Journal club
This study was undertaken at 11 hospitals in the UK and one in Australia. 142 patients were randomised 1:1 to the IPC or chest drain. The primary outcome... (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Iqbal, B. Tags: Thorax Journal club Source Type: research
Development of respiratory care guidelines for Duchenne muscular dystrophy in the UK: key recommendations for clinical practice
Conclusions
These guidelines provide practical, reasoned recommendations for all those managing day-to-day and acute respiratory care in children and adults with DMD. The hope is that this will support patients and healthcare professionals in accessing high standards of care across the UK. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Childs, A.-M., Turner, C., Astin, R., Bianchi, S., Bourke, J., Cunningham, V., Edel, L., Edwards, C., Farrant, P., Heraghty, J., James, M., Massey, C., Messer, B., Michel Sodhi, J., Murphy, P. B., Schiava, M., Thomas, A., Trucco, F., Guglieri, M. Tags: Open access, Thorax State of the art review Source Type: research
Improved pulmonary function and exercise tolerance despite persistent pulmonary fibrosis over 1 year after severe COVID-19 infection
We conducted a prospective single-centre cohort study of 104 multi-ethnic severe COVID-19 survivors from the first wave of the pandemic 15 months after hospitalisation. Of those who were assessed at 4 and 15 months, improvement of ground glass opacities correlated with worsened fibrotic reticulations. Despite a high prevalence of fibrotic patterns (64%), pulmonary function, grip strength, 6 min walk distance and frailty normalised. Overall, dyspnoea, cough and exhaustion did not improve and were not correlated with pulmonary function or radiographic fibrosis at 15 months, suggesting non-respiratory aetiologies. Monitoring ...
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: McGroder, C. F., Salvatore, M. M., D'Souza, B. M., Hoffman, E. A., Baldwin, M. R., Garcia, C. K. Tags: Thorax, COVID-19 Short report Source Type: research
Serum cytokine biosignatures for identification of tuberculosis among HIV-positive inpatients
Conclusions
The four-cytokine biosignature model successfully identified TB among HIV-positive inpatients. This diagnostic model may be an alternative approach to diagnose TB in advanced HIV-positive inpatients with low CD4+ T-cell counts. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Zhang, H., Li, L., Liu, Y., Xiao, W., Xu, R., Lu, M., Hao, W., Gao, Y., Tang, X., Dai, Y. Tags: Open access, Thorax Tuberculosis Source Type: research
Impact of post-COVID-19 condition on health status and activities of daily living: the PRIME post-COVID study
Conclusions
Individuals with PCC have substantially worse health and more ADL impairment than negative controls, irrespective of the case definition. Authorities should inform the public about the associated burden of PCC and enable adequate support. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Van Herck, M., Pagen, D. M. E., van Bilsen, C. J. A., Brinkhues, S., Konings, K., den Heijer, C. D. J., Mujakovic, S., ter Waarbeek, H. L. G., Burtin, C., Janssen, D. J. A., Hoebe, C. J. P. A., Spruit, M. A., Dukers-Muijrers, N. H. T. M. Tags: Thorax, COVID-19 Respiratory infection Source Type: research
Body composition and respiratory outcomes in children: a population-based prospective cohort study
Conclusion
Adolescents with higher total and abdominal fat indices may have impaired lung function, while those with a higher lean mass during childhood and adolescence may have better small airway function. Public health measures should focus on a healthy body composition in adolescents to minimise respiratory morbidity. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Wu, T., Santos, S., Quezada-Pinedo, H. G., Vernooij, M. W., Jaddoe, V. W. V., Klein, S., Duijts, L., Oei, E. H. G. Tags: Thorax Respiratory epidemiology Source Type: research
Do pulmonary rehabilitation programmes improve outcomes in patients with COPD posthospital discharge for exacerbation: a systematic review and meta-analysis
Discussion
Pulmonary rehabilitation delivered posthospital discharge for exacerbation of COPD results in a reduction in hospital re-admissions and improvements in exercise capacity, health-related quality of life and dyspnoea in the absence of any intervention-related adverse events.
Trial registration number
CRD42023406397. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Jenkins, A. R., Burtin, C., Camp, P. G., Lindenauer, P., Carlin, B., Alison, J. A., Rochester, C., Holland, A. E. Tags: Thorax Rehabilitation Source Type: research
Prognostic factors for survival in unresectable stage III EGFR mutation-positive lung adenocarcinoma: impact of pre-CCRT PET-CT
Conclusion
Pre-CCRT staging with PET-CT in patients with unresectable EGFR mutation-positive adenocarcinoma of clinical stage IIIA–IIIC was associated with enhanced survival. Independent prognostic factors were also identified. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Lin, W.-C., Chen, W.-M., Shia, B.-C., Wu, S.-Y. Tags: Thorax Lung cancer Source Type: research
Mild elevation of pulmonary vascular resistance predicts mortality regardless of mean pulmonary artery pressure in mild interstitial lung disease
Conclusions
Mild elevation of PVR was associated with a higher mortality rate in patients with newly diagnosed ILD, even in those with MPAP≤20 mm Hg. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Sato, T., Furukawa, T., Teramachi, R., Fukihara, J., Yamano, Y., Yokoyama, T., Matsuda, T., Kataoka, K., Kimura, T., Sakamoto, K., Ishii, M., Kondoh, Y. Tags: Editor's choice, Thorax Interstitial lung disease Source Type: research
Greenhouse gas emissions associated with suboptimal asthma care in the UK: the SABINA healthCARe-Based envirONmental cost of treatment (CARBON) study
Conclusions
These findings suggest that addressing the high burden of poorly controlled asthma, including curbing high SABA use and its associated risk of exacerbations, may significantly alleviate asthma care-related carbon emissions. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Wilkinson, A. J. K., Maslova, E., Janson, C., Radhakrishnan, V., Quint, J. K., Budgen, N., Tran, T. N., Xu, Y., Menzies-Gow, A., Bell, J. P. Tags: Open access, Press releases, Thorax Asthma Source Type: research
Impact of sex on severe asthma: a cross-sectional retrospective analysis of UK primary and specialist care
Conclusions
Females had increased symptoms and were more likely to be obese despite higher FEV1% predicted and lower type 2 biomarkers with consistent and clinically important differences across both datasets. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Loewenthal, L., Busby, J., McDowell, R., Brown, T., Burhan, H., Chaudhuri, R., Dennison, P., Dodd, J. W., Doe, S., Faruqi, S., Gore, R., Idris, E., Jackson, D. J., Patel, M., Pantin, T., Pavord, I., Pfeffer, P. E., Price, D. B., Rupani, H., Siddiqui, S., Tags: Thorax Asthma Source Type: research
Use of inhaled corticosteroids and the risk of hospitalisation for pneumonia in children with asthma: a nationwide cohort study
Conclusions
In this nationwide cohort study, we found no evidence of an association between ICS use and the risk of hospitalisation for pneumonia among children with asthma, as compared with no use. (Source: Thorax)
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Sielinou Kamgang, K.-H., Rhedin, S. A., Almqvist, C., Wintzell, V. Tags: Open access, Thorax Asthma Source Type: research
Unravelling the obesity-asthma connection in childhood and adolescence: does body shape matter?
Given the concurrent worldwide epidemics of childhood obesity and asthma, it is perhaps not surprising that the two have been inextricably linked in the minds of many. Indeed, there is good evidence to suggest that adiposity in childhood is associated with an increased risk of developing asthma.1 2 Several longitudinal studies conducted in population-based cohorts have demonstrated that childhood obesity precedes incident asthma. One such study, from Taiwan, found that adiposity gain before age 6 years was good at predicting childhood-onset asthma, while adiposity gain during the prepubertal period was best at predicting y...
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Morgan, A. D. Tags: Thorax Editorial Source Type: research
Impacts of sex and gender on severe asthma
For decades, the unwritten rule for asthma management was ‘Keep it Simple’, with clinicians largely trying to apply a one-size-fits-all stepwise approach to hundreds of millions of people across the globe. More recently, our broader understanding, increasing array of targeted therapies, and relatively stagnant outcomes have led to a greater acknowledgement of the complexity that needs to be addressed.1 However, despite progress, our therapeutic pathways do not account for some basic patient characteristics such as sex. The impacts of sex and gender on asthma pathogenesis, prevalence and manifestation throughout...
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Wang, K. C. W., Blakey, J. D. Tags: Thorax Editorial Source Type: research
Does ICS treatment increase the risk of pneumonia in asthma?
Patients with asthma have an increased risk of being hospitalised for pneumonia. For example, in a study based on the Respiratory Health In Northern Europe data set, Ekbom et al found that adults with asthma had a more than three times higher risk (HR (3.35 (95% CI 1.97 to 5.02)) of hospitalisation for pneumonia than non-asthmatics.1 Kankaanranta et al also found a high incidence of pneumonia in people with asthma when using data from the National Finnish Register of Health Care.2 In that study, the incidence of pneumonia was higher in those with more severe asthma than in the group with non-severe disease. Likewise, Ekbom...
Source: Thorax - April 15, 2024 Category: Respiratory Medicine Authors: Janson, C. Tags: Thorax Editorial Source Type: research
