Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure-activity relationship, and prospects for clinical advancement
This article aimed to comprehensively review the anticancer properties of Rg5, focusing on action mechanisms, structure-activity relationship (SAR), and pharmacokinetics attributes. The in vitro and in vivo activities of Rg5 have been proven against several cancer types, such as breast, liver, lung, bone, and gastrointestinal (GI) cancers. The modulation of multiple signaling pathways critical for cancer growth and survival mediates these activities. Nevertheless, human clinical studies of Rg5 have not been addressed before, and there is still considerable ambiguity regarding its pharmacokinetics properties. In addition, a...
Source: Pharmacological Reports - March 25, 2024 Category: Drugs & Pharmacology Authors: Tilal Elsaman Ali Mahmoud Muddathir Ebtihal A M Mohieldin Irmanida Batubara Min Rahminiwati Kosei Yamauchi Magdi Awadalla Mohamed Shadila Fira Asoka Dietrich B üsselberg Solomon Habtemariam Javad Sharifi-Rad Source Type: research
Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats
CONCLUSIONS: The studies show that CBD can protect the liver from CH probably through attenuating PH, protective effects on the RV, and possibly direct anti-inflammatory effects on liver tissue through regulation of the NF-κB pathway.PMID:38519732 | DOI:10.1007/s43440-024-00579-4 (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 23, 2024 Category: Drugs & Pharmacology Authors: Anna Krzy żewska Marta Baranowska-Kuczko Anna Galicka Irena Kasacka Krzysztof Mi ńczuk Hanna Koz łowska Source Type: research
The effect of valproate on the amino acids, monoamines, and kynurenic acid concentrations in brain structures involved in epileptogenesis in the pentylenetetrazol-kindled rats
CONCLUSIONS: Our results indicate that a single administration of VPA in the PTZ-kindled rats restored proper balance between excitatory (decreasing the level of ASP) and inhibitory neurotransmission (increased concentration GABA, KYNA) and affecting serotoninergic neurotransmission in the prefrontal cortex, hippocampus, amygdala, and striatum.PMID:38519733 | DOI:10.1007/s43440-024-00573-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 23, 2024 Category: Drugs & Pharmacology Authors: Aleksandra Wis łowska-Stanek Danuta Turzy ńska Alicja Sobolewska Karolina Ko łosowska Janusz Szyndler Anna Sk órzewska Piotr Maciejak Source Type: research
Cannabidiol may prevent the development of congestive hepatopathy secondary to right ventricular hypertrophy associated with pulmonary hypertension in rats
CONCLUSIONS: The studies show that CBD can protect the liver from CH probably through attenuating PH, protective effects on the RV, and possibly direct anti-inflammatory effects on liver tissue through regulation of the NF-κB pathway.PMID:38519732 | DOI:10.1007/s43440-024-00579-4 (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 23, 2024 Category: Drugs & Pharmacology Authors: Anna Krzy żewska Marta Baranowska-Kuczko Anna Galicka Irena Kasacka Krzysztof Mi ńczuk Hanna Koz łowska Source Type: research
The effect of valproate on the amino acids, monoamines, and kynurenic acid concentrations in brain structures involved in epileptogenesis in the pentylenetetrazol-kindled rats
CONCLUSIONS: Our results indicate that a single administration of VPA in the PTZ-kindled rats restored proper balance between excitatory (decreasing the level of ASP) and inhibitory neurotransmission (increased concentration GABA, KYNA) and affecting serotoninergic neurotransmission in the prefrontal cortex, hippocampus, amygdala, and striatum.PMID:38519733 | DOI:10.1007/s43440-024-00573-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 23, 2024 Category: Drugs & Pharmacology Authors: Aleksandra Wis łowska-Stanek Danuta Turzy ńska Alicja Sobolewska Karolina Ko łosowska Janusz Szyndler Anna Sk órzewska Piotr Maciejak Source Type: research
Migraine and the microbiota. Can probiotics be beneficial in its prevention? - a narrative review
Pharmacol Rep. 2024 Mar 19. doi: 10.1007/s43440-024-00584-7. Online ahead of print.ABSTRACTMigraine is a recurrent disease of the central nervous system that affects an increasing number of people worldwide causing a continuous increase in the costs of treatment. The mechanisms underlying migraine are still unclear but recent reports show that people with migraine may have an altered composition of the intestinal microbiota. It is well established that the gut-brain axis is involved in many neurological diseases, and probiotic supplementation may be an interesting treatment option for these conditions. This review collects...
Source: Pharmacological Reports - March 19, 2024 Category: Drugs & Pharmacology Authors: Aneta Kiecka Marian Szczepanik Source Type: research
Migraine and the microbiota. Can probiotics be beneficial in its prevention? - a narrative review
Pharmacol Rep. 2024 Mar 19. doi: 10.1007/s43440-024-00584-7. Online ahead of print.ABSTRACTMigraine is a recurrent disease of the central nervous system that affects an increasing number of people worldwide causing a continuous increase in the costs of treatment. The mechanisms underlying migraine are still unclear but recent reports show that people with migraine may have an altered composition of the intestinal microbiota. It is well established that the gut-brain axis is involved in many neurological diseases, and probiotic supplementation may be an interesting treatment option for these conditions. This review collects...
Source: Pharmacological Reports - March 19, 2024 Category: Drugs & Pharmacology Authors: Aneta Kiecka Marian Szczepanik Source Type: research
Migraine and the microbiota. Can probiotics be beneficial in its prevention? - a narrative review
Pharmacol Rep. 2024 Mar 19. doi: 10.1007/s43440-024-00584-7. Online ahead of print.ABSTRACTMigraine is a recurrent disease of the central nervous system that affects an increasing number of people worldwide causing a continuous increase in the costs of treatment. The mechanisms underlying migraine are still unclear but recent reports show that people with migraine may have an altered composition of the intestinal microbiota. It is well established that the gut-brain axis is involved in many neurological diseases, and probiotic supplementation may be an interesting treatment option for these conditions. This review collects...
Source: Pharmacological Reports - March 19, 2024 Category: Drugs & Pharmacology Authors: Aneta Kiecka Marian Szczepanik Source Type: research
Migraine and the microbiota. Can probiotics be beneficial in its prevention? - a narrative review
Pharmacol Rep. 2024 Mar 19. doi: 10.1007/s43440-024-00584-7. Online ahead of print.ABSTRACTMigraine is a recurrent disease of the central nervous system that affects an increasing number of people worldwide causing a continuous increase in the costs of treatment. The mechanisms underlying migraine are still unclear but recent reports show that people with migraine may have an altered composition of the intestinal microbiota. It is well established that the gut-brain axis is involved in many neurological diseases, and probiotic supplementation may be an interesting treatment option for these conditions. This review collects...
Source: Pharmacological Reports - March 19, 2024 Category: Drugs & Pharmacology Authors: Aneta Kiecka Marian Szczepanik Source Type: research
Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
CONCLUSIONS: HYGC is a promising candidate to counteract corticosterone-induced apoptosis and oxidative stress. Autophagy and MAPK pathway inhibition contribute to the protective effects of HYGC. Our findings highlight the potential of HYGC as a therapeutic agent for stress-related disorders and serve as a stepping stone for further exploration and development of stress management strategies.PMID:38498259 | DOI:10.1007/s43440-024-00572-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 18, 2024 Category: Drugs & Pharmacology Authors: Jongtae Roh Jun-Pil Jang Taehoon Oh Jihong Kim Byeongsan Lee Young-Soo Hong Jae-Hyuk Jang Sung-Kyun Ko Source Type: research
Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy
Pharmacol Rep. 2024 Mar 18. doi: 10.1007/s43440-024-00585-6. Online ahead of print.ABSTRACTThe COVID-19 pandemic that started in 2019 and resulted in significant morbidity and mortality continues to be a significant global health challenge, characterized by inflammation, oxidative stress, and immune system dysfunction.. Developing therapies for preventing or treating COVID-19 remains an important goal for pharmacology and drug development research. Polyphenols are effective against various viral infections and can be extracted and isolated from plants without losing their therapeutic potential. Researchers have developed m...
Source: Pharmacological Reports - March 18, 2024 Category: Drugs & Pharmacology Authors: Mahdi Vajdi Arash Karimi Shirin Hassanizadeh Mahdieh Abbasalizad Farhangi Mohammad Bagherniya Gholamreza Askari Basil D Roufogalis Neal M Davies Amirhossein Sahebkar Source Type: research
Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
CONCLUSIONS: HYGC is a promising candidate to counteract corticosterone-induced apoptosis and oxidative stress. Autophagy and MAPK pathway inhibition contribute to the protective effects of HYGC. Our findings highlight the potential of HYGC as a therapeutic agent for stress-related disorders and serve as a stepping stone for further exploration and development of stress management strategies.PMID:38498259 | DOI:10.1007/s43440-024-00572-x (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 18, 2024 Category: Drugs & Pharmacology Authors: Jongtae Roh Jun-Pil Jang Taehoon Oh Jihong Kim Byeongsan Lee Young-Soo Hong Jae-Hyuk Jang Sung-Kyun Ko Source Type: research
Effect of polyphenols against complications of COVID-19: current evidence and potential efficacy
Pharmacol Rep. 2024 Mar 18. doi: 10.1007/s43440-024-00585-6. Online ahead of print.ABSTRACTThe COVID-19 pandemic that started in 2019 and resulted in significant morbidity and mortality continues to be a significant global health challenge, characterized by inflammation, oxidative stress, and immune system dysfunction.. Developing therapies for preventing or treating COVID-19 remains an important goal for pharmacology and drug development research. Polyphenols are effective against various viral infections and can be extracted and isolated from plants without losing their therapeutic potential. Researchers have developed m...
Source: Pharmacological Reports - March 18, 2024 Category: Drugs & Pharmacology Authors: Mahdi Vajdi Arash Karimi Shirin Hassanizadeh Mahdieh Abbasalizad Farhangi Mohammad Bagherniya Gholamreza Askari Basil D Roufogalis Neal M Davies Amirhossein Sahebkar Source Type: research
Liquid chromatography-tandem mass spectrometry method for mycophenolic acid and its glucuronide determination in saliva samples from children with nephrotic syndrome
CONCLUSIONS: The evaluated LC-MS/MS method has met the validation requirements for saliva MPA and MPAG determination in children with nephrotic syndrome. Further studies are needed to explore plasma-saliva correlations and assess their potential contribution to MPA monitoring.PMID:38485859 | DOI:10.1007/s43440-024-00574-9 (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 15, 2024 Category: Drugs & Pharmacology Authors: Joanna Sobiak Matylda Resztak Weronika Sikora Jacek Zachwieja Danuta Ostalska-Nowicka Source Type: research
Liquid chromatography-tandem mass spectrometry method for mycophenolic acid and its glucuronide determination in saliva samples from children with nephrotic syndrome
CONCLUSIONS: The evaluated LC-MS/MS method has met the validation requirements for saliva MPA and MPAG determination in children with nephrotic syndrome. Further studies are needed to explore plasma-saliva correlations and assess their potential contribution to MPA monitoring.PMID:38485859 | DOI:10.1007/s43440-024-00574-9 (Source: Pharmacological Reports)
Source: Pharmacological Reports - March 15, 2024 Category: Drugs & Pharmacology Authors: Joanna Sobiak Matylda Resztak Weronika Sikora Jacek Zachwieja Danuta Ostalska-Nowicka Source Type: research
