Impact of intensified chemotherapy in metastatic pancreatic ductal adenocarcinoma (PDAC) in clinical routine in Europe
Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis. Gemcitabine is the standard chemotherapy for patients with metastatic pancreatic adenocarcinoma (MPA). Randomized clinical trials evaluating intensified chemotherapies including FOLFIRINOX and nab-paclitaxel plus gemcitabine (NAB+GEM) have shown improvement in survival. Here, we have evaluated the efficacy of intensified chemotherapy versus gemcitabine monotherapy in real-life settings across Europe. (Source: Pancreatology)
Source: Pancreatology - October 15, 2018 Category: Gastroenterology Authors: Muhammad Ahsan Javed, Georg Beyer, Nha Le, Alessio Vinci, Helen Wong, Daniel Palmer, Robert D. Morgan, Angela Lamarca, Richard A. Hubner, Juan W. Valle, Salma Alam, Sumsur Chowdhury, Yuk Ting Ma, Livia Archibugi, Gabriele Capurso, Patrick Maisonneuve, Alb Source Type: research
Characterization of long-term prognosis in acute pancreatitis: An explorative analysis
Severity classification systems of acute pancreatitis (AP) assess inpatient morbidity and mortality without predicting outpatient course of AP. To provide appropriate outpatient care, determinants of long-term prognosis must also be identified. The aim of this study was to define clinical groups that carry long-term prognostic significance in AP. (Source: Pancreatology)
Source: Pancreatology - October 8, 2018 Category: Gastroenterology Authors: Mohannad Abou Saleh, Dharani Guttikonda, Vijit Chouhan, Ashwinee Natu, Michael Enzerra, Raj Paspulati, David Ngendahimana, Bayan Alsuleiman, Lorna Kang, Emad Mansoor, Brooke Glessing, Amitabh Chak, Tyler Stevens, Peter J. Lee Source Type: research
From the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis
In collaboration with United European Gastroenterology, the working group on ‘Harmonizing diagnosis and treatment of chronic pancreatitis across Europe’ (HaPanEU) developed European guidelines for the management of chronic pancreatitis using an evidence-based approach. (Source: Pancreatology)
Source: Pancreatology - October 6, 2018 Category: Gastroenterology Authors: J. Enrique Dominguez-Munoz, Asbj ørn M. Drewes, Björn Lindkvist, Nils Ewald, László Czakó, Jonas Rosendahl, J. Matthias Löhr, HaPanEU/UEG Working Group Source Type: research
Gene expression analysis of embryonic pancreas development master regulators and terminal cell fate markers in resected pancreatic cancer: A correlation with clinical outcome
Despite the recent introduction of new drugs and the development of innovative multi-target treatments, the prognosis of pancreatic ductal adenocarcinoma (PDAC) remains very poor. Even when PDAC is resectable, the rate of local or widespread disease recurrence remains particularly high. Currently, reliable prognostic biomarkers of recurrence are lacking. We decided to explore the potential usefulness of pancreatic developmental regulators as biomarkers of PDAC relapse. (Source: Pancreatology)
Source: Pancreatology - October 4, 2018 Category: Gastroenterology Authors: Erica Dugnani, Valeria Sordi, Silvia Pellegrini, Raniero Chimienti, Ilaria Marzinotto, Valentina Pasquale, Daniela Liberati, Gianpaolo Balzano, Claudio Doglioni, Michele Reni, Alessandra Gandolfi, Massimo Falconi, Vito Lampasona, Lorenzo Piemonti Source Type: research
Acute pancreatitis: Trends in outcomes and the role of acute kidney injury in mortality- A propensity-matched analysis
To assess national trends of AP (acute pancreatitis) admissions, outcomes, prevalence of AKI (acute kidney injury) in AP, and impact of AKI on inpatient mortality. (Source: Pancreatology)
Source: Pancreatology - October 4, 2018 Category: Gastroenterology Authors: Kalpit Devani, Paris Charilaou, Dhruvil Radadiya, Bhaumik Brahmbhatt, Mark Young, Chakradhar Reddy Source Type: research
Organotypic slice cultures of pancreatic ductal adenocarcinoma preserve the tumor microenvironment and provide a platform for drug response
/Objective: The conventional models currently used to evaluate various anti-tumor therapeutic agents are not sufficient for representing human pancreatic ductal adenocarcinoma (PDA), which has a unique tumor microenvironment. We aimed to produce an organotypic slice culture model from human PDA that resembles the in vivo situation and to evaluate the responses of PDA slices to established cytotoxic drugs. (Source: Pancreatology)
Source: Pancreatology - October 3, 2018 Category: Gastroenterology Authors: Chae Yoon Lim, Jae Hyuck Chang, Won Sun Lee, Kang Min Lee, Young Chul Yoon, Jeana Kim, Il Young Park Source Type: research
Higher notch expression implies poor survival in pancreatic ductal adenocarcinoma: A systematic review and meta-analysis
At present, pancreatic ductal adenocarcinoma (PDAC) is a fetal disease lack of effective prognostic and therapeutic methods resulting in high mortality. The Notch signaling has been demonstrated being up- or down-regulated in many cancers, but the effects in pancreatic ductal adenocarcinoma are still controversial. Moreover, the available cases in an individual study are of small samples. Therefore, it is essential to define the effect of Notch signaling in pancreatic ductal adenocarcinoma with larger samples. (Source: Pancreatology)
Source: Pancreatology - October 1, 2018 Category: Gastroenterology Authors: Jianbin Ye, Junjie Wen, Yunshan Ning, Yan Li Source Type: research
Early removal of metal stents in walled off pancreatic necrosis
Endoscopic transmural drainage is the preferred drainage route for walled off necrosis (WON) with larger diameter transmural tract dilatation and placement of multiple plastic stents being advocated to achieve effective drainage of solid necrotic material [1]. Development of dedicated fully covered large diameter metal stents made the management of WON with significant solid debris easier. These stents are easy to deploy with high rate technical success. Also, direct endoscopic necrosectomy (DEN) can be easily performed through the large calibre stent [2]. (Source: Pancreatology)
Source: Pancreatology - October 1, 2018 Category: Gastroenterology Authors: Surinder Singh Rana, Ravi Sharma, Rajesh Gupta Source Type: research
Systemic chemotherapy in combination with liver-directed therapy improves survival in patients with pancreatic adenocarcinoma and synchronous liver metastases
We investigated whether the combination of systemic chemotherapy (SCT) and liver-directed therapy (LDT) was superior to chemotherapy alone for patients with pancreatic adenocarcinoma and synchronous liver metastases (PACLM). (Source: Pancreatology)
Source: Pancreatology - September 29, 2018 Category: Gastroenterology Authors: Huaqiang Ouyang, Weidong Ma, Ti Zhang, Fang Liu, Lujun Zhao, Minghui Fang, Manman Quan, Zhanyu Pan Source Type: research
Diagnosis and management of pancreatic cancer in adults: A summary of guidelines from the UK National Institute for Health and Care Excellence
To enable standardisation of care of pancreatic cancer patients and facilitate improvement in outcome, the United Kingdom's National Institute for Health and Care Excellence (NICE) developed a clinical guideline for the diagnosis and management of pancreatic cancer in adults. Systematic literature searches, systematic review and meta-analyses were undertaken. Recommendations were drafted on the basis of the group's interpretation of the best available evidence of clinical and cost effectiveness. (Source: Pancreatology)
Source: Pancreatology - September 28, 2018 Category: Gastroenterology Authors: Derek O'Reilly, Linyun Fou, Elise Hasler, James Hawkins, Susan O'Connell, Ferruccio Pelone, Mark Callaway, Fiona Campbell, Margred Capel, Richard Charnley, Pippa Corrie, Dawn Elliot, Lesley Goodburn, Anna Jewell, Suzanne Joharchi, Laura McGeeney, Somnath Source Type: research
Relationship between somatostatin and interleukin-6: A cross-sectional study in patients with acute pancreatitis
The aim of the analysis is to determine dynamic changes in somatostatin (SS) and interleukin-6 (IL-6) concentrations during in acute pancreatitis (AP). (Source: Pancreatology)
Source: Pancreatology - September 28, 2018 Category: Gastroenterology Authors: Mariola Sliwinska-Mosson, Grzegorz Marek, Zygmunt Grzebieniak, Halina Milnerowicz Source Type: research
Rationale and feasibility of mucin expression profiling by qRT-PCR as diagnostic biomarkers in cytology specimens of pancreatic cancer
Aberrantly expressed mucin glycoproteins (MUC) play important roles in pancreatic ductal adenocarcinoma (PDAC), yet their use as a diagnostic aid in fine-needle aspiration biopsy (FNAB) is poorly documented. The aim of this study was to investigate the rationale and feasibility of mucin (MUC1, MUC2, MUC3, MUC4, MUC5AC, and MUC6) expression profiling by RT-PCR for diagnostic applications in cytology. (Source: Pancreatology)
Source: Pancreatology - September 27, 2018 Category: Gastroenterology Authors: Milosz Wiktorowicz, Damian Mlynarski, Radoslaw Pach, Romana Tomaszewska, Jan Kulig, Piotr Richter, Marek Sierzega Source Type: research
Impact of preoperative sarcopenia on postoperative outcomes following pancreatic resection: A systematic review and meta-analysis
Morphometric analysis of sarcopenia has garnered interest due to its putative role in predicting outcomes following surgery for a variety of pathologies, including resection for pancreatic disease. However, there are no standard recommendations on whether sarcopenia is a clinically relevant predictor of outcomes in this setting. The aim of this study was to review the prognostic impact of preoperatively diagnosed sarcopenia on postoperative outcomes following pancreatic resection. (Source: Pancreatology)
Source: Pancreatology - September 27, 2018 Category: Gastroenterology Authors: Chathura BB. Ratnayake, Benjamin PT. Loveday, Shailesh V. Shrikhande, John A. Windsor, Sanjay Pandanaboyana Source Type: research
Artificial neural network algorithm model as powerful tool to predict acute lung injury following to severe acute pancreatitis
The aim of this study is to predict the risk of severe acute pancreatitis (SAP) associated with acute lung injury (ALI) by artificial neural networks (ANNs) model. (Source: Pancreatology)
Source: Pancreatology - September 26, 2018 Category: Gastroenterology Authors: Yang Fei, Kun Gao, Wei-qin Li Source Type: research
Management of pregnancy-associated pancreatic cystic tumors: Review of the literature and results of a Pancreas Club Inc. Survey
Management of patients with pregnancy-associated cyst pancreatic cystic tumors (PA-PCT) is complicated by lack of large series. (Source: Pancreatology)
Source: Pancreatology - September 26, 2018 Category: Gastroenterology Authors: Sara Iacopi, Carlo Lombardo, Francesca Menonna, Salvatore Mazzeo, Davide Caramella, Gabriella Amorese, Fabio Vistoli, Ugo Boggi Source Type: research
