Meta-analysis of pharmacogenetic interactions in amyotrophic lateral sclerosis clinical trials
(Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Tags: CORRECTIONS Source Type: research
Author response: Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
We appreciate the comments of Machado et al. and Melegari et al. on our guideline, which provided recommendations to reduce brain injury following cardiopulmonary resuscitation (CPR).1 (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Geocadin, R. G., Wijdicks, E., Dubinsky, R. M., Ornato, J. P., Torbey, M. T., Suarez, J. I. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research
Letter Re: Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
We read with interest the article by Geocadin et al.1 and found the conclusion of importance. Over the last 2 years, we observed a group of 32 patients treated with mild therapeutic hypothermia after an out-of-hospital nontraumatic cardiac arrest. When considering the effect of the cardiac arrest on the patients' subsequent outcomes in the short and middle term, a sharp difference between 2 conditions was observed. A cardiac arrest complicated by a not-shockable rhythm and a circulatory instability is usually accompanied by a worsening cerebral edema. These 2 signs, clearly connected to each other, are strong predictors of...
Source: Neurology - November 27, 2017 Category: Neurology Authors: Melegari, G., Barbieri, A., Manenti, A., Bertellini, E., Giuliani, E. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research
Letter Re: Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
The American Academy of Neurology guidelines remarked on required recommendations to reduce brain injury after successful cardiopulmonary resuscitation (CPR).1 Nonetheless, it seems contradictory that prehospital cooling as an adjunct to therapeutic hypothermia (TH) is decidedly ineffectual in further improving neurologic outcome and survival.1 (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Machado, C., Estevez, M., Leisman, G. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research
Editors' Note
: In "Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology," the authors concluded that prehospital cooling did not improve neurologic outcome or survival in patients who subsequently underwent in-hospital therapeutic hypothermia. Drs. Machado et al. comment that studies in animals and of accidental hypothermia have shown a benefit to early hypothermia, and that, intuitively, any neuroprotective intervention should be initiated as soon as possible. (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Alcauskas, M., Galetta, S. Tags: WRITECLICK & amp;reg; EDITOR ' S CHOICE Source Type: research
Radiation-induced spinal nerve root cavernous malformations as a rare cause of radiculopathy
A 48-year-old man with Hodgkin lymphoma presented with insidious painless asymmetric ankle then thigh weakness 16 years after mantle-field radiation. EMG was consistent with a motor lumbosacral polyradiculopathy. CSF had 15 white blood cells/μL, protein 387 mg/dL, and normal glucose. Nodular enhancing lesions were seen on lumbar MRI (figure 1). Caudal root biopsy demonstrated mulberry-shaped vascular abnormalities (figure 2) and thickened endoneurial vessel walls without inflammation. Workup for leptomeningeal carcinomatosis and inflammatory and infectious disease was negative. High-dose steroids produced no clinical im...
Source: Neurology - November 27, 2017 Category: Neurology Authors: Rastogi, K., Klein, C. J., O'Toole, J. E., Jhaveri, M. D., Malik, R. Tags: MRI, All Clinical Neurology, All Neuromuscular Disease, All Oncology, All Spinal Cord NEUROIMAGES Source Type: research
Pyruvate dehydrogenase complex-E2 deficiency causes paroxysmal exercise-induced dyskinesia
We report a patient with intellectual disability and this unique phenotype associated with homozygous missense mutation in the DLAT gene (c.470T>G; p.Val157Gly) that encodes the E2 component of the pyruvate dehydrogenase complex (PDC). This case of PED associated with DLAT mutations broadens the phenotypic spectrum for this ultra-rare condition and widens the range of potentially treatable PEDs. (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Friedman, J., Feigenbaum, A., Chuang, N., Silhavy, J., Gleeson, J. G. Tags: All Movement Disorders, Dystonia CLINICAL/SCIENTIFIC NOTES Source Type: research
Practice guideline: Cervical and ocular vestibular evoked myogenic potential testing: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology
Objective:
To systematically review the evidence and make recommendations with regard to diagnostic utility of cervical and ocular vestibular evoked myogenic potentials (cVEMP and oVEMP, respectively). Four questions were asked: Does cVEMP accurately identify superior canal dehiscence syndrome (SCDS)? Does oVEMP accurately identify SCDS? For suspected vestibular symptoms, does cVEMP/oVEMP accurately identify vestibular dysfunction related to the saccule/utricle? For vestibular symptoms, does cVEMP/oVEMP accurately and substantively aid diagnosis of any specific vestibular disorder besides SCDS?
Methods:
The guideline pane...
Source: Neurology - November 27, 2017 Category: Neurology Authors: Fife, T. D., Colebatch, J. G., Kerber, K. A., Brantberg, K., Strupp, M., Lee, H., Walker, M. F., Ashman, E., Fletcher, J., Callaghan, B., Gloss, D. S. Tags: All Neurotology, Evoked Potentials/Visual, Evoked Potentials/Auditory SPECIAL ARTICLE Source Type: research
Low-dose aspirin and risk of intracranial bleeds: An observational study in UK general practice
Conclusion:
Low-dose aspirin is not associated with an increased risk of any type of ICB and is associated with a significantly decreased risk of SAH when used for ≥1 year. (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Cea Soriano, L., Gaist, D., Soriano-Gabarro, M., Bromley, S., Garcia Rodriguez, L. A. Tags: All Cerebrovascular disease/Stroke, Case control studies, Risk factors in epidemiology ARTICLE Source Type: research
Predicting clinical decline in progressive agrammatic aphasia and apraxia of speech
Conclusions:
Rate of decline of each of the 4 clinical features assessed was associated with different baseline clinical and regional MRI predictors. Our findings could help improve prognostic estimates for these patients. (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Whitwell, J. L., Weigand, S. D., Duffy, J. R., Clark, H. M., Strand, E. A., Machulda, M. M., Spychalla, A. J., Senjem, M. L., Jack, C. R., Josephs, K. A. Tags: Volumetric MRI, Prognosis, Dementia aphasia ARTICLE Source Type: research
Midlife systemic inflammatory markers are associated with late-life brain volume: The ARIC study
Conclusions:
Our prospective findings provide evidence for what may be an early contributory role of systemic inflammation in neurodegeneration and cognitive aging. (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Walker, K. A., Hoogeveen, R. C., Folsom, A. R., Ballantyne, C. M., Knopman, D. S., Windham, B. G., Jack, C. R., Gottesman, R. F. Tags: MRI, All Immunology, All Medical/Systemic disease, Alzheimer's disease, Risk factors in epidemiology ARTICLE Source Type: research
Early weight loss in parkinsonism predicts poor outcomes: Evidence from an incident cohort study
Conclusion:
Weight loss occurs in early parkinsonism and is greater in atypical parkinsonism than in PD. Early weight loss in parkinsonism has prognostic significance, and targeted dietary interventions to prevent it may improve long-term outcomes. (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Cumming, K., Macleod, A. D., Myint, P. K., Counsell, C. E. Tags: Parkinson's disease/Parkinsonism, Prognosis, All epidemiology, Natural history studies (prognosis) ARTICLE Source Type: research
Efficacy and safety of abobotulinumtoxinA in spastic lower limb: Randomized trial and extension
Conclusions:
In chronic hemiparesis, single abobotulinumtoxinA (Dysport Ipsen) administration reduced muscle tone. Repeated administration over a year was well-tolerated and improved walking speed and likelihood of achieving community ambulation.
Clinicaltrial.gov identifiers:
NCT01249404, NCT01251367.
Classification of evidence:
The double-blind phase of this study provides Class I evidence that for adults with chronic spastic hemiparesis, a single abobotulinumtoxinA injection reduces lower extremity muscle tone. (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Gracies, J.-M., Esquenazi, A., Brashear, A., Banach, M., Kocer, S., Jech, R., Khatkova, S., Benetin, J., Vecchio, M., McAllister, P., Ilkowski, J., Ochudlo, S., Catus, F., Grandoulier, A. S., Vilain, C., Picaut, P., On behalf of the International Abobotul Tags: Gait disorders/ataxia, Botulinum toxin, All Clinical trials ARTICLE Source Type: research
High risk of postpartum relapses in neuromyelitis optica spectrum disorder
Conclusions:
The postpartum period is a particularly high-risk time for initial presentation of NMOSD. In contrast to published observations in multiple sclerosis, in neuromyelitis optica, relapse rate during pregnancy was also increased, although to a lesser extent than after delivery. (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Klawiter, E. C., Bove, R., Elsone, L., Alvarez, E., Borisow, N., Cortez, M., Mateen, F., Mealy, M. A., Sorum, J., Mutch, K., Tobyne, S. M., Ruprecht, K., Buckle, G., Levy, M., Wingerchuk, D., Paul, F., Cross, A. H., Jacobs, A., Chitnis, T., Weinshenker, B Tags: Devic's syndrome ARTICLE Source Type: research
Monitoring disease activity in multiple sclerosis using serum neurofilament light protein
Conclusions:
Serum and CSF NFL levels were highly correlated, indicating that blood sampling can replace CSF taps for this particular marker. Disease activity and DMT had similar effects on serum and CSF NFL concentrations. Repeated NFL determinations in peripheral blood for detecting axonal damage may represent new possibilities in MS monitoring. (Source: Neurology)
Source: Neurology - November 27, 2017 Category: Neurology Authors: Novakova, L., Zetterberg, H., Sundström, P., Axelsson, M., Khademi, M., Gunnarsson, M., Malmeström, C., Svenningsson, A., Olsson, T., Piehl, F., Blennow, K., Lycke, J. Tags: Cerebrospinal Fluid, Multiple sclerosis ARTICLE Source Type: research
