Source Type: news

FDA approves dabrafenib with trametinib for pediatric patients with low-grade glioma with a BRAF V600E mutation
On March 16, 2023, the Food and Drug Administration approved dabrafenib (Tafinlar, Novartis) with trametinib (Mekinist, Novartis) for pediatric patients 1 year of age and older with low-grade glioma (LGG) with a BRAF V600E mutation who require systemic therapy. The FDA also approved new oral formula (Source: FDA Center for Drug Evaluation and Research - What's New)
Source: FDA Center for Drug Evaluation and Research - What's New - March 16, 2023 Category: Drugs & Pharmacology Authors: FDA Source Type: news

VTE risk low among COVID-19 outpatients
Despite high rates of venous thromboembolism (VTE) in hospitalized COVID-1...Read more on AuntMinnie.comRelated Reading: Nomogram predicts venous thromboembolism in glioma patients Disparities found in inferior vena cava filter placement, removal Alternative method for diagnosing PE as effective as CTPA CMS releases 2022 Medicare Physician Fee Schedule final rule New PET/CT tracer effectively targets blood clots (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 14, 2023 Category: Radiology Source Type: news

Ultrasound ablation improves motor function in Parkinson's disease patients
Ultrasound ablation potentially improves motor function and reduces dyskinesi...Read more on AuntMinnie.comRelated Reading: Ultrasound renal denervation helps reduce blood pressure Contrast helps with echocardiography for aortic valve surgery CEUS better than MRI for diagnosing liver, kidney tumors Nomogram predicts venous thromboembolism in glioma patients PET tracers predict prostate patient response to HIFU (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 1, 2023 Category: Radiology Source Type: news

Ultrasound renal denervation helps reduce blood pressure
Renal denervation via ultrasound can reduce daytime ambulatory systolic bloo...Read more on AuntMinnie.comRelated Reading: Nomogram predicts venous thromboembolism in glioma patients Researchers develop ultrasound 'tornado' technique to treat blood clots POCUS achieves new heights in Mount Everest rescue AI can guide POCUS exams by novice users in the COVID ICU USPSTF advises against carotid artery stenosis screening (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 28, 2023 Category: Radiology Source Type: news

Roche launches two new antibodies to identify key clinical mutations in patients with brain cancer
Recent advances in cancer genomics have deepened the medical community ’s understanding of the molecular alterations in braintumours, more preciselysubclassifying patients into specific diagnoses.Understanding a patient ' sbraintumour mutation status in the IDH1 and ATRX genes enables more informed clinical decisions and may improve patient outcomes.The IDH1 R132H and ATRX antibodies are the latest additions to Roche ’s neuropathology portfolio, which contains 29 biomarkers.Basel, 23 February 2023 - Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today the launch of the IDH1 R132H (MRQ-67) Rabbit Monoclonal Primary Antibo...
Source: Roche Media News - February 23, 2023 Category: Pharmaceuticals Source Type: news

Nomogram predicts venous thromboembolism in glioma patients
The team, led by Chuanhao Zhang from Capital Medical University in Beijing...Read more on AuntMinnie.comRelated Reading: Nomogram assesses lymph node status better in early breast cancer Quantitative ultrasound data could help predict preterm births Wearable ultrasound patch collects cardiac images Researchers develop ultrasound 'tornado' technique to treat blood clots Combined AI system on par with radiologists for detecting breast cancer (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - February 13, 2023 Category: Radiology Source Type: news

PET imaging effective for guiding treatment of pediatric brain cancer
PET imaging can help guide treatment decisions in children with brain tumor...Read more on AuntMinnie.comRelated Reading: MR spectroscopy distinguishes recurrent brain tumors from necrosis FAPI-PET shows promise over conventional PET for identifying cancer PET tracer shows promise in imaging of brain tumors Susceptibility-weighted MRI shows brain changes in COVID-19 patients Machine learning, radiomics differentiates glioma (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - January 25, 2023 Category: Radiology Source Type: news

Extent of Tumor Resection Linked to Overall Survival in Low-Grade Glioma
TUESDAY, Jan. 17, 2023 -- For patients with diffuse low-grade glioma, the extent of surgical tumor resection (EOR) is associated with overall survival (OS), with improved OS seen with EOR≥75 percent, according to a study published online Jan. 4... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 17, 2023 Category: Pharmaceuticals Source Type: news

Rise in Cervical Cancer Mortality; Drug Active in Kids' Glioma; Vit D and Melanoma
(MedPage Today) -- A California study showed a concerning increase in cervical cancer mortality among women 65 or older, the age at which routine screening is no longer recommended. (UC Davis Comprehensive Cancer Center, Cancer Epidemiology, Biomarkers... (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - January 13, 2023 Category: Hematology Source Type: news

Extensive Resection Boosts Survival in Low-Grade Brain Tumor Extensive Resection Boosts Survival in Low-Grade Brain Tumor
Patients with diffuse low-grade glioma should undergo early, extensive resection, urge researchers reporting survival benefits from this intervention.Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)
Source: Medscape Hematology-Oncology Headlines - January 6, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

More Extensive Resection of Low-Grade Glioma Linked to Longer Survival
(MedPage Today) -- Patients with diffuse low-grade glioma (LGG) had longer overall survival (OS) if they underwent more extensive resection of the tumor compared with subtotal resection, a 20-year retrospective cohort study showed. Among 392 patients... (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - January 5, 2023 Category: Hematology Source Type: news