Leveraging seasonal influenza health worker vaccination programmes for COVID-19 vaccine Introduction: A global qualitative analysis
CONCLUSIONS: Our findings suggest a strong justification for enhanced investment in vaccination of health workers, particularly against seasonal influenza, through country-wide programmes as a foundation for pandemic preparedness and response.PMID:38531724 | DOI:10.1016/j.vaccine.2023.12.044 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Anna-Maria Volkmann Shoshanna Goldin Britney McMurren Claire Gapare Beth Anne Pratt Laura Frost Shalini Desai Source Type: research

The early safety profile of simultaneous vaccination against influenza and Respiratory Syncytial Virus (RSV) in patients with high-risk heart failure
This study indicates the safety of simultaneous influenza and RSV vaccination in high-risk HF patients, with a low incidence of mild adverse events.PMID:38531725 | DOI:10.1016/j.vaccine.2024.03.060 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Jan Biegus Leszek Szenborn Robert Zymli ński Micha ł Zakliczyński Krzysztof Reczuch Mateusz Guzik Szymon Urban Marta Rosiek-Biegus Berenika Jankowiak Gracjan Iwanek Marat Fudim Piotr Ponikowski Source Type: research

Influenza vaccination accuracy among adults: Self-report compared with electronic health record data
CONCLUSIONS: In a multistate research network across two recent influenza seasons, there was moderate concordance between EHR-based vaccination data and self-report.PMID:38531726 | DOI:10.1016/j.vaccine.2024.03.052 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Matthew F Daley Liza M Reifler Jo Ann Shoup Jason M Glanz Bruno J Lewin Nicola P Klein Elyse O Kharbanda Huong Q McLean Simon J Hambidge Jennifer C Nelson Allison L Naleway Eric S Weintraub Michael M McNeil Hilda Razzaghi James A Singleton Source Type: research

Cost-effectiveness and public health impact of typhoid conjugate vaccine introduction strategies in Bangladesh
CONCLUSIONS: We projected that nationwide TCV introduction with a catch-up campaign would substantially reduce typhoid incidence and very likely be cost saving in Bangladesh.PMID:38531727 | DOI:10.1016/j.vaccine.2024.03.035 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Christopher Weyant Yogesh Hooda Sira Jam Munira Nathan C Lo Theresa Ryckman Arif M Tanmoy Naito Kanon Jessica C Seidman Denise Garrett Samir K Saha Jeremy D Goldhaber-Fiebert Senjuti Saha Jason R Andrews Source Type: research

Reduced pertussis disease severity in infants following the introduction of pertussis vaccination of pregnant women in Spain, 2015-2019
CONCLUSIONS: Maternal pertussis vaccination in Spain led to a reduction in disease severity in the target group as compared to older infants, highlighting the need for increased efforts on educating healthcare professionals on the importance of maternal vaccinations.PMID:38531728 | DOI:10.1016/j.vaccine.2024.03.028 (Source: Vaccine)
Source: Vaccine - March 26, 2024 Category: Allergy & Immunology Authors: Andrea Parisi Olivier Nu ñez Noem í López-Perea Josefa Masa-Calles Source Type: research

Reverse engineering protection: A comprehensive survey of reverse vaccinology-based vaccines targeting viral pathogens
Vaccine. 2024 Mar 23:S0264-410X(24)00265-2. doi: 10.1016/j.vaccine.2024.02.087. Online ahead of print.ABSTRACTVaccines have significantly reduced the impact of numerous deadly viral infections. However, there is an increasing need to expedite vaccine development in light of the recurrent pandemics and epidemics. Also, identifying vaccines against certain viruses is challenging due to various factors, notably the inability to culture certain viruses in cell cultures and the wide-ranging diversity of MHC profiles in humans. Fortunately, reverse vaccinology (RV) efficiently overcomes these limitations and has simplified the i...
Source: Vaccine - March 24, 2024 Category: Allergy & Immunology Authors: Saravanaraman Ponne Rajender Kumar S M Vanmathi Raimunda S âmia Nogueira Brilhante Chinnadurai Raj Kumar Source Type: research

Global VAX: A U.S. contribution to global COVID-19 vaccination efforts, 2021-2023
Vaccine. 2024 Mar 23:S0264-410X(24)00359-1. doi: 10.1016/j.vaccine.2024.03.054. Online ahead of print.ABSTRACTIn December 2021 the U.S. Government announced a new, whole-of-government $1.8 billion effort, the Initiative for Global Vaccine Access (Global VAX) in response to the global COVID-19 pandemic. Using the foundation of decades of U.S. government investments in global health and working in close partnership with local governments and key global and multilateral organizations, Global VAX enabled the rapid acceleration of the global COVID-19 vaccine rollout in selected countries, contributing to increased COVID-19 vacc...
Source: Vaccine - March 24, 2024 Category: Allergy & Immunology Authors: Benjamin A Dahl Beth Tritter Deena Butryn Melissa Dahlke Sean Browning Richard Gelting Monica Fleming Nancy Ortiz Jacqueline Labrador Ryan Novak David Fitter Elizabeth Bell Megan McGuire Robert Rosenbaum Robert Pulwer Jolene Wun Anna McCaffrey Maisoon Cho Source Type: research

Reverse engineering protection: A comprehensive survey of reverse vaccinology-based vaccines targeting viral pathogens
Vaccine. 2024 Mar 23:S0264-410X(24)00265-2. doi: 10.1016/j.vaccine.2024.02.087. Online ahead of print.ABSTRACTVaccines have significantly reduced the impact of numerous deadly viral infections. However, there is an increasing need to expedite vaccine development in light of the recurrent pandemics and epidemics. Also, identifying vaccines against certain viruses is challenging due to various factors, notably the inability to culture certain viruses in cell cultures and the wide-ranging diversity of MHC profiles in humans. Fortunately, reverse vaccinology (RV) efficiently overcomes these limitations and has simplified the i...
Source: Vaccine - March 24, 2024 Category: Allergy & Immunology Authors: Saravanaraman Ponne Rajender Kumar S M Vanmathi Raimunda S âmia Nogueira Brilhante Chinnadurai Raj Kumar Source Type: research

Global VAX: A U.S. contribution to global COVID-19 vaccination efforts, 2021-2023
Vaccine. 2024 Mar 23:S0264-410X(24)00359-1. doi: 10.1016/j.vaccine.2024.03.054. Online ahead of print.ABSTRACTIn December 2021 the U.S. Government announced a new, whole-of-government $1.8 billion effort, the Initiative for Global Vaccine Access (Global VAX) in response to the global COVID-19 pandemic. Using the foundation of decades of U.S. government investments in global health and working in close partnership with local governments and key global and multilateral organizations, Global VAX enabled the rapid acceleration of the global COVID-19 vaccine rollout in selected countries, contributing to increased COVID-19 vacc...
Source: Vaccine - March 24, 2024 Category: Allergy & Immunology Authors: Benjamin A Dahl Beth Tritter Deena Butryn Melissa Dahlke Sean Browning Richard Gelting Monica Fleming Nancy Ortiz Jacqueline Labrador Ryan Novak David Fitter Elizabeth Bell Megan McGuire Robert Rosenbaum Robert Pulwer Jolene Wun Anna McCaffrey Maisoon Cho Source Type: research

Evaluation of bird-adapted self-amplifying mRNA vaccine formulations in chickens
In this study, we engineered two Tembusu virus (TMUV; family Flaviviridae) replicons encoding varying capsid gene lengths and compared these to the benchmark VEEV replicon in vitro. The TMUV replicon system exhibited a robust and prolonged transgene expression compared to the VEEV replicon system in both avian and mammalian cells. Moreover, the TMUV replicon induced a lesser cytopathic effect compared to the VEEV replicon RNA in vitro. DNA-launched versions of the TMUV and VEEV replicons (DREP) were also developed. The replicons successfully expressed the AIV haemagglutinin (HA) glycoproteins and the IBDV capsid protein (p...
Source: Vaccine - March 23, 2024 Category: Allergy & Immunology Authors: Jerome D G Comes Kristel Doets Thijmen Zegers Merel Kessler Irene Slits Natalia A Ballesteros Noortje M P van de Weem Henk Pouwels Monique M van Oers Marielle C W van Hulten Martijn Langereis Gorben P Pijlman Source Type: research

Exploring associations between the Big Five personality traits and cognitive ability with COVID-19 vaccination hesitancy and uptake among mothers and offspring in a UK prospective cohort study
This study sought to address these inconsistencies and explore the role of personality and cognitive ability in COVID-19 vaccination hesitancy and uptake in a prospective cohort study.METHODS: Data came from young adults (Generation-1; G1) and their mothers (Generation-0; G0) in the Avon Longitudinal Study of Parents and Children (ALSPAC). Multinomial logistic regressions, adjusting for several sociodemographic confounders, were used to explore whether personality and cognitive ability were associated with COVID-19 vaccination hesitancy and uptake. 4,960 G1 and 4,853 G0 mothers were included in the study population.FINDING...
Source: Vaccine - March 23, 2024 Category: Allergy & Immunology Authors: Jennifer Condie Kate Northstone Daniel Major-Smith Isaac Halstead Source Type: research

Development and validation of VaxConcerns: A taxonomy of vaccine concerns and misinformation with Crowdsource-Viability
We present VaxConcerns, a taxonomy for vaccine concerns and misinformation. VaxConcerns is an easy-to-teach taxonomy of concerns and misinformation commonly found among online anti-vaccination media and is evaluated to produce high-quality data annotations among crowdsource workers, opening the potential adoption of the framework far beyond just academic or medical communities. The taxonomy shows high agreement among experts and outperforms existing taxonomies for vaccine concerns and misinformation when presented to non-expert users. Our proof-of-concept study on the changes in anti-vaccination content during the COVID-19...
Source: Vaccine - March 23, 2024 Category: Allergy & Immunology Authors: Rickard Stureborg Jenna Nichols Bhuwan Dhingra Jun Yang Walter Orenstein Robert A Bednarczyk Lavanya Vasudevan Source Type: research

COVID-19 vaccine reactogenicity among participants enrolled in the GENCOV study
CONCLUSIONS: We provide evidence of relatively mild and short-lived reactions reported by participants who have received approved COVID-19 vaccines.PMID:38521677 | DOI:10.1016/j.vaccine.2024.03.030 (Source: Vaccine)
Source: Vaccine - March 23, 2024 Category: Allergy & Immunology Authors: Gregory Morgan Selina Casalino Sunakshi Chowdhary Erika Frangione Chun Yiu Jordan Fung Elisa Lapadula Saranya Arnoldo Erin Bearss Alexandra Binnie Bjug Borgundvaag Laurent Briollais Marc Dagher Luke Devine Steven M Friedman Zeeshan Khan Chloe Mighton Koni Source Type: research

Evaluation of bird-adapted self-amplifying mRNA vaccine formulations in chickens
In this study, we engineered two Tembusu virus (TMUV; family Flaviviridae) replicons encoding varying capsid gene lengths and compared these to the benchmark VEEV replicon in vitro. The TMUV replicon system exhibited a robust and prolonged transgene expression compared to the VEEV replicon system in both avian and mammalian cells. Moreover, the TMUV replicon induced a lesser cytopathic effect compared to the VEEV replicon RNA in vitro. DNA-launched versions of the TMUV and VEEV replicons (DREP) were also developed. The replicons successfully expressed the AIV haemagglutinin (HA) glycoproteins and the IBDV capsid protein (p...
Source: Vaccine - March 23, 2024 Category: Allergy & Immunology Authors: Jerome D G Comes Kristel Doets Thijmen Zegers Merel Kessler Irene Slits Natalia A Ballesteros Noortje M P van de Weem Henk Pouwels Monique M van Oers Marielle C W van Hulten Martijn Langereis Gorben P Pijlman Source Type: research

Exploring associations between the Big Five personality traits and cognitive ability with COVID-19 vaccination hesitancy and uptake among mothers and offspring in a UK prospective cohort study
This study sought to address these inconsistencies and explore the role of personality and cognitive ability in COVID-19 vaccination hesitancy and uptake in a prospective cohort study.METHODS: Data came from young adults (Generation-1; G1) and their mothers (Generation-0; G0) in the Avon Longitudinal Study of Parents and Children (ALSPAC). Multinomial logistic regressions, adjusting for several sociodemographic confounders, were used to explore whether personality and cognitive ability were associated with COVID-19 vaccination hesitancy and uptake. 4,960 G1 and 4,853 G0 mothers were included in the study population.FINDING...
Source: Vaccine - March 23, 2024 Category: Allergy & Immunology Authors: Jennifer Condie Kate Northstone Daniel Major-Smith Isaac Halstead Source Type: research