Analysis of Drug-Drug Interactions in Swiss Claims Data Using Tizanidine and Ciprofloxacin as a Prototypical Contraindicated Combination.
Conclusion and Relevance: The interaction between tizanidine and ciprofloxacin is not only relevant for individual patients, but also at the population level. Further investigation of the impact of other clinically relevant DDIs is necessary to improve patient safety and reduce avoidable health care utilization.
PMID: 29749261 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - May 1, 2018 Category: Drugs & Pharmacology Authors: Jödicke AM, Curkovic I, Zellweger U, Tomka IT, Neuer T, Kullak-Ublick GA, Roos M, Egbring M Tags: Ann Pharmacother Source Type: research
Inhibition of In Vitro Metabolism of Opioids by Skeletal Muscle Relaxants
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 5, 2018 Category: Drugs & Pharmacology Authors: David E. Moody, Yueqiao Fu, Wenfang B. Fang Tags: Original Article Source Type: research
Surface modification and evaluation of bacterial cellulose for drug delivery.
Abstract
The current study was designed to prepare surface modified BC matrices loaded with model drugs selected on the basis of their aqueous solubility, i.e., poorly water soluble famotidine and highly water soluble tizanidine. Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA) confirmed the successful drug loading and thermal stability of the BC matrices. In-vitro dissolution studies using USP type-II dissolution apparatus showed that most of the drug was released in 0.5-3 h from famotidine loaded matrices a...
Source: International Journal of Biological Macromolecules - February 22, 2018 Category: Biochemistry Authors: Badshah M, Ullah H, Khan AR, Khan S, Park JK, Khan T Tags: Int J Biol Macromol Source Type: research
Ultrasound-guided bilateral superficial cervical block and preemptive single-dose oral tizanidine for post-thyroidectomy pain: a randomized-controlled double-blind study
ConclusionsUltrasound-guided BSCPB with or without preemptive oral tizanidine was effective at reducing postoperative pain and opioid consumption in patients undergoing total thyroidectomy. Addition of preemptive oral tizanidine to BSCPB reduced the early postoperative opioid consumption, posterior neck pain, and occipital headache.Clinical trials registryThe study was registered with a clinical trials registry (ClinicalTrials.gov. identifier NCT02725359). (Source: Journal of Anesthesia)
Source: Journal of Anesthesia - February 21, 2018 Category: Anesthesiology Source Type: research
Variable impact of tizanidine on the medium latency reflex of upper and lower limbs.
We examined whether group II afferents contribute to MLR activity throughout the major muscles that span the elbow and shoulder. MLRs of ankle muscles were also tested during walking on the same day, in the same participants as well as during sitting in a different group of subjects. In contrast to previous reports, the ingestion of tizanidine had minimal impact on MLRs of arm or leg muscles during motor actions. A significant decrease in magnitude was observed for 2/16 contrasts in arm muscles and 0/4 contrasts in leg muscles. This discrepancy with previous studies could indicate that tizanidine's efficacy is altered by s...
Source: Experimental Brain Research - January 3, 2018 Category: Neuroscience Authors: Kurtzer I, Bouyer LJ, Bouffard J, Jin A, Christiansen L, Nielsen JB, Scott SH Tags: Exp Brain Res Source Type: research
Importance of Medication Reconciliation: Tizanidine-Induced Hepatitis
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2017 Category: Drugs & Pharmacology Tags: Letters to the Editors Source Type: research
Non ‐medical use of psychoactive prescription drugs is associated with fatal poisoning
ConclusionsNon‐prescribed psychoactive drugs are commonly found at post‐mortem in drug poisoning deaths in Finland with history of drug abuse being a major contributing factor. (Source: Addiction)
Source: Addiction - August 26, 2017 Category: Addiction Authors: Jari Haukka, Pirkko Kriikku, Claudia Mariottini, Timo Partonen, Ilkka Ojanper ä Tags: Research Report Source Type: research
A novel non-opioid protocol for medically supervised opioid withdrawal and transition to antagonist treatment.
CONCLUSION: This retrospective chart review suggests the feasibility of a novel protocol for medically supervised opioid withdrawal and transition to relapse prevention strategies, including injectable ER naltrexone. This withdrawal protocol does not utilize opioid agonists or other controlled substances..
PMID: 28795846 [PubMed - as supplied by publisher] (Source: The American Journal of Drug and Alcohol Abuse)
Source: The American Journal of Drug and Alcohol Abuse - August 10, 2017 Category: Addiction Authors: Rudolf G, Walsh J, Plawman A, Gianutsos P, Alto W, Mancl L, Rudolf V Tags: Am J Drug Alcohol Abuse Source Type: research
Melanin binding study of clinical drugs with cassette dosing and rapid equilibrium dialysis inserts.
In this study, we introduce a powerful tool for screening of melanin binding. The binding of a set of 34 compounds to isolated porcine RPE melanin was determined by cassette (n-in-one) dosing in rapid equilibrium dialysis inserts and the binding was quantitated with LC-MS/MS analytics. The compounds represented large variety in melanin binding (from 8.6%, ganciclovir) to over 95% bound (ampicillin and ciprofloxacin). The data provides information on melanin binding of small molecular weight compounds that are used for ocular (e.g. brinzolamide, ganciclovir) and systemic (e.g. tizanidine, indomethacin) therapy. Interestingl...
Source: European Journal of Pharmaceutical Sciences - July 26, 2017 Category: Drugs & Pharmacology Authors: Pelkonen L, Tengvall-Unadike U, Ruponen M, Kidron H, Del Amo EM, Reinisalo M, Urtti A Tags: Eur J Pharm Sci Source Type: research
Hemopericardium under dabigatran for stroke prevention in atrial fibrillation
We report a polymorbid 75-year old male under a therapy with dabigatran, valsartan, amlodipine, nicorandil, furosemide, atorvastatin, bisoprolol, metformin, tizanidine, pantoprazole, and tramadol. He suffered from chest pain for 4 months. Coronary angiography showed only ectatic coronary arteries. He started taking nonsteroidal anti-inflammatory drugs. He was hospitalized because of dyspnea starting 10 days before admission, melena, and renal failure. Hemopericardium was diagnosed and pericardiocentesis yielded 2000 ml hemorrhagic fluid. Review of previous echocardiograms showed a 4 mm echo-free space, epicardial fat o...
Source: Blood Coagulation and Fibrinolysis - February 11, 2017 Category: Hematology Tags: Case Reports Source Type: research
Nanotransfersomes-loaded thermosensitive in situ gel as a rectal delivery system of tizanidine HCl: preparation, in vitro and in vivo performance.
Authors: Moawad FA, Ali AA, Salem HF
Abstract
The purpose of the current study was to develop tizanidine HCl (TIZ; a myotonolytic agent used for treatment of spasticity) loaded nanotransfersomes intended for rectal administration, aiming to bypass the hepatic first-pass metabolism. TIZ-loaded nanotransfersomes were prepared by thin-film hydration method followed by characterization for various parameters including entrapment efficiency, vesicle diameter, in vitro release and ex vivo permeation studies. Transfersomal formulation composed of phosphatidylcholine and Tween 80 at a weight ratio of (85:15) gave ...
Source: Drug Delivery - February 6, 2017 Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
Potential drug-drug interactions in the pediatric intensive care unit of a pulmonary teaching hospital
Conclusions: Life-threatening drug interactions may develop in pediatric patients hospitalized in the PICU. Clinical managements such as avoiding combination, close monitoring, and considering related risk factors could prevent the consequences of these interactions. (Source: European Respiratory Journal)
Source: European Respiratory Journal - November 7, 2016 Category: Respiratory Medicine Authors: Baniasadi, S., Hassanzad, M., Alehashem, M. Tags: 7.5 Neonatology and Paediatric Intensive Care Source Type: research
Pharmacological management of spasticity in multiple sclerosis: Systematic review and consensus paper
Conclusion:
The available studies on spasticity treatment offer some insight to guide clinical practice but are of variable methodological quality. Large, well-designed trials are needed to confirm the effectiveness of antispasticity agents and to produce evidence-based treatment algorithms. (Source: Multiple Sclerosis)
Source: Multiple Sclerosis - October 2, 2016 Category: Neurology Authors: Otero-Romero, S., Sastre-Garriga, J., Comi, G., Hartung, H.-P., Soelberg Sorensen, P., Thompson, A. J., Vermersch, P., Gold, R., Montalban, X. Tags: Review Source Type: research
Poster 257 Tizanidine Reduces Night Sweats due to Dysautonomia in Syringomyelia: A Case Report
Ryan Menard: I Have No Relevant Financial Relationships To Disclose (Source: PM and R)
Source: PM and R - August 31, 2016 Category: Rehabilitation Authors: Ryan A. Menard, Daniel Moon, Paul Hurd Source Type: research
Clinical efficacy and safety of eperisone for low back pain: A systematic literature review.
Abstract
Eperisone, an analgesic and centrally acting muscle relaxant has been in use for the treatment of low back pain (LBP). The present systematic review evaluates the efficacy and safety of eperisone in patients with LBP. Cochrane Back and Neck (CBN) Group and Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were adopted to perform this systematic review. For risk of bias assessment CBN Group and Moga tools were used. Seven (5 randomized controlled trials [RCTs] and 2 uncontrolled studies) studies involving 801 participants were included. Eperisone intervention ma...
Source: Pharmacological Reports - June 28, 2016 Category: Drugs & Pharmacology Authors: Bavage S, Durg S, Ali Kareem S, Dhadde SB Tags: Pharmacol Rep Source Type: research
