HMGB1 promotes neutrophil PD-L1 expression through TLR2 and mediates T cell apoptosis leading to immunosuppression in sepsis
Int Immunopharmacol. 2024 Apr 21;133:112130. doi: 10.1016/j.intimp.2024.112130. Online ahead of print.ABSTRACTNeutrophils and T lymphocytes are closely related to occurrence of immunosuppression in sepsis. Studies have shown that neutrophil apoptosis decreases and T lymphocyte apoptosis increases in sepsis immunosuppression, but the specific mechanism involved remains unclear. In the present study, we found Toll-like Receptor 2 (TLR2) and programmed death-ligand 1 (PD-L1) were significantly activated in bone marrow neutrophils of wild-type mice after LPS treatment and that they were attenuated by treatment with C29, an inh...
Source: International Immunopharmacology - April 22, 2024 Category: Allergy & Immunology Authors: Jinlian Liu Ke Song Bingqi Lin Zhenfeng Chen Zirui Zuo Yixing Fang Qi He Xiaodan Yao Zhifeng Liu Qiaobing Huang Xiaohua Guo Source Type: research
Inhibition of Golgi stress alleviates sepsis-induced cardiomyopathy by reducing inflammation and apoptosis
CONCLUSION: Golgi stress mediates SIC, and the inhibition of Golgi stress can improve SIC by inhibiting apoptosis and inflammation.PMID:38648713 | DOI:10.1016/j.intimp.2024.112103 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 22, 2024 Category: Allergy & Immunology Authors: Shuqi Meng Jianfeng Liu Zhiwei Wang Yan Fan Shuaijie Pei Enquan Wang Yu Song Yan Cui Keliang Xie Source Type: research
Intravenous immunoglobulin alleviates Japanese encephalitis virus-induced peripheral neuropathy by inhibiting the ASM/ceramide pathway
In this study, we found that high doses of intravenous immunoglobulin, a function inhibitor of acid sphingomyelinase (FIASMA), inhibited acid sphingomyelinase (ASM) and ceramide activity in the serum and sciatic nerve of JEV-infected rats, reduced disease severity, reversed electrophysiological and histological abnormalities, significantly reduced circulating proinflammatory cytokine levels, inhibited Th1 and Th17 cell proliferation, and suppressed the infiltration of inflammatory CD4 + cells into the sciatic nerve. It also maintained the peripheral nerve-blood barrier without causing severe clinical side effects. In terms...
Source: International Immunopharmacology - April 22, 2024 Category: Allergy & Immunology Authors: Na Zhang Guowei Wang Liping Yang Jinyuan Zhang YanPing Yuan Lijun Ma Zhenhai Wang Source Type: research
A potential virulence factor: Brucella flagellin FliK does not affect the main biological properties but inhibits the inflammatory response in RAW264.7 cells
In conclusion, our study suggests that Brucella FliK may act as a virulence factor involved in the regulation of Brucella pathogenicity and modulation of the host immune response.PMID:38648715 | DOI:10.1016/j.intimp.2024.112119 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 22, 2024 Category: Allergy & Immunology Authors: Yunyi Zhai Jiaoyang Fang Weifang Zheng Mingyue Hao Jialu Chen XiaoFang Liu MengYu Zhang Lin Qi Dong Zhou Wei Liu Yaping Jin Aihua Wang Source Type: research
Potential immune-related therapeutic mechanisms of multiple traditional Chinese medicines on type 2 diabetic nephropathy based on bioinformatics, network pharmacology and molecular docking
CONCLUSION: The potential hub biomarkers and immunotherapy targets associated with immune cells of T2DN comprise CXCR1, CXCR2, and FOS. Furthermore, kaempferol, quercetin, and luteolin demonstrate potential immunomodulatory effects in modulating T2DN through the regulation of CXCR1, CXCR2, and FOS expression.PMID:38648716 | DOI:10.1016/j.intimp.2024.112044 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 22, 2024 Category: Allergy & Immunology Authors: Mingzheng Han Jiale Li Yijin Wu Zhaoxin Tang Source Type: research
Tranilast alleviates visceral hypersensitivity and colonic hyperpermeability by suppressing NLRP3 inflammasome activation in irritable bowel syndrome rat models
In conclusion, tranilast improved visceral pain and colonic barrier by suppression of the NLRP3 inflammasome in IBS rat models. Tranilast may be useful for IBS treating.PMID:38643709 | DOI:10.1016/j.intimp.2024.112099 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 21, 2024 Category: Allergy & Immunology Authors: Tsukasa Nozu Hideyuki Arie Saori Miyagishi Masatomo Ishioh Kaoru Takakusaki Toshikatsu Okumura Source Type: research
EGCG suppresses PD-1 expression of T cells via inhibiting NF- κB phosphorylation and nuclear translocation
Int Immunopharmacol. 2024 Apr 20;133:112069. doi: 10.1016/j.intimp.2024.112069. Online ahead of print.ABSTRACTEpigallocatechin-3-gallate (EGCG) is an important tea polyphenol with anti-tumor potential. Our previous studies revealed that EGCG was a promising immune checkpoint inhibitor (ICI) as it could downregulate expression of programmed cell death 1 ligand 1 (PD-L1) in tumor cells, thereby resulting tumor killing effect. In particular, EGCG can effectively avoid the inflammatory storm caused by anti-tumor therapy, which is a healthy green capacity absent from many ICIs. However, the relationship between EGCG and program...
Source: International Immunopharmacology - April 21, 2024 Category: Allergy & Immunology Authors: Zhong-Da Li Fangfang Liu Yanqiao Zeng Yingnan Liu Wenhe Luo Feng Yuan Su Li Qi Li Jiaxin Chen Mayumi Fujita Guofang Zhang Yang Li Source Type: research
The protective effect of Macrostemonoside T from Allium macrostemon Bunge against Isoproterenol-Induced myocardial injury via the PI3K/Akt/mTOR signaling pathway
This study established an ISO-induced MI model in rats and assessed H9c2 cytotoxicity to examine MST's impact on MI. Various assays, including histopathological staining, TUNEL staining, immunohistochemical staining, DCFH-DA staining, JC-1 staining, ELISA technique, and Western blot (WB), were utilized to explore the potential molecular mechanisms of MI protection. In vivo experiments demonstrated that ISO caused myocardial fiber disorders, elevated cardiac enzyme levels, and apoptosis. However, pretreatment with MST significantly mitigated these detrimental changes. In vitro experiments revealed that MST boosted antioxida...
Source: International Immunopharmacology - April 20, 2024 Category: Allergy & Immunology Authors: Jianfa Wu Ying Cui Weixing Ding Jing Zhang Lulu Wang Source Type: research
Berberine alleviates neuroinflammation by downregulating NFkB κκNF/LCN2 pathway in sepsis-associated encephalopathy: Network pharmacology, bioinformatics, and experimental validation
CONCLUSION: Overall, Berberine may exert anti-inflammatory effects through multi-ingredients, multi-targets and multi-pathways to partially rescue neuronal death and alleviate SAE.PMID:38640713 | DOI:10.1016/j.intimp.2024.112036 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Hailong Gong Yun Xia Guoqing Jing Min Yuan Huimin Zhou Die Wu Jing Zuo Chuntian Lei Delida Aidebaike Xiaojing Wu Xuemin Song Source Type: research
Prospects and challenges of CAR-T in the treatment of ovarian cancer
Int Immunopharmacol. 2024 Apr 18;133:112112. doi: 10.1016/j.intimp.2024.112112. Online ahead of print.ABSTRACTOvarian cancer ranks as the seventh most prevalent cancer among women and is considered the most lethal gynecological malignancy on a global scale. The absence of reliable screening techniques, coupled with the insidious onset of nonspecific symptoms, often results in a delayed diagnosis, typically at an advanced stage characterized by peritoneal involvement. Management of advanced tumors typically involves a combination of chemotherapy and cytoreductive surgery. However, the therapeutic arsenal for ovarian cancer ...
Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Biqing Chen Jiaqi Liu Source Type: research
A single chain variable fragment antibody (Tn 64) cognate to fibronectin type III repeats promotes corneal wound healing by inhibiting fibrosis
We examined corneal epithelial as well as stromal wound healing through Tn64 binding to Tn fn 3-5, using a human corneal epithelial cell (HCEC) line, primary cultures of human corneal fibroblasts (HCFs), and an ex-vivo corneal organ culture model. Tn64 enhanced proliferation and adhesion of corneal epithelial cells, while inhibiting the migration of corneal fibroblasts and myofibroblasts. Tn64 appears to attenuate inflammation through downregulation of TNF-α, prevent corneal fibrosis by limiting fibronectin polymerization, and promote regeneration of corneal epithelia and stroma, suggesting that it could be developed as a...
Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Ashu Shukla Vyshak Suresh Parul Chawla Gupta Maryada Sharma Uma Nahar Saikia Jagat Ram Manni Luthra-Guptasarma Source Type: research
Single-cell transcriptome profiling reveals cell type-specific variation and development in HLA expression of human skin
Int Immunopharmacol. 2024 Apr 18;133:112070. doi: 10.1016/j.intimp.2024.112070. Online ahead of print.ABSTRACTSkin, the largest organ of body, is a highly immunogenic tissue with a diverse collection of immune cells. Highly polymorphic human leukocyte antigen (HLA) molecules have a central role in coordinating immune responses as recognition molecules. Nevertheless, HLA gene expression patterns among diverse cell types within a specific organ, like the skin, have yet to be thoroughly investigated, with stromal cells attracting much less attention than immune cells. To illustrate HLA expression profiles across different cel...
Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Yumiao Lin Xinxin Li Jingxian Fang Qinglan Zeng Danling Cheng Gaofeng Wang Runlu Shi Yilin Luo Yihe Ma Miaomiao Li Xiang Tang Xusheng Wang Ruiyun Tian Source Type: research
Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence
In conclusion, This study suggest that genkwanin inhibits inflammation in nucleus pulposus cells, promotes extracellular matrix remodeling, suppresses cellular senescence and apoptosis, through the ITGA2/PI3K/AKT, NF-κB and MAPK signaling pathways. These findings indicate that genkwanin may be a promising therapeutic candidate for IVDD.PMID:38640717 | DOI:10.1016/j.intimp.2024.112101 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Mengwei Li Xiaojun Yu Xin Chen Yongqiao Jiang Yunqian Zeng Ranyue Ren Mingbo Nie Ziyang Zhang Yuan Bao Hao Kang Source Type: research
Influence of genetic polymorphisms on imatinib concentration and therapeutic response in patients with chronic-phase chronic myeloid leukemia
CONCLUSIONS: Genotyping of ABCB1, ABCG2, and CYP3A5 genes may be considered in the management of patients with CML to tailor therapy and optimize clinical outcomes.PMID:38640718 | DOI:10.1016/j.intimp.2024.112090 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Fang Cheng Zheng Cui Qiang Li Shi Chen Weiming Li Yu Zhang Source Type: research
Corrigendum to "Effects of platelet rich plasma on experimentally induced diabetic heart injury" [Int. Immunopharm. 96 (2021) 107814]
Int Immunopharmacol. 2024 Apr 18:112089. doi: 10.1016/j.intimp.2024.112089. Online ahead of print.NO ABSTRACTPMID:38641472 | DOI:10.1016/j.intimp.2024.112089 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 19, 2024 Category: Allergy & Immunology Authors: Sara Mohamed Naguib Abdel Hafez Nagwa M Zenhom Heba A Abdel-Hamid Source Type: research
