Osteoprotegerin is an Early Marker of the Fibrotic Process and of Antifibrotic Treatment Responses in Ex Vivo Lung Fibrosis
ConclusionOPG can already be detected during the early stages of fibrosis development and responds, both in early- and late-stage fibrosis, to treatment with antifibrotic drugs currently on the market for lung fibrosis. Therefore, OPG should be further investigated as a potential biomarker for lung fibrosis and a potential surrogate marker for treatment effect. (Source: Lung)
Source: Lung - April 20, 2024 Category: Respiratory Medicine Source Type: research
Heat-Induced Secretion of Heat Shock Proteins 70 and 90 Does not Affect the Expression of the Glucocorticoid Receptor in Primary Airway Cells in COPD
ConclusionsThe results of this study indicate that primary airway cells from COPD patients respond differently to heat exposure and extracellular HSP70 or HSP90 than cells from asthma patients regarding the expression of GR and this may explain the reduced response to glucocorticoids in patients with COPD.Trial Registration: ISRCTN11017699 (Source: Lung)
Source: Lung - April 19, 2024 Category: Respiratory Medicine Source Type: research
Endobronchial Ultrasound Guided Transbronchial Needle Aspiration and PD-L1 Yields
ConclusionEBUS-TBNA offers high yields for assessing immunotherapy markers like PD-L1, with satisfactory adequacy regardless of NSCLC subtype, lesion size, or location. (Source: Lung)
Source: Lung - April 18, 2024 Category: Respiratory Medicine Source Type: research
Authors ’ Reply to Letter to the Editor Regarding the Article “Genetic Association of Circulating Adipokines with Risk of Idiopathic Pulmonary Fibrosis: a Two-Sample Mendelian Randomization Study”
(Source: Lung)
Source: Lung - April 16, 2024 Category: Respiratory Medicine Source Type: research
Commentary: Genetic Association of Circulating Adipokines with Risk of Idiopathic Pulmonary Fibrosis: A Two‑Sample Mendelian Randomization Study
(Source: Lung)
Source: Lung - April 16, 2024 Category: Respiratory Medicine Source Type: research
Genetic Spectrum and Clinical Characteristics of Patients with Primary Ciliary Dyskinesia: a Belgian Single Center Study
ConclusionThis study suggests a genotype –phenotype correlation for some of the evaluated clinical characteristics of the two most frequently involved genes in this study, namelyDNAH11 andDNAH5. (Source: Lung)
Source: Lung - April 11, 2024 Category: Respiratory Medicine Source Type: research
Dysphagia as a Missing Link Between Post-surgical- and Opioid-Related Pneumonia
ConclusionOropharyngeal swallow is impaired by the partial mu-opioid receptor agonist buprenorphine, most remarkably in the postoperative setting. These findings have implications for the prevention and management of aspiration pneumonia in vulnerable populations. (Source: Lung)
Source: Lung - March 27, 2024 Category: Respiratory Medicine Source Type: research
First Exploration of the Altered Microbial Gut –Lung Axis in the Pathogenesis of Human Refractory Chronic Cough
ConclusionSince differences in both GM and OM of RCC patients have been documented, these findings could provide new information about RCC pathogenesis and also pave the way for the development of novel nutritional or pharmacological interventions for the management of RCC through the restoration of eubiotic gut –lung communication. (Source: Lung)
Source: Lung - March 25, 2024 Category: Respiratory Medicine Source Type: research
Relationship Between Diaphragm Thickness, Thickening Fraction, Dome Excursion, and Respiratory Pressures in Healthy Subjects: An Ultrasound Study
ConclusionIn healthy adults, DE (DB) has a relationship with MIP and MEP. Sex, age, and BMI, but not height, are influencing factors on this relationship. (Source: Lung)
Source: Lung - March 23, 2024 Category: Respiratory Medicine Source Type: research
Outcomes of Extracorporeal Life Support (ECLS) in Acute Severe Asthma: A Narrative Review
ConclusionOur review identified a variation between institutions in the initiation of ECMO and ECCO2R in patients with status asthmaticus and discrepancy in the severity of illness at the time of cannulation. Despite that, mortality in these studies was relatively low with some studies reporting no mortality which could be attributed to selection bias. While ECMO and ECCO2R use in severe asthma patients is associated with complication risks, further studies exploring the use of ECMO and ECCO2R with mechanical ventilation are required to identify patients with favorable risk benefit ratio. (Source: Lung)
Source: Lung - March 21, 2024 Category: Respiratory Medicine Source Type: research
