Drug safety of macrolide and quinolone antibiotics in a tertiary care hospital: administration of interacting co-medication and QT prolongation
Conclusion In the studied real-life setting, we found a considerable number of MQAB users with additional risk factors for TdP but no ECG monitoring. However, adverse drug reactions were rarely found, and costs vs. benefits of ECG monitoring have to be weighted. In contrast, avoidable risk factors and selected contraindicated pharmacokinetic interactions are clear targets for implementation as automated alerts in electronic prescribing systems. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - March 28, 2016 Category: Drugs & Pharmacology Source Type: research

Tizanidine for the management of acute postoperative pain after inguinal hernia repair: A placebo-controlled double-blind trial
BACKGROUND: α2-Agonists are used postoperatively as a component of multimodal analgesia. Tizanidine is a centrally acting α2-agonist with muscle relaxant properties. OBJECTIVE: The aim of this study was to compare the efficacy of tizanidine with placebo in terms of postoperative pain scores, analgesic consumption, return to daily activity and health-related quality of life. DESIGN: A randomised double-blind study. SETTING: Diskapi Yildirim Beyazit Training and Research Hospital. INTERVENTIONS: After obtaining ethical approval and informed patient consent, 60 patients undergoing inguinal hernia repair under general an...
Source: European Journal of Anaesthesiology - February 3, 2016 Category: Anesthesiology Tags: Postoperative pain Source Type: research

Comparison of Efficacy and Side Effects of Oral Baclofen Versus Tizanidine Therapy with Adjuvant Botulinum Toxin Type A in Children With Cerebral Palsy and Spastic Equinus Foot Deformity
This retrospective study aimed to compare the therapeutic response, including side effects, for oral baclofen versus oral tizanidine therapy with adjuvant botulinum toxin type A in a group of 64 pediatric patients diagnosed with static encephalopathy and spastic equinus foot deformity. Following botulinum toxin A treatment, clinical improvement led to the gradual reduction of baclofen or tizanidine dosing to one-third of the former dose. Gross Motor Functional Measure and Caregiver Health Questionnaire scores were markedly elevated post–botulinum toxin A treatment, with scores for the tizanidine (Gross Motor Function...
Source: Journal of Child Neurology - January 12, 2016 Category: Neurology Authors: Dai, A. I., Aksoy, S. N., Demiryürek, A. T. Tags: Original Articles Source Type: research

Long-term myocardial toxicity in a patient with tizanidine and etizolam overdose
Publication date: Available online 28 November 2015 Source:Journal of Cardiology Cases Author(s): Mari Amino, Koichiro Yoshioka, Yuji Ikari, Sadaki Inokuchi Tizanidine hydrochloride, α2-receptor stimulant, is a central muscle relaxant. Etizolam is a benzodiazepine-based anti-anxiety agent. Both drugs are widely used for the treatment of a variety of muscle pain and frequently used together in Japan. We experienced a case of complicating prolonged myocardial dysfunction in a 56-year-old woman. Six hours after overdose of 48mg tizanidine and 24mg etizolam, she showed sinus bradycardia and peripheral vascular res...
Source: Journal of Cardiology Cases - January 12, 2016 Category: Cardiology Source Type: research

Tizanidine-induced acute severe cystitis in a female taking famotidine.
We report a case of a 26-year-old Asian female on famotidine who presented with acute severe urinary burning after taking tizanidine. PMID: 26251632 [PubMed] (Source: Clinical Pharmacology: Advances and Applications)
Source: Clinical Pharmacology: Advances and Applications - November 29, 2015 Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research

Analgesic efficacy of oral gabapentin added to standard epidural corticosteroids in patients with failed back surgery.
CONCLUSION: It was concluded that addition of oral gabapentin to epidural corticosteroid application in patients with failed back surgery syndromes was effective in ameliorating pain at an early stage without significant side effects. PMID: 22291506 [PubMed] (Source: Clinical Pharmacology: Advances and Applications)
Source: Clinical Pharmacology: Advances and Applications - November 29, 2015 Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research

Tizanidine and Speech Therapy for Spastic Dysarthria: A Case Study
To evaluate tizanidine with speech therapy for dysarthria associated with spastic tetraplegia. (Source: Archives of Physical Medicine and Rehabilitation)
Source: Archives of Physical Medicine and Rehabilitation - November 23, 2015 Category: Rehabilitation Authors: Jon A. Mukand, Patricia Swift Fulton, Minh Tran, Nita H. Mukand Tags: Research Poster Source Type: research

Spinal antinociceptive action of amiloride and its interaction with tizanidine in the rat formalin test.
PMID: 26357686 [PubMed - as supplied by publisher] (Source: Pain Research and Management)
Source: Pain Research and Management - September 10, 2015 Category: Anesthesiology Authors: Ouyang H, Wang P, Huang W, Li Q, Nie B, Zeng W Tags: Pain Res Manag Source Type: research

Evaluation of tizanidine as a marker of canine CYP1A2 activity
The dog CYP1A2 enzyme is likely an important contributor to the metabolism of veterinary drugs. Dog CYP1A2 is expressed in liver, plus it is inducible and polymorphic, creating the potential for intersubject differences in pharmacokinetics. Hence, the ability to probe dog CYP1A2 activity and inhibition is relevant toward veterinary drug development and drug–drug interaction assessment. Previous studies have relied on human probes with questionable specificity for CYP1A2, so it was hypothesized that recombinant CYP1A2 could be used to find a specific CYP1A2 substrate. Intrinsic clearance experiments demonstrated that tiza...
Source: Journal of Veterinary Pharmacology and Therapeutics - July 30, 2015 Category: Veterinary Research Authors: C. W. Locuson, P. Williams, J. M. Adcock, J. S. Daniels Tags: Scientific Paper Source Type: research

Tizanidine-induced acute severe cystitis in a female taking famotidine
We report a case of a 26-year-old Asian female on famotidine who presented with acute severe urinary burning after taking tizanidine. Keywords: adverse drug reaction, cystitis, famotidine, tizanidine (Source: International Journal of COPD)
Source: International Journal of COPD - July 29, 2015 Category: Respiratory Medicine Tags: Clinical Pharmacology: Advances and Applications Source Type: research

Tizanidine-induced cystitis
Poudel RR, Kafle NK (Source: International Journal of COPD)
Source: International Journal of COPD - July 28, 2015 Category: Respiratory Medicine Source Type: research

A severe interaction between Tizanidine and Ciprofloxacin
Tizanidine is a commonly prescribed medication for muscle spasms [1]. The pharmacokinetics of Tizanidine are altered by the use of CYP1A2 inhibitors as Ciprofloxacin in healthy subjects; elevation of Tizanidine levels leads to a decrease in psychomotor activity and hemodynamic changes which are manifested as a decrease in blood pressure and heart rate [2,3]. (Source: Journal of Clinical Anesthesia)
Source: Journal of Clinical Anesthesia - June 29, 2015 Category: Anesthesiology Authors: Alaa Abd-Elsayed, Hesham Elsharkawy, Wael Sakr Tags: Correspondence Source Type: research

Interventions to Reduce Spasticity and Improve Function in People With Chronic Incomplete Spinal Cord Injury: Distinctions Revealed by Different Analytical Methods
Conclusions. Improvements in function were achieved in a limited number of people with SCI. Using the MID and GMM techniques, differences in responses to interventions between high-and low-functioning participants could be identified. These techniques may, therefore, have potential to be used for characterizing therapeutic effects resulting from different interventions. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - June 25, 2015 Category: Neurology Authors: Duffell, L. D., Brown, G. L., Mirbagheri, M. M. Tags: Clinical Research Articles Source Type: research

A Case of Stiff Person Syndrome: Immunomodulatory Effect of Benzodiazepines: Successful Rituximab and Tizanidine Therapy
This report demonstrates ineffective benzodiazepine therapy of SPS that prompts tachyphylaxis, loss of responsiveness, and finally benzodiazepine withdrawal syndrome. Convulsion and anxiety correlate with high level of creatine phosphokinase (CK). Although tonus and spasm attacks were successfully controlled by tizanidine, glutamate release inhibitor, the immune response, and autoimmune diabetes development require the plasmapheresis, mycophenolat mofetil, and rituximab therapy that results in a significant decrease of GADAb, impaired glucose tolerance (IGT), lactate dehydrogenase (LDH), and CK normalization. Unfortunately...
Source: Medicine - June 1, 2015 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research