Reviews in Endocrine and Metabolic Disorders 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Pitfalls in the lab assessment of hypopituitarism
AbstractThe diagnostic approach to hypopituitarism involves many disciplines. Clinical symptoms rarely are specific. Imaging techniques are helpful but cannot prove the specific functional defects. Therefore, the definitive diagnosis of pituitary insufficiency is largely based on laboratory tests. However, also laboratory methods come with inherent limitations, and it is essential for the clinician to know and recognize typical pitfalls. Most factors potentially impairing the quality of hormone measurements are introduced in the preanalytical phase, i.e. before the hormones are measured by the laboratory. For example, the ...
Source: Reviews in Endocrine and Metabolic Disorders - April 13, 2024 Category: Endocrinology Source Type: research
Ethnic differences in metabolic syndrome in high-income countries: A systematic review and meta-analysis
AbstractThis review aimed to systematically quantify the differences in Metabolic Syndrome (MetS) prevalence across various ethnic groups in high-income countries by sex, and to evaluate the overall prevalence trends from 1996 to 2022. We conducted a systematic literature review using MEDLINE, Web of Science Core Collection, CINAHL, and the Cochrane Library, focusing on studies about MetS prevalence among ethnic groups in high-income countries. We pooled 23 studies that used NCEP-ATP III criteria and included 147,756 healthy participants aged 18 and above. We calculated pooled prevalence estimates and 95% confidence interv...
Source: Reviews in Endocrine and Metabolic Disorders - April 10, 2024 Category: Endocrinology Source Type: research
Diagnosis and therapeutic approach to bone health in patients with hypopituitarism
AbstractThe results of many studies in recent years indicate a significant impact of pituitary function on bone health. The proper function of the pituitary gland has a significant impact on the growth of the skeleton and the appearance of sexual dimorphism. It is also responsible for achieving peak bone mass, which protects against the development of osteoporosis and fractures later in life. It is also liable for the proper remodeling of the skeleton, which is a physiological mechanism managing the proper mechanical resistance of bones and the possibility of its regeneration after injuries. Pituitary diseases causing hypo...
Source: Reviews in Endocrine and Metabolic Disorders - April 3, 2024 Category: Endocrinology Source Type: research
Endocrine involvement in hepatic glycogen storage diseases: pathophysiology and implications for care
AbstractHepatic glycogen storage diseases constitute a group of disorders due to defects in the enzymes and transporters involved in glycogen breakdown and synthesis in the liver. Although hypoglycemia and hepatomegaly are the primary manifestations of (most of) hepatic GSDs, involvement of the endocrine system has been reported at multiple levels in individuals with hepatic GSDs. While some endocrine abnormalities (e.g., hypothalamic ‑pituitary axis dysfunction in GSD I) can be direct consequence of the genetic defect itself, others (e.g., osteopenia in GSD Ib, insulin-resistance in GSD I and GSD III) may be triggered b...
Source: Reviews in Endocrine and Metabolic Disorders - April 1, 2024 Category: Endocrinology Source Type: research
An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications
AbstractAdipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue, is vital in modulating whole-body energy metabolism. While WAT primarily stores energy, BAT dissipates energy as heat for thermoregulation. Beige adipose tissue is a hybrid form of adipose tissue that shares characteristics with WAT and BAT. Dysregulation of adipose tissue metabolism is linked to various disorders, including obesity, type 2 diabetes, cardiovascular diseases, cancer, and infertility. Both brown and beige adipocytes secrete multiple molecules, such as batokines, packaged in extracellular vesicl...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
Pulling the trigger: Noncoding RNAs in white adipose tissue browning
AbstractWhite adipose tissue (WAT) serves as the primary site for energy storage and endocrine regulation in mammals, while brown adipose tissue (BAT) is specialized for thermogenesis and energy expenditure. The conversion of white adipocytes to brown-like fat cells, known as browning, has emerged as a promising therapeutic strategy for reversing obesity and its associated co-morbidities. Noncoding RNAs (ncRNAs) are a class of transcripts that do not encode proteins but exert regulatory functions on gene expression at various levels. Recent studies have shed light on the involvement of ncRNAs in adipose tissue development,...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
Epigenetic programming for obesity and noncommunicable disease: From womb to tomb
AbstractSeveral epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure to stressors during development and health outcomes later in life. The characterization of these susceptible phases, such as preconception, gestation, lactation and adolescence, and the understanding of factors that influence the risk of an adult individual for developing obesity, metabolic and cardiovascular diseases, is the focus of the DOHaD (Developmental Origins of Health and Disease) research line. In this sense, advancements in molecular biology techniques have contributed significantly t...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
The kisspeptin system in and beyond reproduction: exploring intricate pathways and potential links between endometriosis and polycystic ovary syndrome
AbstractEndometriosis and polycystic ovary syndrome (PCOS) are two common female reproductive disorders with a significant impact on the health and quality of life of women affected. A novel hypothesis by evolutionary biologists suggested that these two diseases are inversely related to one another, representing a pair of diametrical diseases in terms of opposite alterations in reproductive physiological processes but also contrasting phenotypic traits. However, to fully explain the phenotypic features observed in women with these conditions, we need to establish a potential nexus system between the reproductive system and...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion
AbstractUndernutrition is still a recurring nutritional problem in low and middle-income countries. It is directly associated with the social and economic sphere, but it can also negatively impact the health of the population. In this sense, it is believed that undernourished individuals may be more susceptible to the development of non-communicable diseases, such as diabetes mellitus, throughout life. This hypothesis was postulated and confirmed until today by several studies that demonstrate that experimental models submitted to protein undernutrition present alterations in glycemic homeostasis linked, in part, to the re...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
The effect of bariatric surgery on the expression of gastrointestinal taste receptors: A systematic review
AbstractGastrointestinal nutrient sensing via taste receptors may contribute to weight loss, metabolic improvements, and a reduced preference for sweet and fatty foods following bariatric surgery. This review aimed to investigate the effect of bariatric surgery on the expression of oral and post-oral gastrointestinal taste receptors and associations between taste receptor alterations and clinical outcomes of bariatric surgery. A systematic review was conducted to capture data from both human and animal studies on changes in the expression of taste receptors in oral or post-oral gastrointestinal tissue following any type of...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing
AbstractOsteoarthritis (OA) is an incapacitating and one of the most common physically degenerative conditions with an assorted etiology and a highly complicated molecular mechanism that to date lacks an efficient treatment. The capacity to design biological networks and accurately modify existing genomic sites holds an apt potential for applications across medical and biotechnological sciences. One of these highly specific genomes editing technologies is the CRISPR/Cas9 mechanism, referred to as the clustered regularly interspaced short palindromic repeats, which is a defense mechanism constituted by CRISPR associated pro...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors
AbstractAs the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have emerged, and interest into a gender-driven management of these tumors has grown with the aim to improve survival and quality of life of these patients. Somatostatin Analogues represent the first line of systemic treatment of both functional and non-functional neuroendocrine tumors, through the expression of somatostatin receptors (SSTRs) in the tumor cells, and proved effective in controlling hormonal hypersecretion and inhibiting tumor growth, improving progression-free survival and overall surv...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
Circadian alignment of food intake and glycaemic control by time-restricted eating: A systematic review and meta-analysis
AbstractDaily rhythms of metabolic function are supported by molecular circadian clock systems that are strongly regulated by feeding and fasting. Intermittent fasting diets have been associated with weight loss and improved metabolism. However, the effects of time-restricted eating (TRE) on glycemic parameters are still under debate. In this review, we aim to systematically analyze the effects of TRE on glycemic parameters. We searched on PubMed, EMBASE, and the Cochrane Library for controlled studies in which subjects followed TRE for at least 4 weeks. 20 studies were included in the qualitative systematic review, and ...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy
AbstractDiabetes mellitus is a metabolic disorder denoted by chronic hyperglycemia that drives maladaptive structural changes and functional damage to the vasculature. Attenuation of this pathological remodeling of blood vessels remains an unmet target owing to paucity of information on the metabolic signatures of this process. Ca2+/calmodulin-dependent kinase II (CaMKII) is expressed in the vasculature and is implicated in the control of blood vessels homeostasis. Recently, CaMKII has attracted a special attention in view of its chronic upregulated activity in diabetic tissues, yet its role in the diabetic vasculature rem...
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
Correction to: Preoperative systemic inflammatory markers as prognostic factors in differentiated thyroid cancer: a systematic review and meta-analysis
(Source: Reviews in Endocrine and Metabolic Disorders)
Source: Reviews in Endocrine and Metabolic Disorders - March 26, 2024 Category: Endocrinology Source Type: research
