Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
This article outlines the protective effects of melatonin against fibrosis, including its safety and potential therapeutic effects. The goal of this article is to provide a summary of data accumulated to date and to encourage further experimentation with melatonin and increase its use as an anti-fibrotic agent in clinical settings.PMID:37995089 | DOI:10.1007/s43440-023-00554-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Mohammad Hossein Pourhanifeh Shiva Amiri Mohammad Sheibani Rana Irilouzadian Russel J Reiter Saeed Mehrzadi Source Type: research
Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer
Curr Pharmacol Rep. 2023 Oct;9(5):261-274. doi: 10.1007/s40495-023-00333-z. Epub 2023 Sep 19.ABSTRACTPURPOSE OF REVIEW: Castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to androgen deprivation therapy and anti-androgens. Here, we review the emerging role of Wnt signaling in therapeutic resistance of CRPC.RECENT FINDINGS: Convincing evidence have accumulated that Wnt signaling is aberrantly activated through genomic alterations and autocrine and paracrine augmentations. Wnt signaling plays a critical role in a subset of CRPC and in resistance to anti-...
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Chandra Kishore Xiaolin Zi Source Type: research
Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
This article outlines the protective effects of melatonin against fibrosis, including its safety and potential therapeutic effects. The goal of this article is to provide a summary of data accumulated to date and to encourage further experimentation with melatonin and increase its use as an anti-fibrotic agent in clinical settings.PMID:37995089 | DOI:10.1007/s43440-023-00554-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Mohammad Hossein Pourhanifeh Shiva Amiri Mohammad Sheibani Rana Irilouzadian Russel J Reiter Saeed Mehrzadi Source Type: research
Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer
Curr Pharmacol Rep. 2023 Oct;9(5):261-274. doi: 10.1007/s40495-023-00333-z. Epub 2023 Sep 19.ABSTRACTPURPOSE OF REVIEW: Castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to androgen deprivation therapy and anti-androgens. Here, we review the emerging role of Wnt signaling in therapeutic resistance of CRPC.RECENT FINDINGS: Convincing evidence have accumulated that Wnt signaling is aberrantly activated through genomic alterations and autocrine and paracrine augmentations. Wnt signaling plays a critical role in a subset of CRPC and in resistance to anti-...
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Chandra Kishore Xiaolin Zi Source Type: research
Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
This article outlines the protective effects of melatonin against fibrosis, including its safety and potential therapeutic effects. The goal of this article is to provide a summary of data accumulated to date and to encourage further experimentation with melatonin and increase its use as an anti-fibrotic agent in clinical settings.PMID:37995089 | DOI:10.1007/s43440-023-00554-5 (Source: Pharmacological Reports)
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Azam Hosseinzadeh Mohammad Hossein Pourhanifeh Shiva Amiri Mohammad Sheibani Rana Irilouzadian Russel J Reiter Saeed Mehrzadi Source Type: research
Wnt Signaling and Therapeutic Resistance in Castration-Resistant Prostate Cancer
Curr Pharmacol Rep. 2023 Oct;9(5):261-274. doi: 10.1007/s40495-023-00333-z. Epub 2023 Sep 19.ABSTRACTPURPOSE OF REVIEW: Castration-resistant prostate cancer (CRPC) is a lethal form of prostate cancer (PCa) due to the development of resistance to androgen deprivation therapy and anti-androgens. Here, we review the emerging role of Wnt signaling in therapeutic resistance of CRPC.RECENT FINDINGS: Convincing evidence have accumulated that Wnt signaling is aberrantly activated through genomic alterations and autocrine and paracrine augmentations. Wnt signaling plays a critical role in a subset of CRPC and in resistance to anti-...
Source: Pharmacological Reports - November 23, 2023 Category: Drugs & Pharmacology Authors: Chandra Kishore Xiaolin Zi Source Type: research
The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14;146:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double t...
Source: Pharmacological Reports - November 16, 2023 Category: Drugs & Pharmacology Authors: Michael DeVito Bas Bokkers Majorie B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthe Source Type: research
The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14;146:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double t...
Source: Pharmacological Reports - November 16, 2023 Category: Drugs & Pharmacology Authors: Michael DeVito Bas Bokkers Majorie B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthe Source Type: research
The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double the n...
Source: Pharmacological Reports - November 16, 2023 Category: Drugs & Pharmacology Authors: Michael DeVito Bas Bokkers M B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthew W Wh Source Type: research
The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double the n...
Source: Pharmacological Reports - November 16, 2023 Category: Drugs & Pharmacology Authors: Michael DeVito Bas Bokkers M B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthew W Wh Source Type: research
The 2022 world health organization reevaluation of human and mammalian toxic equivalency factors for polychlorinated dioxins, dibenzofurans and biphenyls
Regul Toxicol Pharmacol. 2023 Nov 14:105525. doi: 10.1016/j.yrtph.2023.105525. Online ahead of print.ABSTRACTIn October 2022, the World Health Organization (WHO) convened an expert panel in Lisbon, Portugal in which the 2005 WHO TEFs for chlorinated dioxin-like compounds were reevaluated. In contrast to earlier panels that employed expert judgement and consensus-based assignment of TEF values, the present effort employed an update to the 2006 REP database, a consensus-based weighting scheme, a Bayesian dose response modeling and meta-analysis to derive "Best-Estimate" TEFs. The updated database contains almost double the n...
Source: Pharmacological Reports - November 16, 2023 Category: Drugs & Pharmacology Authors: Michael DeVito Bas Bokkers M B M van Duursen Karin van Ede Mark Feeley Elsa Antunes Fernandes G áspár Laurie Haws Sean Kennedy Richard E Peterson Ron Hoogenboom Keiko Nohara Kim Petersen Cynthia Rider Martin Rose Stephen Safe Dieter Schrenk Matthew W Wh Source Type: research
The possible place for psychedelics in pharmacotherapy of mental disorders
Pharmacol Rep. 2023 Nov 7. doi: 10.1007/s43440-023-00550-9. Online ahead of print.ABSTRACTSince its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the therapeutic response and numerous adverse effects. Thus, the scope of contemporary pharmacological research shifts from drugs affecting the serotoni...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Adam Wojtas Source Type: research
Can research on entactogens contribute to a deeper understanding of human sexuality?
This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolac...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Justyna Holka-Pokorska Source Type: research
The possible place for psychedelics in pharmacotherapy of mental disorders
Pharmacol Rep. 2023 Nov 7. doi: 10.1007/s43440-023-00550-9. Online ahead of print.ABSTRACTSince its emergence in the 1960s, the serotonergic theory of depression bore fruit in the discovery of a plethora of antidepressant drugs affecting the lives of millions of patients. While crucial in the history of drug development, recent studies undermine the effectiveness of currently used antidepressant drugs in comparison to placebo, emphasizing the long time it takes to initiate the therapeutic response and numerous adverse effects. Thus, the scope of contemporary pharmacological research shifts from drugs affecting the serotoni...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Adam Wojtas Source Type: research
Can research on entactogens contribute to a deeper understanding of human sexuality?
This study aims to analyze current and planned research on the psychophysiological effects of entactogens on human sexuality. With their prosocial potential, the pharmacokinetic and neuroendocrine effects of entactogens may recreate the subjective experience of emotional intimacy, the initiation of intimate relationships, or even feelings of 'falling in love' with previously neutral individuals while under the influence of entactogens. This includes MDMA-induced sexual arousal-like effects observed through subjective behavioral perceptions of desire and arousal and specific physiological markers such as oxytocin and prolac...
Source: Pharmacological Reports - November 7, 2023 Category: Drugs & Pharmacology Authors: Justyna Holka-Pokorska Source Type: research
