Coadministration of tizanidine and ciprofloxacin: a retrospective analysis of the WHO pharmacovigilance database
ConclusionDespite the existing formal contraindication, the concomitant use of tizanidine and ciprofloxacin can be observed in real-world clinical practice. Reactions mainly affected the central nervous and the cardiovascular system resulting in potentially severe adverse effects. The concomitant use of tizanidine and ciprofloxacin should absolutely be avoided. (Source: European Journal of Clinical Pharmacology)
Source: European Journal of Clinical Pharmacology - January 6, 2021 Category: Drugs & Pharmacology Source Type: research
High dose naloxone for acute tizanidine overdose in the emergency department: a case report
. (Source: Clinical Toxicology)
Source: Clinical Toxicology - January 6, 2021 Category: Toxicology Authors: Amber Adams Colton Copley Source Type: research
Molecules, Vol. 25, Pages 4930: A Critical Review of the Role of the Cannabinoid Compounds Δ9-Tetrahydrocannabinol (Δ9-THC) and Cannabidiol (CBD) and their Combination in Multiple Sclerosis Treatment
hou
Many people with MS (pwMS) use unregulated cannabis or cannabis products to treat the symptoms associated with the disease. In line with this, Sativex, a synthetic combination of cannabidiol (CBD) and Δ9-tetrahydrocannabinol (Δ9-THC) has been approved to treat symptoms of spasticity. In animals, CBD is effective in reducing the amounts of T-cell infiltrates in the spinal cord, suggesting CBD has anti-inflammatory properties. By doing this, CBD has shown to delay symptom onset in animal models of multiple sclerosis and slow disease progression. Importantly, combinations of CBD and &am...
Source: Molecules - October 25, 2020 Category: Chemistry Authors: Éamon Jones Styliani Vlachou Tags: Review Source Type: research
Molecules, Vol. 25, Pages 4109: Development and Validation of an HPLC-UV Detection Assay for the Determination of Clonidine in Mouse Plasma and Its Application to a Pharmacokinetic Study
Mostafa
An accurate and simple HPLC-UV method has been developed for the determination of clonidine in mouse plasma. A reversed phase C18 Nova Pack® column (125 mm × 4.6 mm i.d., × 3 μm particle size) was used as stationary phase. The mobile phase composition was a mixture of 0.1% diethylamine/acetonitrile (70:30, v/v) at pH 8 in an isocratic mode at flow rate was 1.0 mL/min. Detection was set at 210 nm. Tizanidine was used as an internal standard. The clonidine and tizanidine were extracted from plasma matrix using the deproteinization technique. The developed method ...
Source: Molecules - September 7, 2020 Category: Chemistry Authors: Haitham AlRabiah Sabry M. Attia Nasser S. Al-Shakliah Gamal A. E. Mostafa Tags: Article Source Type: research
Development and Stability Control of Pediatric Oral Tizanidine Hydrochloride Formulations for Hospital Use.
This study aim was to develop and improve tizanidine hydrochloride liquid formulations from raw material and to evaluate their stability. A stability-indicating high performance liquid chromatography method was validated for two formulations developed. Fifteen formulations were developed containing syrup and fifteen containing sodium carboxymethyl cellulose as vehicles, to select the two most suitable for stability testing. The formulations were prepared in triplicate and placed in amber polyethylene terephthalate and glass bottles, which were stored under three different conditions: at room temperature (15-30°C), under r...
Source: AAPS PharmSciTech - July 28, 2020 Category: Drugs & Pharmacology Authors: Gobetti C, Balsan ME, Ayres MV, de Almeida SHO, de Saldanha Simon E, Wingert NR, Oppe TP, Garcia CV Tags: AAPS PharmSciTech Source Type: research
Development of Solid Self-Microemulsifying System of Tizanidine Hydrochloride for Oral Bioavailability Enhancement: In Vitro and In Vivo Evaluation.
Abstract
The aim of the present investigation was to formulate self-microemulsifying drug delivery system (SMEDDS) tablets to enhance the oral bioavailability of tizanidine hydrochloride. SMEDDS was prepared by using Capmul G as the oil phase, Tween 20 as the surfactant, and propylene glycol as the co-surfactant. The optimized formulation was characterized by dilution test, % transmittance, thermodynamic stability, dye solubility, assay, globule size, zeta potential, and TEM. A dye solubility test confirmed the formation of o/w microemulsion. Optimized formulation of SMEDDS had a drug content of 98 ± ...
Source: AAPS PharmSciTech - June 30, 2020 Category: Drugs & Pharmacology Authors: Pramanik S, Thakkar H Tags: AAPS PharmSciTech Source Type: research
[ASAP] Thermoreversible Switchlike Electrocatalytic Reduction of Tizanidine Based on a Graphene Oxide Tethered Stimuli-Responsive Smart Surface Supported Pd Catalyst
Analytical ChemistryDOI: 10.1021/acs.analchem.0c00958 (Source: Analytical Chemistry)
Source: Analytical Chemistry - June 18, 2020 Category: Chemistry Authors: Bhuvanenthiran Mutharani †, Palraj Ranganathan‡, Tse-Wei Chen§, Shen-Ming Chen*†, and Jeyaraj vinoth kumar? Source Type: research
Optimization of Microemulgel for Tizanidine Hydrochloride
(Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry)
Source: Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry - June 13, 2020 Category: Allergy & Immunology Authors: Jagdale, Swati Brahmane, Sujata Chabukswar, Anuruddha Tags: Research article Source Type: research
Effect of Vemurafenib on the Pharmacokinetics of a Single Dose of Tizanidine (a CYP1A2 Substrate) in Patients With BRAFV600 Mutation –Positive Malignancies
This study confirmed vemurafenib as a moderate inhibitor of CYP1A2 in vivo, with a statistically significant drug‐drug inte raction with tizanidine. Caution should be exercised when dosing vemurafenib concurrently with CYP1A2 substrates. (Source: Clinical Pharmacology in Drug Development)
Source: Clinical Pharmacology in Drug Development - April 19, 2020 Category: Drugs & Pharmacology Authors: Weijiang Zhang,
Christine McIntyre,
Todd Riehl,
Harper Forbes,
Enric Bertran,
Hye Jin Choi,
Dae Ho Lee,
Jeeyun Lee Tags: Original Manuscript Source Type: research
Incidence of muscle relaxant use in relation to diagnosis of Parkinson ’s disease
Conclusions The incidence of muscle relaxant use starts increasing years before the diagnosis of Parkinson ’s disease but declines after that. It is important to identify the causes of muscle symptoms to avoid unnecessary muscle relaxant use and consequent adverse effects and events. (Source: International Journal of Clinical Pharmacy)
Source: International Journal of Clinical Pharmacy - March 5, 2020 Category: Drugs & Pharmacology Source Type: research
Tizanidine (Hydrochloride) Inhibits A549 Lung Cancer Cell Proliferation and Motility Through Regulating Nischarin
(Source: OncoTargets and Therapy)
Source: OncoTargets and Therapy - January 9, 2020 Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Neurogenic orthostatic hypotension induced by tizanidine
(Source: Clinical Autonomic Research)
Source: Clinical Autonomic Research - September 17, 2019 Category: Research Source Type: research
Consensus of the Brazilian Headache Society on the treatment of chronic migraine
ABSTRACT Chronic migraine poses a significant personal, social and economic burden and is characterized by headache present on 15 or more days per month for at least three months, with at least eight days of migrainous headache per month. It is frequently associated with analgesic or acute migraine medication overuse and this should not be overlooked. The present consensus was elaborated upon by a group of members of the Brazilian Headache Society in order to describe current evidence and to provide recommendations related to chronic migraine pharmacological and nonpharmacological treatment. Withdrawal strategies in medica...
Source: Arquivos de Neuro-Psiquiatria - July 29, 2019 Category: Neurology Source Type: research
Tizanidine hydrochloride exhibits a cytotoxic effect on osteosarcoma cells through the PI3K/AKT signaling pathway.
CONCLUSIONS: THC may play a novel role in OS cell cytotoxicity, and these findings suggest a potent therapeutic strategy for OS treatment.
PMID: 31179788 [PubMed - as supplied by publisher] (Source: Cell Research)
Source: Cell Research - June 9, 2019 Category: Cytology Authors: Xing XW, Sun YF, Zhao J, Pan ZX, Jiang WX Tags: J Int Med Res Source Type: research
