IL-1 β Antagonist Receptor Peptide Associated with Photobiomodulation Accelerates Diabetic Wound Tissue Repair
This study aimed to investigate the effect of an IL-1β inhibitor molecule associated with PBM irradiation in a model of epithelial injury in diabetic mice. After the induction of the DM model with streptozotocin (STZ), the skin lesion model was implemented through surgical excision. Sixty C57BL/6 mice divided into five experiment al groups (n = 12) were used: excisional wound (EW), DM + EW, DM + EW + DAP 1–2 (inhibitor peptide), DM + EW + PBM, and DM + EW + PBM + DAP 1–2. Treatment started 12 h after wound induction and was performed daily for 5 days. Twenty-four hours after the la...
Source: Inflammation - January 18, 2024 Category: Allergy & Immunology Source Type: research

Urokinase Plasminogen Activator Receptor: An Important Focal Player in Chronic Subdural Hematoma?
AbstractChronic subdural hematoma (CSDH) development involves inflammatory, angiogenetic, and fibrinolytic mechanisms, several components of which are now unraveled through intensive research. The urokinase plasminogen activator receptor (uPAR) is part of the plasminogen activator system and possesses inflammatory, angiogenetic, and fibrinolytic capabilities. As a first, this study aims to identify uPAR in the hematoma fluid, hematoma membrane, dura mater, and systemic blood from patients with CSDH and, if present, to investigate if the uPAR level at the time of surgery may be a predictor for later developing recurrent CSD...
Source: Inflammation - January 18, 2024 Category: Allergy & Immunology Source Type: research

Auraptene Mitigates Colitis Induced by Dextran Sulfate Sodium in Mice by Regulating Specific Intestinal Flora and Repairing the Intestinal Barrier
In conclusion, AUT mitigates DSS-induced colitis by maintaining the integrity of the intestinal barrier and modulating the levels of the intestinal microbial species.Graphical AbstractTOC Graphic. Diagram summarizing the study findings. Auraptene mitigates dextran sulfate sodium-induced colitis in mice by regulating specific intestinal flora and repairing the intestinal barrier. (Source: Inflammation)
Source: Inflammation - January 18, 2024 Category: Allergy & Immunology Source Type: research

METTL3 Modulates TXNIP Expression to Affect the Activation of NLRP3 Inflammasome in Hepatic Cells Under Oxygen –Glucose Deprivation/Reperfusion Injury
In conclusion, METTL3 knockdown alleviated OGD/R-induced hepatocyte injury, and the specific mechanism was associated with the inhibition of NLRP3 inflammasome activation, which was attributed to the reduction of TXNIP in an m6A-dependent manner. (Source: Inflammation)
Source: Inflammation - January 18, 2024 Category: Allergy & Immunology Source Type: research

Alpha-7 Nicotinic Receptor Agonist Protects Mice Against Pulmonary Emphysema Induced by Elastase
AbstractPulmonary emphysema is a primary component of chronic obstructive pulmonary disease (COPD), a life-threatening disorder characterized by lung inflammation and restricted airflow, primarily resulting from the destruction of small airways and alveolar walls. Cumulative evidence suggests that nicotinic receptors, especially the α7 subtype (α7nAChR), is required for anti-inflammatory cholinergic responses. We postulated that the stimulation of α7nAChR could offer therapeutic benefits in the context of pulmonary emphysema. To investigate this, we assessed the potential protective effects of PNU-282987, a selective α...
Source: Inflammation - January 16, 2024 Category: Allergy & Immunology Source Type: research

Hypoxia-Mediated Upregulation of Xanthine Oxidoreductase Causes DNA Damage of Colonic Epithelial Cells in Colitis
In this study, we investigated the role of XOR in ulcerative colitis (UC) and attempted to identify the underlying mechanisms. We used the dextran  sulfate sodium (DSS)–induced mouse model to mimic UC and observed that XOR inhibitors, allopurinol and diphenyleneiodonium sulfate (DPI), significantly alleviated UC in mice. In addition, treatment with cobalt chloride (CoCl2) and 1% O2 increased the expression of XOR and induced DNA oxidative damage in colonic epithelial cells. Furthermore, we identified that XOR accumulation in the nucleus may directly cause DNA oxidative damage and regulates HIF1 α protein levels. In ad...
Source: Inflammation - January 11, 2024 Category: Allergy & Immunology Source Type: research

Lack of Annexin A1 Exacerbates Inflammatory Response in Acute Endometritis Model
In conclusion, a lack of endogenous AnxA1 exacerbated the inflammatory response in an endometritis modelvia NLRP3 dysregulation, increased uterine mast cell activation, and plasma pro-inflammatory cytokine release. (Source: Inflammation)
Source: Inflammation - January 10, 2024 Category: Allergy & Immunology Source Type: research

4-Octyl Itaconate Inhibits Proinflammatory Cytokine Production in Behcet ’s Uveitis and Experimental Autoimmune Uveitis
Abstract4-octyl itaconate (4-OI) is an anti-inflammatory metabolite that activates the nuclear-factor-E2-related factor 2 (NRF2) signaling. In the current work, we investigated whether 4-OI could affect the production of proinflammatory cytokines in Behcet ’s uveitis (BU) and experimental autoimmune uveitis (EAU). Peripheral blood mononuclear cells (PBMCs) of active BU patients and healthy individuals within vitro 4-OI treatment were performed to assess the influence of 4-OI on the proinflammatory cytokine production. EAU was induced and used for investigating the influence of 4-OI on the proinflammatory cytokine product...
Source: Inflammation - January 6, 2024 Category: Allergy & Immunology Source Type: research

Scutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF- β-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2/3 Signaling Pathways
In conclusion, scutellarin can inactivate the Smad/MAPK pathways to suppress the TGF- β1-stimulated epithelial fibrosis and EMT and relieve airway inflammation and remodeling in asthma. This study provides a potential therapeutic strategy for asthma. (Source: Inflammation)
Source: Inflammation - January 2, 2024 Category: Allergy & Immunology Source Type: research

Sodium Butyrate Ameliorates Atopic Dermatitis-Induced Inflammation by Inhibiting HDAC3-Mediated STAT1 and NF- κB Pathway
AbstractA topic dermatitis (AD) is a common chronic and recurrent skin disorder. The protective effects of sodium butyrate (NaB), a metabolite of short-chain fatty acid breakdown by the gut microbiota, have been widely reported in numerous inflammatory diseases. However, the effect of NaB treatment alone on AD has not been reported. In the current study, AD was induced in BALB/c mice with 2,4-dinitrochlorobenzene (DNCB) for 28 days with NaB (200 mg/kg) treatment by gavage. NaB attenuated AD-induced skin bleeding, scarring, dryness, abrasions and erosions. In addition, NaB inhibited inflammatory cells infiltration and atten...
Source: Inflammation - December 30, 2023 Category: Allergy & Immunology Source Type: research