Predicting Motor Sequence Learning in Individuals With Chronic Stroke
Conclusion. Nonlinear information extracted from multiple time points across practice, specifically the rate of motor skill acquisition during practice, relates strongly with changes in motor behavior at the retention test following practice and could be used to predict optimal doses of practice on an individual basis. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Wadden, K. P., Asis, K. D., Mang, C. S., Neva, J. L., Peters, S., Lakhani, B., Boyd, L. A. Tags: Original Research Articles Source Type: research

Small-World Characteristics of Cortical Connectivity Changes in Acute Stroke
Conclusions. After an acute stroke, brain cortex rearranges its network connections diffusely, in a frequency-dependent modality probably in order to face the new anatomical and functional frame. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Caliandro, P., Vecchio, F., Miraglia, F., Reale, G., Della Marca, G., La Torre, G., Lacidogna, G., Iacovelli, C., Padua, L., Bramanti, P., Rossini, P. M. Tags: Original Research Articles Source Type: research

Constraint-Induced Aphasia Therapy in the Acute Stage: What Is the Key Factor for Efficacy? A Randomized Controlled Study
Conclusion. It was found that 14 hours of aphasia therapy administered within 2 weeks as individual therapy, focusing on individual deficits, combined with group sessions has proven to be most efficient. This approach yielded the same outcome as 30 hours of group therapy, either in the form of CIAT or group therapy without constraints. SLT in an intensive treatment schedule is feasible and was well tolerated in the acute stage after stroke. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Woldag, H., Voigt, N., Bley, M., Hummelsheim, H. Tags: Original Research Articles Source Type: research

Estimated Prestroke Peak VO2 Is Related to Circulating IGF-1 Levels During Acute Stroke
Conclusions. Improving aerobic fitness prior to stroke may be beneficial by increasing baseline IGF-1 levels. These results set the groundwork for future clinical trials to determine whether high IGF-1 and aerobic fitness are beneficial to stroke recovery by providing neuroprotection and improving function. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Mattlage, A. E., Rippee, M. A., Abraham, M. G., Sandt, J., Billinger, S. A. Tags: Original Research Articles Source Type: research

Electroencephalography-Derived Sensory and Motor Network Topology in Multiple Sclerosis Fatigue
People with multiple sclerosis (MS) frequently complain of excessive fatigue, which is the most disabling symptom for half of them. While the few drugs used to treat MS fatigue are of limited utility, we recently observed the efficacy of a personalized neuromodulation treatment. Here, we aim at strengthening knowledge of the brain network changes that occur when MS fatigue increases, using graph theory. We collected electroencephalographic (EEG; 23 or 64 channels) data in resting state with eyes open in 27 relapsing-remitting (RR) patients with mild MS (EDSS ≤2), suffering a wide range of fatigue as scored by the modifi...
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Vecchio, F., Miraglia, F., Porcaro, C., Cottone, C., Cancelli, A., Rossini, P. M., Tecchio, F. Tags: Original Research Articles Source Type: research

Depression, Type 2 Diabetes, and Poststroke Cognitive Impairment
Conclusions. Diabetes and depressive symptoms were associated cumulatively with poorer cognitive screening outcomes poststroke, particularly deficits in executive function. Having 1 comorbidity doubled the odds of screening for severe cognitive impairment, having both tripled the odds. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Swardfager, W., MacIntosh, B. J. Tags: Original Research Articles Source Type: research

Neuromuscular Impairments Are Associated With Impaired Head and Trunk Stability During Gait in Parkinson Fallers
Conclusions. The results provide evidence of neuromuscular deficits for PD fallers that are independent of medications, symptom severity, and posture and contribute to impaired head, trunk, and pelvis control associated with falls in this population. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Cole, M. H., Naughton, G. A., Silburn, P. A. Tags: Original Research Articles Source Type: research

Relative to Typical Antipsychotic Drugs, Aripiprazole Is a Safer Alternative for Alleviating Behavioral Disturbances After Experimental Brain Trauma
Conclusion. These findings support the hypothesis and endorse ARIP as a safer APD for alleviating behavioral disturbances after TBI. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Phelps, T. I., Bondi, C. O., Mattiola, V. V., Kline, A. E. Tags: Original Research Articles Source Type: research

Can Neurological Biomarkers of Brain Impairment Be Used to Predict Poststroke Motor Recovery? A Systematic Review
Conclusions. There were 3 prevalent methodological limitations: (a) lack of cross-validation, (b) lack of minimal clinically important difference (MCID) for motor outcomes, and (c) small sample size. More high-quality studies are needed to establish which neurological biomarkers are the best predictors of motor recovery after stroke. Finally, the quarter-century old methodological quality tool used here should be updated by inclusion of more contemporary methods and statistical approaches. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - December 10, 2016 Category: Neurology Authors: Kim, B., Winstein, C. Tags: Review Source Type: research

Same Intervention-Different Reorganization: The Impact of Lesion Location on Training-Facilitated Somatosensory Recovery After Stroke
Conclusion. Different patterns of change in activation are evident following touch discrimination training with thalamic/capsular lesions compared with S1/S2 cortical somatosensory lesions, despite common training and similar improvement. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 29, 2016 Category: Neurology Authors: Carey, L. M., Abbott, D. F., Lamp, G., Puce, A., Seitz, R. J., Donnan, G. A. Tags: Clinical Research Articles Source Type: research

Upper-Limb Recovery After Stroke: A Randomized Controlled Trial Comparing EMG-Triggered, Cyclic, and Sensory Electrical Stimulation
Conclusions. All groups exhibited significant improvement of impairment and functional limitation with electrical stimulation therapy applied within 6 months of stroke. Improvements were likely a result of spontaneous recovery. There was no difference based on the type of electrical stimulation that was administered. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 29, 2016 Category: Neurology Authors: Wilson, R. D., Page, S. J., Delahanty, M., Knutson, J. S., Gunzler, D. D., Sheffler, L. R., Chae, J. Tags: Clinical Research Articles Source Type: research

Circadian Melatonin Rhythm Following Traumatic Brain Injury
Conclusions: In patients with TBI, melatonin production was attenuated overnight, and the timing of melatonin secretion was delayed. We suggest that disruption to the circadian regulation of melatonin synthesis is a feature of severe TBI, possibly contributing to the sleep difficulties that are commonly reported in this population. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 29, 2016 Category: Neurology Authors: Grima, N. A., Ponsford, J. L., St. Hilaire, M. A., Mansfield, D., Rajaratnam, S. M. Tags: Clinical Research Articles Source Type: research

The Role of the Frontal Lobe in Complex Walking Among Patients With Parkinsons Disease and Healthy Older Adults: An fNIRS Study
Conclusions. A different pattern of frontal activation during walking was observed between groups. The higher activation during usual walking in patients with PD suggests that the prefrontal cortex plays an important role already during simple walking. However, higher activation relative to baseline during obstacle negotiation and not during DT in the patients with PD demonstrates that prefrontal activation depends on the nature of the task. These findings may have important implications for rehabilitation of gait in patients with PD. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 29, 2016 Category: Neurology Authors: Maidan, I., Nieuwhof, F., Bernad-Elazari, H., Reelick, M. F., Bloem, B. R., Giladi, N., Deutsch, J. E., Hausdorff, J. M., Claassen, J. A. H., Mirelman, A. Tags: Featured articles Clinical Research Articles Source Type: research

Engaging Cervical Spinal Cord Networks to Reenable Volitional Control of Hand Function in Tetraplegic Patients
Conclusions. The present data are sufficient to suggest that hand motor function in individuals with chronic tetraplegia can be improved with cervical cord neuromodulation and thus should be comprehensively explored as a possible clinical intervention. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 29, 2016 Category: Neurology Authors: Lu, D. C., Edgerton, V. R., Modaber, M., AuYong, N., Morikawa, E., Zdunowski, S., Sarino, M. E., Sarrafzadeh, M., Nuwer, M. R., Roy, R. R., Gerasimenko, Y. Tags: Clinical Research Articles Source Type: research

Remodeling of Neuronal Circuits After Reach Training in Chronic Capsular Stroke
Conclusions. Our results suggest that motor recovery and remodeling of neuronal circuits after capsular stroke depend on the magnitude of the capsular lesion and on the presence or absence of reach training. Task-specific training is strongly indicated only when there is incomplete destruction of the capsular fibers. (Source: Neurorehabilitation and Neural Repair)
Source: Neurorehabilitation and Neural Repair - September 29, 2016 Category: Neurology Authors: Cho, J., Kwon, D.-H., Kim, R. G., Song, H., Rosa-Neto, P., Lee, M.-C., Kim, H.-I. Tags: Clinical Research Articles Source Type: research