Daclizumab/tizanidine
(Source: Reactions Weekly)
Source: Reactions Weekly - May 31, 2019 Category: Drugs & Pharmacology Source Type: research
A Randomized, Placebo-Controlled Trial of Ibuprofen Plus Metaxalone, Tizanidine, or Baclofen for Acute Low Back Pain
ConclusionAdding baclofen, metaxalone, or tizanidine to ibuprofen does not appear to improve functioning or pain any more than placebo plus ibuprofen by 1 week after an ED visit for acute low back pain. (Source: Annals of Emergency Medicine)
Source: Annals of Emergency Medicine - April 6, 2019 Category: Emergency Medicine Source Type: research
Comparison the Effects of Oral Tizanidine and Tramadol on Intra- and Post-operative Shivering in Patients Underwent Spinal Anesthesia.
Conclusions: Oral TI and tramadol were comparable in respect to their effect in decreasing the incidence, intensity shivering when used prophylactically in patients who underwent TURP with spinal anesthesia.
PMID: 30505811 [PubMed] (Source: Biomed Res)
Source: Biomed Res - December 8, 2018 Category: Research Authors: Adinehmehr L, Salimi S, Majedi MA, Alizadeh A, Sane S Tags: Adv Biomed Res Source Type: research
A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis.
Authors: Arroyo González R
Abstract
INTRODUCTION: Multiple sclerosis (MS) is a complex disease with a heterogeneous and unpredictable clinical course. Mobility impairment after progressive paralyses and muscle tone spasticity is common. Areas covered: The prevalence, assessment, and pharmacological management of gait impairment and spasticity in MS and their effects on health-related quality of life (HRQoL) are discussed. The roles of oral and intrathecal baclofen and of delta-9-tetrahydrocannabinol/cannabidiol (THC:CBD) oromucosal spray in treating MS spasticity-related gait impairment are reviewed. Expert comme...
Source: Expert Review of Neurotherapeutics - September 22, 2018 Category: Neurology Tags: Expert Rev Neurother Source Type: research
Co-prescription of Strong CYP1A2 Inhibitors and the Risk of Tizanidine-Associated Hypotension: A Retrospective Cohort Study.
In conclusion, CYP1A2 inhibition increases the risk of hypotensive episodes associated with the use of tizanidine in routine clinical practice. This article is protected by copyright. All rights reserved.
PMID: 30223305 [PubMed - as supplied by publisher] (Source: Clinical Pharmacology and Therapeutics)
Source: Clinical Pharmacology and Therapeutics - September 17, 2018 Category: Drugs & Pharmacology Authors: Chaugai S, Dickson AL, Shuey MM, Feng Q, Barker KA, Wei WQ, Luther JM, Stein CM, Chung CP Tags: Clin Pharmacol Ther Source Type: research
Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF- κB pathway.
Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway.
Int J Mol Med. 2018 Sep 13;:
Authors: Pei W, Zou Y, Wang W, Wei L, Zhao Y, Li L
Abstract
Recently, α2-adrenoceptors (α2-AR) agonists have been shown to have anti-nociceptive effects and thus may become a promising therapeutic strategy for neuropathic pain. tizanidine is a highly selective α2-AR agonist, but the effect mechanism of tizanidine in neuropathic pain remains largely unknown. The present study investigated whether tizanidine has anti-n...
Source: International Journal of Molecular Medicine - September 13, 2018 Category: Molecular Biology Authors: Pei W, Zou Y, Wang W, Wei L, Zhao Y, Li L Tags: Int J Mol Med Source Type: research
Fabrication and Characterization of Matrix Type Transdermal Patches Loaded With Tizanidine Hydrochloride: Potential Sustained Release Delivery System.
CONCLUSION: The results demonstrated that topically applied transdermal patch will be a potential medicated sustain release patch for muscle pain which will improve patient compliance.
PMID: 30081679 [PubMed - as supplied by publisher] (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - August 8, 2018 Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Rectal administration of baclofen at the end of life
Spasticity can be a complicating symptom of a variety of neurological conditions such as multiple sclerosis, motor neuron disease, Creutzfeldt-Jakob disease, or post-stroke. Several pharmacological treatment options are available, including baclofen, tizanidine, gabapentin, botulinum toxin A and tetrahydrocannabinol/canabidiol (1, 2). However, treatment feasibility decreases as the end of life approaches, e.g. when patients are no longer able to tolerate oral medications, the onset of action would be too long, or the initiation of parenteral drug therapy (intravenous, intrathecal) is no longer indicated or appropriate. (So...
Source: Journal of Pain and Symptom Management - August 7, 2018 Category: Palliative Care Authors: Charlotte Selge, Claudia Bausewein, Constanze Remi Source Type: research
Investigation of the electrochemical behavior of tizanidine on the surface of glassy carbon electrode modified with multi-walled carbon nanotube/titan yellow–doped polypyrrole
Publication date: 15 August 2018Source: Journal of Electroanalytical Chemistry, Volume 823Author(s): Saeed Shahrokhian, Maryam Shamloofard, Razieh SalimianAbstractThe present paper describes a voltammetric sensor based on glassy carbon electrode (GCE) modified with a thin film of multi-walled carbon nanotubes (MWCNTs) coated with an electro-polymerized layer of titan yellow-doped over–oxidized polypyrrole (OPPY) for the determination of tizanidine (TIZ). A significant enhancement was observed in the anodic peak current of TIZ on the surface of OPPY/CNT/GCE, relative to the bare, CNT- and OPPY-coated GCEs. The microscopic...
Source: Journal of Electroanalytical Chemistry - July 11, 2018 Category: Chemistry Source Type: research
Investigation of the electrochemical behavior of tizanidine on the surface of glassy carbon electrode modified with multi-walled carbon nanotube/titan yellow –doped polypyrrole
Publication date: 15 August 2018 Source:Journal of Electroanalytical Chemistry, Volume 823 Author(s): Saeed Shahrokhian, Maryam Shamloofard, Razieh Salimian The present paper describes a voltammetric sensor based on glassy carbon electrode (GCE) modified with a thin film of multi-walled carbon nanotubes (MWCNTs) coated with an electro-polymerized layer of titan yellow-doped over–oxidized polypyrrole (OPPY) for the determination of tizanidine (TIZ). A significant enhancement was observed in the anodic peak current of TIZ on the surface of OPPY/CNT/GCE, relative to the bare, CNT- and OPPY-coated GCEs. The microscopic ...
Source: Journal of Electroanalytical Chemistry - June 19, 2018 Category: Chemistry Source Type: research
A comparative study of sterically and electro-statically stabilized silver nanoparticles for the determination of muscle relaxant tizanidine: Insights of localized surface plasmon resonance, surface enhanced Raman spectroscopy and electrocatalytic activity.
Abstract
A comparative study of two types of silver nanoparticles was investigated. The effect of the surface chemistry of the studied silver nanoparticles (AgNPs) on their localized surface plasmon resonance was utilized for the quantitative determination of muscle relaxant tizanidine drug. The studied AgNPs are classified according to the type of stabilizing agent used in their synthesis into electrostatically and sterically stabilized AgNPs. The electrostatically-stabilized AgNPs (AA AgNPs) were prepared using ascorbic acid as both reducing and protective agents in alkaline medium. The sterically-stabil...
Source: Talanta - May 24, 2018 Category: Chemistry Authors: El-Zahry MR Tags: Talanta Source Type: research
Tizanidine is not effective in treating EPMS
Extrapyramidal motoric symptoms (EPMS) are common adverse side effects of conventional antipsychotics (Greil et al., 2013), which can be reduced by Biperiden, an anticholinergic acting drug. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 19, 2018 Category: Biomedical Science Authors: Helmut Niederhofer Source Type: research
Tizanidine is not effective treating EPMS
Extrapyramidal motoric symptoms (EPMS) are common adverse side effects of conventional antipsychotics [1], which can be reduced by Biperiden, an anticholinergic acting drug. (Source: Medical Hypotheses)
Source: Medical Hypotheses - May 19, 2018 Category: Biomedical Science Authors: Helmut Niederhofer Source Type: research
Clinically Significant Bradycardia From Tizanidine
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - May 1, 2018 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research
