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Decoding cocaine-induced proteomic adaptations in the mouse nucleus accumbens | Science Signaling
Proteomics analysis of subcellular fractions of mouse brain may reveal clues for treating cocaine addiction. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 16, 2024 Category: Science Source Type: news

EGFR-dependent endocytosis of Wnt9a and Fzd9b promotes β-catenin signaling during hematopoietic stem cell development in zebrafish | Science Signaling
Fzd9b signaling induced by the ligand Wnt9a requires their endocytosis in an EGFR-dependent manner. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 16, 2024 Category: Science Source Type: news

Taking down tumors takes atypical integrins | Science Signaling
An unexpected integrin pairing enhances T cell receptor signaling and cytotoxicity in antitumor T cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 16, 2024 Category: Science Source Type: news

Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition | Science Signaling
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 9, 2024 Category: Science Source Type: news

Miz1 represses type I interferon production and limits viral clearance during influenza A virus infection | Science Signaling
A transcription factor implicated in bacterial immunity inhibits host responses during influenza virus infection. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 9, 2024 Category: Science Source Type: news

Sensing stretch to suppress appetite | Science Signaling
Food intake activates a mechanosensitive ion channel that inhibits ghrelin production and reduces appetite. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 9, 2024 Category: Science Source Type: news

The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation | Science Signaling
Extracellular ferritin promotes inflammation in the liver by inducing IL-1 β release from hepatic stellate cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 2, 2024 Category: Science Source Type: news

Lipid drops in on Alzheimer ’s disease | Science Signaling
Microglial lipid droplet accumulation leads to increased neurotoxicity in an APOE-dependent manner. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - April 2, 2024 Category: Science Source Type: news

Glucosylceramide accumulation in microglia triggers STING-dependent neuroinflammation and neurodegeneration in mice | Science Signaling
Blocking lipid-induced STING signaling in microglia may slow Gaucher disease –associated neuronal loss. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 26, 2024 Category: Science Source Type: news

Biasing microglia to help, not hurt | Science Signaling
Blocking complement signaling biases microglia to destroy amyloid aggregates, not neuronal synapses. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 26, 2024 Category: Science Source Type: news

CXCL17 is an allosteric inhibitor of CXCR4 through a mechanism of action involving glycosaminoglycans | Science Signaling
The chemokine CXCL17 may cooperate with glycosaminoglycan-containing proteins to inhibit the receptor CXCR4. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 19, 2024 Category: Science Source Type: news

Exercise-induced BDNF promotes PPAR δ-dependent reprogramming of lipid metabolism in skeletal muscle during exercise recovery | Science Signaling
BDNF generated by skeletal muscle promotes metabolic reprogramming that enables recovery after exercise. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 19, 2024 Category: Science Source Type: news

Polarizing itch | Science Signaling
An itch-associated GPCR on neutrophils controls their activation during bacterial infection. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 19, 2024 Category: Science Source Type: news

Cancer-associated fibroblasts produce matrix-bound vesicles that influence endothelial cell function | Science Signaling
Protein transfer through matrix-bound vesicles from CAFs enhances monocyte adhesion to endothelial cells. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 12, 2024 Category: Science Source Type: news

The activation of the adaptor protein STING depends on its interactions with the phospholipid PI4P | Science Signaling
The phospholipid PI4P can enhance STING activation by increasing its recruitment to the Golgi apparatus. (Source: Signal Transduction Knowledge Environment)
Source: Signal Transduction Knowledge Environment - March 12, 2024 Category: Science Source Type: news