The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study
CONCLUSIONS: Based on the spectroscopic and microcalorimetric data, both KAN and NEO can be considered modulators of the HSA antioxidant activity.PMID:37704832 | DOI:10.1007/s43440-023-00529-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 13, 2023 Category: Drugs & Pharmacology Authors: Wojciech Rog óż Kinga Mac Aleksandra Owczarzy Karolina Kulig Jadwiga Po życka Ma łgorzata Maciążek-Jurczyk Source Type: research
The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study
CONCLUSIONS: Based on the spectroscopic and microcalorimetric data, both KAN and NEO can be considered modulators of the HSA antioxidant activity.PMID:37704832 | DOI:10.1007/s43440-023-00529-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 13, 2023 Category: Drugs & Pharmacology Authors: Wojciech Rog óż Kinga Mac Aleksandra Owczarzy Karolina Kulig Jadwiga Po życka Ma łgorzata Maciążek-Jurczyk Source Type: research
The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study
CONCLUSIONS: Based on the spectroscopic and microcalorimetric data, both KAN and NEO can be considered modulators of the HSA antioxidant activity.PMID:37704832 | DOI:10.1007/s43440-023-00529-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 13, 2023 Category: Drugs & Pharmacology Authors: Wojciech Rog óż Kinga Mac Aleksandra Owczarzy Karolina Kulig Jadwiga Po życka Ma łgorzata Maciążek-Jurczyk Source Type: research
The effect of selected aminoglycoside antibiotics on human serum albumin antioxidant activity: a spectroscopic and calorimetric comparative study
CONCLUSIONS: Based on the spectroscopic and microcalorimetric data, both KAN and NEO can be considered modulators of the HSA antioxidant activity.PMID:37704832 | DOI:10.1007/s43440-023-00529-6 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 13, 2023 Category: Drugs & Pharmacology Authors: Wojciech Rog óż Kinga Mac Aleksandra Owczarzy Karolina Kulig Jadwiga Po życka Ma łgorzata Maciążek-Jurczyk Source Type: research
HDAC3 inhibition protects against peripheral and central alterations in an animal model of obesity
CONCLUSION: Therefore, HDAC3 inhibition can represent a promising pharmacological target for the treatment of obesity.PMID:37698830 | DOI:10.1007/s43440-023-00528-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 12, 2023 Category: Drugs & Pharmacology Authors: Franci éle Romero Machado Silvana Peterini Boeira Vandreza Cardoso Bortolotto St ífani Machado Araujo M árcia Rósula Poetini Cristini Escobar Viana Marina Prigol Leandro Cattelan Souza Marcelo Gomes de Gomes Source Type: research
HDAC3 inhibition protects against peripheral and central alterations in an animal model of obesity
CONCLUSION: Therefore, HDAC3 inhibition can represent a promising pharmacological target for the treatment of obesity.PMID:37698830 | DOI:10.1007/s43440-023-00528-7 (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 12, 2023 Category: Drugs & Pharmacology Authors: Franci éle Romero Machado Silvana Peterini Boeira Vandreza Cardoso Bortolotto St ífani Machado Araujo M árcia Rósula Poetini Cristini Escobar Viana Marina Prigol Leandro Cattelan Souza Marcelo Gomes de Gomes Source Type: research
Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen-glucose deprivation condition
CONCLUSIONS: Together, this study revealed the protection of VPA in ex vivo OGD-induced pathological form of neuroplasticity and in vivo PTI-induced brain damage and motor dysfunction through rescuing GABAergic deficiency and the pathological hallmarks of ischemia.PMID:37695500 | DOI:10.1007/s43440-023-00525-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 11, 2023 Category: Drugs & Pharmacology Authors: Ming-Chia Chu Wei-Chang Mao Han-Fang Wu Yun-Chi Chang Ting-I Lu Chi-Wei Lee Yueh-Jung Chung Tsung-Han Hsieh Hsun-Shuo Chang Yih-Fung Chen Chia-Hsien Lin Chih-Wei Tang Hui-Ching Lin Source Type: research
Transient plasticity response is regulated by histone deacetylase inhibitor in oxygen-glucose deprivation condition
CONCLUSIONS: Together, this study revealed the protection of VPA in ex vivo OGD-induced pathological form of neuroplasticity and in vivo PTI-induced brain damage and motor dysfunction through rescuing GABAergic deficiency and the pathological hallmarks of ischemia.PMID:37695500 | DOI:10.1007/s43440-023-00525-w (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 11, 2023 Category: Drugs & Pharmacology Authors: Ming-Chia Chu Wei-Chang Mao Han-Fang Wu Yun-Chi Chang Ting-I Lu Chi-Wei Lee Yueh-Jung Chung Tsung-Han Hsieh Hsun-Shuo Chang Yih-Fung Chen Chia-Hsien Lin Chih-Wei Tang Hui-Ching Lin Source Type: research
Therapeutic implications of phosphorylation- and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration
Pharmacol Rep. 2023 Sep 9. doi: 10.1007/s43440-023-00526-9. Online ahead of print.ABSTRACTNeurodegeneration is a condition of the central nervous system (CNS) characterized by loss of neural structures and function. The most common neurodegenerative disorders (NDDs) include Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), multiple sclerosis (MS), motor neuron disorders, psychological disorders, dementia with vascular dementia (VaD), Lewy body dementia (DLB), epilepsy, cerebral ischemia, mental illness, and behavioral disorders. CREB (cAMP-response element-b...
Source: Pharmacological Reports - September 9, 2023 Category: Drugs & Pharmacology Authors: Nilima Khakha Heena Khan Amarjot Kaur Thakur Gurjeet Singh Source Type: research
Therapeutic implications of phosphorylation- and dephosphorylation-dependent factors of cAMP-response element-binding protein (CREB) in neurodegeneration
Pharmacol Rep. 2023 Sep 9. doi: 10.1007/s43440-023-00526-9. Online ahead of print.ABSTRACTNeurodegeneration is a condition of the central nervous system (CNS) characterized by loss of neural structures and function. The most common neurodegenerative disorders (NDDs) include Alzheimer's disease (AD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), multiple sclerosis (MS), motor neuron disorders, psychological disorders, dementia with vascular dementia (VaD), Lewy body dementia (DLB), epilepsy, cerebral ischemia, mental illness, and behavioral disorders. CREB (cAMP-response element-b...
Source: Pharmacological Reports - September 9, 2023 Category: Drugs & Pharmacology Authors: Nilima Khakha Heena Khan Amarjot Kaur Thakur Gurjeet Singh Source Type: research
Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
Pharmacol Rep. 2023 Sep 6. doi: 10.1007/s43440-023-00520-1. Online ahead of print.ABSTRACTDisruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota have opened the scope of further understanding the various communications between these microbiota and skin immune cells. Vitamins, being one of the important micronutrients, have been reported to exert antioxidant, anti-inflammatory, and a...
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Mahika Joshi Priyanka Hiremath Jeena John Niraja Ranadive Krishnadas Nandakumar Jayesh Mudgal Source Type: research
Pten knockout affects drug resistance differently in melanoma and kidney cancer
CONCLUSIONS: The results confirmed heterogenous cell responses to PTEN loss, which may lead to a better understanding of the role of PTEN in particular types of tumors and points to PTEN as a therapeutic target for personalized medicine.PMID:37673853 | DOI:10.1007/s43440-023-00523-y (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Klaudia Brodaczewska Aleksandra Majewska Aleksandra Filipiak-Duliban Claudine Kieda Source Type: research
Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
Pharmacol Rep. 2023 Sep 6. doi: 10.1007/s43440-023-00520-1. Online ahead of print.ABSTRACTDisruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota have opened the scope of further understanding the various communications between these microbiota and skin immune cells. Vitamins, being one of the important micronutrients, have been reported to exert antioxidant, anti-inflammatory, and a...
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Mahika Joshi Priyanka Hiremath Jeena John Niraja Ranadive Krishnadas Nandakumar Jayesh Mudgal Source Type: research
Pten knockout affects drug resistance differently in melanoma and kidney cancer
CONCLUSIONS: The results confirmed heterogenous cell responses to PTEN loss, which may lead to a better understanding of the role of PTEN in particular types of tumors and points to PTEN as a therapeutic target for personalized medicine.PMID:37673853 | DOI:10.1007/s43440-023-00523-y (Source: Pharmacological Reports)
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Klaudia Brodaczewska Aleksandra Majewska Aleksandra Filipiak-Duliban Claudine Kieda Source Type: research
Modulatory role of vitamins A, B3, C, D, and E on skin health, immunity, microbiome, and diseases
Pharmacol Rep. 2023 Sep 6. doi: 10.1007/s43440-023-00520-1. Online ahead of print.ABSTRACTDisruption of the skin barrier and immunity has been associated with several skin diseases, namely atopic dermatitis (AD), psoriasis, and acne. Resident and non-resident immune cells and the barrier system of the skin are integral to innate immunity. Recent advances in understanding skin microbiota have opened the scope of further understanding the various communications between these microbiota and skin immune cells. Vitamins, being one of the important micronutrients, have been reported to exert antioxidant, anti-inflammatory, and a...
Source: Pharmacological Reports - September 6, 2023 Category: Drugs & Pharmacology Authors: Mahika Joshi Priyanka Hiremath Jeena John Niraja Ranadive Krishnadas Nandakumar Jayesh Mudgal Source Type: research
