Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms
Pharmacol Rep. 2024 Apr 12. doi: 10.1007/s43440-024-00593-6. Online ahead of print.ABSTRACTOral diseases, including periodontal disorders, oral cancer, periodontitis, and mucositis are the major challenges for both patients and healthcare providers. These conditions often involve inflammation, oxidative stress, and impaired cellular processes, leading to symptoms ranging from discomfort to severe debilitation. Conventional treatments for such oral diseases exhibit constraints, prompting the investigation of innovative therapeutic approaches. Considering the anti-inflammatory, anti-oxidant, and anti-cancer effects of melato...
Source: Pharmacological Reports - April 12, 2024 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Ali Jamshidi Naeini Mohammad Sheibani Babak Gholamine Russel J Reiter Saeed Mehrzadi Source Type: research
Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms
Pharmacol Rep. 2024 Apr 12. doi: 10.1007/s43440-024-00593-6. Online ahead of print.ABSTRACTOral diseases, including periodontal disorders, oral cancer, periodontitis, and mucositis are the major challenges for both patients and healthcare providers. These conditions often involve inflammation, oxidative stress, and impaired cellular processes, leading to symptoms ranging from discomfort to severe debilitation. Conventional treatments for such oral diseases exhibit constraints, prompting the investigation of innovative therapeutic approaches. Considering the anti-inflammatory, anti-oxidant, and anti-cancer effects of melato...
Source: Pharmacological Reports - April 12, 2024 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Ali Jamshidi Naeini Mohammad Sheibani Babak Gholamine Russel J Reiter Saeed Mehrzadi Source Type: research
Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer
CONCLUSION: The Mediator kinase module is deregulated in a sub-set of colorectal cancers with differences observed in genomically defined groups. These variations may result in differences in sensitivity to targeted therapies and may have to be taken into consideration as such therapies are developed.PMID:38602606 | DOI:10.1007/s43440-024-00589-2 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 11, 2024 Category: Drugs & Pharmacology Authors: Ioannis A Voutsadakis Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Redox homeostasis in human renal cells that had been treated with amphotericin B in combination with selected 1,3,4-thiadiazole derivatives
CONCLUSIONS: The results confirmed that thiadiazoles can stimulate the RPTEC cells to defend against the oxidative stress that is generated by AmB. In addition, together with the previously demonstrated synergistic antifungal activity, and low nephrotoxicity, these compounds have the potential to be used in new therapeutic strategies in the treatment of fungal infections.PMID:38587587 | DOI:10.1007/s43440-024-00592-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 8, 2024 Category: Drugs & Pharmacology Authors: Magdalena Kimsa-Dudek Celina Kruszniewska-Rajs Jolanta Adamska Barbara Strza łka-Mrozik Arkadiusz Matwijczuk Dariusz Karcz Mariusz Gago ś Joanna Magdalena Gola Source Type: research
Correction: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
Pharmacol Rep. 2024 Apr 4. doi: 10.1007/s43440-024-00591-8. Online ahead of print.NO ABSTRACTPMID:38573564 | DOI:10.1007/s43440-024-00591-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 4, 2024 Category: Drugs & Pharmacology Authors: Jongtae Roh Jun-Pil Jang Taehoon Oh Jihong Kim Byeongsan Lee Young-Soo Hong Jae-Hyuk Jang Sung-Kyun Ko Source Type: research
Correction: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
Pharmacol Rep. 2024 Apr 4. doi: 10.1007/s43440-024-00591-8. Online ahead of print.NO ABSTRACTPMID:38573564 | DOI:10.1007/s43440-024-00591-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 4, 2024 Category: Drugs & Pharmacology Authors: Jongtae Roh Jun-Pil Jang Taehoon Oh Jihong Kim Byeongsan Lee Young-Soo Hong Jae-Hyuk Jang Sung-Kyun Ko Source Type: research
Correction: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
Pharmacol Rep. 2024 Apr 4. doi: 10.1007/s43440-024-00591-8. Online ahead of print.NO ABSTRACTPMID:38573564 | DOI:10.1007/s43440-024-00591-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 4, 2024 Category: Drugs & Pharmacology Authors: Jongtae Roh Jun-Pil Jang Taehoon Oh Jihong Kim Byeongsan Lee Young-Soo Hong Jae-Hyuk Jang Sung-Kyun Ko Source Type: research
Correction: Protective effect of hygrolansamycin C against corticosterone-induced toxicity and oxidative stress-mediated via autophagy and the MAPK signaling pathway
Pharmacol Rep. 2024 Apr 4. doi: 10.1007/s43440-024-00591-8. Online ahead of print.NO ABSTRACTPMID:38573564 | DOI:10.1007/s43440-024-00591-8 (Source: Pharmacological Reports)
Source: Pharmacological Reports - April 4, 2024 Category: Drugs & Pharmacology Authors: Jongtae Roh Jun-Pil Jang Taehoon Oh Jihong Kim Byeongsan Lee Young-Soo Hong Jae-Hyuk Jang Sung-Kyun Ko Source Type: research
Neuroprotective effect of apelin-13 and other apelin forms-a review
Pharmacol Rep. 2024 Apr 3. doi: 10.1007/s43440-024-00587-4. Online ahead of print.ABSTRACTNeurodegenerative diseases, which occur when neurons begin to deteriorate, affect millions of people worldwide. These age-related disorders are becoming more common partly because the elderly population has increased in recent years. While no treatments are accessible, every year an increasing number of therapeutic and supportive options become available. Various substances that may have neuroprotective effects are currently being researched. One of them is apelin. This review aims to illustrate the results of research on the neuropro...
Source: Pharmacological Reports - April 3, 2024 Category: Drugs & Pharmacology Authors: Katarzyna Kami ńska Hubert Borzuta Kasper Buczma Agnieszka Cudnoch-J ędrzejewska Source Type: research
Neuroprotective effect of apelin-13 and other apelin forms-a review
Pharmacol Rep. 2024 Apr 3. doi: 10.1007/s43440-024-00587-4. Online ahead of print.ABSTRACTNeurodegenerative diseases, which occur when neurons begin to deteriorate, affect millions of people worldwide. These age-related disorders are becoming more common partly because the elderly population has increased in recent years. While no treatments are accessible, every year an increasing number of therapeutic and supportive options become available. Various substances that may have neuroprotective effects are currently being researched. One of them is apelin. This review aims to illustrate the results of research on the neuropro...
Source: Pharmacological Reports - April 3, 2024 Category: Drugs & Pharmacology Authors: Katarzyna Kami ńska Hubert Borzuta Kasper Buczma Agnieszka Cudnoch-J ędrzejewska Source Type: research
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors
Regul Toxicol Pharmacol. 2024 Mar 26;149:105598. doi: 10.1016/j.yrtph.2024.105598. Online ahead of print.ABSTRACTIn 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs) that interact with the aryl hydrocarbon receptor (AHR)]. Their update used sophisticated statistical analysis of hundreds of published studies that reported estimation of 'Relative Effective Potency' (REP) values for individual DLC congeners. The weighting scheme used in their assessment of ea...
Source: Pharmacological Reports - March 28, 2024 Category: Drugs & Pharmacology Authors: David L Eaton Ted W Simon Norbert E Kaminski Gary H Perdew Daniel W Nebert Source Type: research
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors
Regul Toxicol Pharmacol. 2024 Mar 26;149:105598. doi: 10.1016/j.yrtph.2024.105598. Online ahead of print.ABSTRACTIn 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs) that interact with the aryl hydrocarbon receptor (AHR)]. Their update used sophisticated statistical analysis of hundreds of published studies that reported estimation of 'Relative Effective Potency' (REP) values for individual DLC congeners. The weighting scheme used in their assessment of ea...
Source: Pharmacological Reports - March 28, 2024 Category: Drugs & Pharmacology Authors: David L Eaton Ted W Simon Norbert E Kaminski Gary H Perdew Daniel W Nebert Source Type: research
Species differences in specific ligand-binding affinity and activation of AHR: The biological basis for calculation of relative effective potencies and toxic equivalence factors
Regul Toxicol Pharmacol. 2024 Mar 26;149:105598. doi: 10.1016/j.yrtph.2024.105598. Online ahead of print.ABSTRACTIn 2022 the World Health Organization (WHO) published updated 'Toxic Equivalence Factors' (TEFs) for a wide variety of chlorinated dioxins, dibenzofurans and PCBs [collectively referred to as 'dioxin-like chemicals'; DLCs) that interact with the aryl hydrocarbon receptor (AHR)]. Their update used sophisticated statistical analysis of hundreds of published studies that reported estimation of 'Relative Effective Potency' (REP) values for individual DLC congeners. The weighting scheme used in their assessment of ea...
Source: Pharmacological Reports - March 28, 2024 Category: Drugs & Pharmacology Authors: David L Eaton Ted W Simon Norbert E Kaminski Gary H Perdew Daniel W Nebert Source Type: research
