Authors Response
(Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: Bector, S., Vagianos, K., Suh, M., Duerksen, D. R. Tags: Authors ' Response Source Type: research

Identification of Malnutrition in Critically Ill Patients via the Subjective Global Assessment Tool: More Consideration Needed?
(Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: Lambell, K., King, S., Ridley, E. Tags: Letter to the Editor Source Type: research

Measurement of Mitochondrial Respiration and Motility in Acute Care: Sepsis, Trauma, and Poisoning
Metabolic biomarkers have potentially wider use in disease diagnosis and prognosis as well as in monitoring disease response to treatment. While biomarkers such as interleukins, microRNA, and lactate have been proposed for disease surveillance, there are still conflicting results regarding their clinical utility. Treatment of commonly encountered disease of acute care such as sepsis, trauma, and poisoning often relies on clinical diagnosis and therapy guided by use of surrogate markers of illness severity. The measurement of mitochondrial function, including respiration and motility, may offer superior alternatives to such...
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: Jang, D. H., Greenwood, J. C., Spyres, M. B., Eckmann, D. M. Tags: Techniques and Procedures Source Type: research

Inflammation-Induced Changes in Circulating T-Cell Subsets and Cytokine Production During Human Endotoxemia
Observational clinical studies suggest the initial phase of sepsis may involve impaired cellular immunity. In the present study, we investigated temporal changes in T-cell subsets and T-cell cytokine production during human endotoxemia. Endotoxin (Escherichia coli lipopolysaccharide 4 ng/kg) was administered intravenously in 15 healthy volunteers. Peripheral blood and bronchoalveolar lavage fluid (BALF) were collected at baseline and after 2, 4, 6, 8, and 24 hours for flow cytometry. CD4+CD25+CD127lowFoxp3+ regulatory T cells (Tregs), CD4+CD161+ cells, and activated Human leukocyte antigen, HLA-DR+CD38+ T cells were determ...
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: Ronit, A., Plovsing, R. R., Gaardbo, J. C., Berg, R. M. G., Hartling, H. J., Ullum, H., Andersen, A. B., Madsen, H. O., Moller, K., Nielsen, S. D. Tags: Original Research Source Type: research

Improving Caregivers Perceptions Regarding Patient Goals of Care/End-of-Life Issues for the Multidisciplinary Critical Care Team
Conclusion: We created a novel unit-based multidisciplinary program for improved EOL/GOC approaches in the critical care setting. A similarly formatted program could be adapted by other ICUs. Benefits of such a program include improving caregivers’ perceptions regarding EOL/GOC issues and fostering critical care team growth. (Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: Wessman, B. T., Sona, C., Schallom, M. Tags: Original Research Source Type: research

The Impact and Statistical Analysis of a Multifaceted Anticoagulation Strategy in Children Supported on ECMO: Performance and Pitfalls
Conclusions: A multipronged monitoring regimen slightly increased the amount of time that anticoagulation parameters were within range. Correlations between the HID and the aPTT differed based on anticoagulation protocol, with a positive correlation in the older protocol and no correlation in the new protocol. This may highlight a problem in study design and analysis that requires further examination. Further trials are needed to assess the most useful markers with which anticoagulation protocols for ECMO can be created, adjusted, and evaluated. (Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: Kessel, A. D., Kline, M., Zinger, M., McLaughlin, D., Silver, P., Sweberg, T. M. Tags: Original Research Source Type: research

Insulin and the Brain: A Sweet Relationship With Intensive Care
Conclusion: In this systematic review, we present a close relationship between insulin and the brain, with discernible effects on memory, learning abilities, and motor functions. The potential therapeutic effects extend from acute brain insults such as traumatic brain injury, brain ischemia, and hemorrhage, to chronic neurodegenerative diseases such as Alzheimer and Parkinson disease. An understanding of the wider effects of insulin conveyed in this review will prompt anaesthesiologists and critical care physicians to consider its therapeutic potential and guide future studies. (Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: Bilotta, F., Lauretta, M. P., Tewari, A., Haque, M., Hara, N., Uchino, H., Rosa, G. Tags: Reviews of a Large Clinical Series Source Type: research

Customization of a Severity of Illness Score Using Local Electronic Medical Record Data
Conclusions: Custom models based on ICU-specific data provided better mortality prediction than traditional SAPS scoring using the same predictor variables. Our local data approach demonstrates the value of electronic data capture in the ICU, of secondary uses of EMR data, and of local customization of SOI scoring. (Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: Lee, J., Maslove, D. M. Tags: Reviews of a Large Clinical Series Source Type: research

Antimicrobial Resistance in the Intensive Care Unit: A Focus on Gram-Negative Bacterial Infections
Bacterial infections are a frequent cause of hospitalization, and nosocomial infections are an increasingly common condition, particularly within the acute/critical care setting. Infection control practices and new antimicrobial development have primarily focused on gram-positive bacteria; however, in recent years, the incidence of infections caused by gram-negative bacteria has risen considerably in intensive care units. Infections caused by multidrug-resistant (MDR) gram-negative organisms are associated with high morbidity and mortality, with significant direct and indirect costs resulting from prolonged hospitalization...
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: MacVane, S. H. Tags: Analytic Reviews Source Type: research

Critical Care Management of Cerebral Edema in Brain Tumors
Cerebral edema associated with brain tumors is extremely common and can occur in both primary and metastatic tumors. The edema surrounding brain tumors results from leakage of plasma across the vessel wall into the parenchyma secondary to disruption of the blood–brain barrier. The clinical signs of brain tumor edema depend on the location of the tumor as well as the extent of the edema, which often exceeds the mass effect induced by the tumor itself. Uncontrolled cerebral edema may result in increased intracranial pressure and acute herniation syndromes that can result in permanent neurological dysfunction and potent...
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: Esquenazi, Y., Lo, V. P., Lee, K. Tags: Analytic Reviews Source Type: research

Approach to the Complicated Alcohol Withdrawal Patient
Alcohol withdrawal syndromes are common causes for admission to the intensive care unit. As many as one-fifth of the admitted patients have an alcohol-associated disorder. Identifying the benefit of the -aminobutyric acid (GABA) agonists has shifted toward methods to improve benzodiazepine (BZD) utilization. Literature validating this treatment approach in severe withdrawal, especially in the critical care setting, is limited, and extrapolation to this population may be dangerous. Multiple therapies have been suggested or utilized in the literature including continuous infusion of GABA agonists, ethanol, dexmedetomidine, a...
Source: Journal of Intensive Care Medicine - November 29, 2016 Category: Intensive Care Authors: Ferreira, J. A., Wieruszewski, P. M., Cunningham, D. W., Davidson, K. E., Weisberg, S. F. Tags: Analytic Reviews Source Type: research

Clot Extraction With the FlowTriever Device in Acute Massive Pulmonary Embolism
We report an acute PE case in which treatment options were limited, and a novel device, the FlowTriever (Inari Medical, Irvine, California), was successfully used. This is the first case report of the use of this device that we are aware of. (Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - October 24, 2016 Category: Intensive Care Authors: Weinberg, A. S., Dohad, S., Ramzy, D., Madyoon, H., Tapson, V. F. Tags: Case Report Source Type: research

Postintubation Hypotension in General Anesthesia: A Retrospective Analysis
Conclusions: Development of PIH occurs in 60% of patients undergoing intubation for vascular surgery and was associated with adverse outcomes including extended ICU LOS and postop ventilation requirement. (Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - October 24, 2016 Category: Intensive Care Authors: Green, R. S., Butler, M. B. Tags: Original Research Source Type: research

Identifying High-Risk Children in the Emergency Department
Conclusions: Elevated MPEWS in the ED is associated with increased risk of ward-to-PICU transfer within 24 hours of admission; however, an MPEWS threshold of 7 is not sufficient to identify more than a small proportion of ward-admitted children with subsequent clinical deterioration. (Source: Journal of Intensive Care Medicine)
Source: Journal of Intensive Care Medicine - October 24, 2016 Category: Intensive Care Authors: Nielsen, K. R., Migita, R., Batra, M., Gennaro, J. L. D., Roberts, J. S., Weiss, N. S. Tags: Reviews of a Large Clinical Series Source Type: research

Nosocomial Bloodstream Infections in Patients Receiving Extracorporeal Life Support: Variability in Prevention Practices: A Survey of the Extracorporeal Life Support Organization Members
Nosocomial blood stream infections (BSIs) increase both the morbidity and the mortality of patients receiving extracorporeal life support (ECLS). The aim of this study was to identify common practices for blood stream infection prevention among national Extracorporeal Membrane Oxygenation (ECMO) programs. An electronic survey that comprised of a 16-item questionnaire was sent out to all ECMO program directors and coordinators within the United States that are part of the Extracorporeal Life Support Organization (ELSO) registry. A total of 152 institutions in 40 states were surveyed, with 85 (55%) responses. One-quarter of ...
Source: Journal of Intensive Care Medicine - October 24, 2016 Category: Intensive Care Authors: Glater-Welt, L. B., Schneider, J. B., Zinger, M. M., Rosen, L., Sweberg, T. M. Tags: Reviews of a Large Clinical Series Source Type: research