A severe interaction between Tizanidine and Ciprofloxacin
Tizanidine is a commonly prescribed medication for muscle spasms [1]. The pharmacokinetics of Tizanidine are altered by the use of CYP1A2 inhibitors as Ciprofloxacin in healthy subjects; elevation of Tizanidine levels leads to a decrease in psychomotor activity and hemodynamic changes which are manifested as a decrease in blood pressure and heart rate [2,3]. (Source: Journal of Clinical Anesthesia)
Source: Journal of Clinical Anesthesia - June 29, 2015 Category: Anesthesiology Authors: Alaa Abd-Elsayed, Hesham Elsharkawy, Wael Sakr Tags: Correspondence Source Type: research
Interventions to Reduce Spasticity and Improve Function in People With Chronic Incomplete Spinal Cord Injury: Distinctions Revealed by Different Analytical Methods
Conclusions. Improvements in function were achieved in a limited number of people with SCI. Using the MID and GMM techniques, differences in responses to interventions between high-and low-functioning participants could be identified. These techniques may, therefore, have potential to be used for characterizing therapeutic effects resulting from different interventions. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - June 25, 2015 Category: Neurology Authors: Duffell, L. D., Brown, G. L., Mirbagheri, M. M. Tags: Clinical Research Articles Source Type: research
A Case of Stiff Person Syndrome: Immunomodulatory Effect of Benzodiazepines: Successful Rituximab and Tizanidine Therapy
This report demonstrates ineffective benzodiazepine therapy of SPS that prompts tachyphylaxis, loss of responsiveness, and finally benzodiazepine withdrawal syndrome. Convulsion and anxiety correlate with high level of creatine phosphokinase (CK). Although tonus and spasm attacks were successfully controlled by tizanidine, glutamate release inhibitor, the immune response, and autoimmune diabetes development require the plasmapheresis, mycophenolat mofetil, and rituximab therapy that results in a significant decrease of GADAb, impaired glucose tolerance (IGT), lactate dehydrogenase (LDH), and CK normalization. Unfortunately...
Source: Medicine - June 1, 2015 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
"Spinal" Movement Disorders in NMO Patients: An Under-Recognized Phenomenon (S46.001)
CONCLUSIONS: Movement disorders are common in NMO patients and can be a major source of disability. Randomized clinical trials are needed to identify effective treatments. Study Supported by:Disclosure: Dr. Abboud has nothing to disclose. Acorda Therapeutics; Sanofi; Viropharma, Inc.; NeuralStem, Inc.; Shire/Abvie; TerumoBCT (Source: Neurology)
Source: Neurology - April 8, 2015 Category: Neurology Authors: Abboud, H., Levy, M. Tags: Neuromyelitis Optica Source Type: research
Scoliosis in Childhood-Onset Stiff Person Syndrome (P2.073)
CONCLUSIONS: In children and young adults with spinal column deformities including hyperlordosis or new scoliosis, the diagnosis of SPS should be considered since early treatment may help reduce long term complications, disability and improve the quality of life. Study Supported by: noneDisclosure: Dr. Rasameesoraj has nothing to disclose. Dr. Katirji has nothing to disclose. Dr. Devereaux has received personal compensation for activities with Digitrace. (Source: Neurology)
Source: Neurology - April 8, 2015 Category: Neurology Authors: Rasameesoraj, T., Katirji, B., Devereaux, M. Tags: Neurological Consequences of Autoimmune Disease Source Type: research
Facilitatory effects of anti-spastic medication on robotic locomotor training in people with chronic incomplete spinal cord injury
The objective of this study was to investigate whether an anti-spasticity medication can facilitate the effects of robotic locomotor treadmill training (LTT) to improve gait function in people with incomplete spinal cord injury (SCI).
Methods:
Individuals with chronic incomplete SCI were recruited and carried out a 4 week intervention of either locomotor treadmill training (LTT) alone (n = 26) or LTT combined with Tizanidine (TizLTT), an anti-spasticity medication (n = 22). Gait function was evaluated using clinical outcome measures of gait, speed and endurance. To better understand the underlying mechanisms of th...
Source: Journal of NeuroEngineering and Rehabilitation - March 20, 2015 Category: Rehabilitation Authors: Lynsey DuffellGeoffrey BrownMehdi Mirbagheri Source Type: research
Drugs used to treat joint and muscle disease
Publication date: Available online 19 February 2015 Source:Anaesthesia & Intensive Care Medicine Author(s): David G. Lambert Joint disease: Arthritis can be simply broken into osteoarthritis and rheumatoid arthritis (RA). Osteoarthritis is treated with symptomatic pain relief and surgery. RA is a chronic autoimmune disease that causes inflammation of joints (leading to their destruction), tissues around joints and other organ systems. Treatment (for pain) of RA in the first instance is with non-steroidal anti-inflammatory drugs, with second-line treatment using disease-modifying antirheumatic drugs (DMARDs). D...
Source: Anaesthesia and intensive care medicine - February 24, 2015 Category: Anesthesiology Source Type: research
Impact of Intravenous Acetaminophen on Reducing Opioid Use After Hysterectomy
ConclusionThe multimodal approach to perioperative analgesic management, which includes concurrent administration of intravenous acetaminophen and opioids, is effective in reducing the total average amount of opioids administered on postoperative days 1–2 and perioperatively. Limitations of this study include its short duration, retrospective design, and single‐site setting. These results may not be generalized to patients undergoing other types of obstetric‐gynecologic surgeries. (Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy)
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - December 17, 2014 Category: Drugs & Pharmacology Authors: Brittany O. Herring, Sheila Ader, Angel Maldonado, Carla Hawkins, Margaretta Kearson, Madeline Camejo Tags: Original Research Article Source Type: research
Cranberry juice ingestion and clinical drug-drug interaction potentials; review of case studies and perspectives.
Authors: Srinivas NR
Abstract
Cranberry juice is a popular beverage with many health benefits. It has anthocyanins to supplement dietary needs. Based on in vitro evidence cranberry juice is an inhibitor of CYP enzymes and at higher amounts as potent as ketoconazole (CYP3A) and fluconazole (CYP2C9). There is, however, a discrepancy between in vitro and in vivo observations with respect to a number of substrates (cyclosporine, warfarin, flurbiprofen, tizanidine, diclofenac, amoxicillin, ceflacor); with the exception of a single report on midazolam, where there was a moderate increase in the AUC of midazolam ...
Source: Journal of Pharmacy and Pharmaceutical Sciences - December 2, 2014 Category: Drugs & Pharmacology Tags: J Pharm Pharm Sci Source Type: research
Patient education and self-care for the management of jaw pain upon awakening: a randomized controlled clinical trial comparing the effectiveness of adding pharmacologic treatment with cyclobenzaprine or tizanidine.
CONCLUSION: The use of tizanidine or cyclobenzaprine in addition to self-care management and patient education was not more effective than placebo for the management of patients with myofascial jaw pain upon awakening.
PMID: 24822235 [PubMed - indexed for MEDLINE] (Source: Journal of Orofacial Pain)
Source: Journal of Orofacial Pain - November 25, 2014 Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research
Profound Symptomatic Bradycardia Requiring Transvenous Pacing After a Single Dose of Tizanidine
We report a case of profound symptomatic bradycardia after a single dose of tizanidine. (Source: The Journal of Emergency Medicine)
Source: The Journal of Emergency Medicine - November 18, 2014 Category: Emergency Medicine Authors: Jennifer Cortes, Brad Hall, Danyelle Redden Tags: Pharmacology in Emergency Medicine Source Type: research
Prescriber perceptions of a near real-time fax alert program for potential drug-drug interactions.
CONCLUSIONS: The positive response to fax alerts by physicians varies by the component drugs of the PDDI alerts.
PMID: 24761821 [PubMed - in process] (Source: Journal of Managed Care Pharmacy)
Source: Journal of Managed Care Pharmacy - November 14, 2014 Category: Drugs & Pharmacology Tags: J Manag Care Pharm Source Type: research
Central noradrenergic mechanisms and the acute stress response during painful stimulation
Events that threaten tissue integrity including noxious stimulation activate central noradrenergic circuits, particularly locus coeruleus and its projections. Recent advances in theory hold that an adaptive, defensive shift in brain activity takes place in response to threat. In principle, this shift may accentuate the autonomic and central biomarkers of the perception of painful events and the experience of pain itself. We have examined the effects of an alpha-2 agonist on pupil dilation responses, skin conductance responses, near field somatosensory evoked potentials and pain reports in normal volunteers undergoing repea...
Source: Journal of Psychopharmacology - November 12, 2014 Category: Psychiatry Authors: Chapman, C. R., Bradshaw, D. H., Donaldson, G. W., Jacobson, R. C., Nakamura, Y. Tags: Original Papers Source Type: research
Hot-melts in Buccoadhesive Patches: An Approach for Bioavailability Enhancement of Highly-Metabolized Drugs with Short Elimination Half-Life.
Abstract
The present study deals with the inclusion or incorporation of hot-melts into buccoadhesive patches. Our aim is to develop a patient-friendly dosage form that is capable of extending release of short elimination half-life drugs so to decrease dosing frequency and to increase the bioavailability of highly-metabolized drugs with the ultimate aim of dose reduction. Tizanidine hydrochloride (TIZ) was used as a model drug. TIZ was incorporated into Compritol-based hot-melts, and then further formulated into buccal patches prepared using HPMC, PVA and Polyox. A Central Composite Face-centered Design was...
Source: European Journal of Pharmaceutics and Biopharmaceutics - October 25, 2014 Category: Drugs & Pharmacology Authors: El Mahrouk GM, El Gazayerly ON, Aboelwafa AA, Taha MS Tags: Eur J Pharm Biopharm Source Type: research
