Comprehensive risk factor predictions for 3-year survival among HIV-associated and disseminated cryptococcosis involving lungs and central nervous system
ConclusionsIL-1RA is a biomarker for predicting 3-year survival. Further investigations to explore the pathogenetic role of IL-1RA in HIV-associated disseminated cryptococcosis and as a potential therapeutic target are warranted. (Source: Infection)
Source: Infection - April 13, 2024 Category: Infectious Diseases Source Type: research
Predictive performance of NEWS and qSOFA in immunocompromised sepsis patients at the emergency department
ConclusionIn contrast to NEWS, qSOFA underestimates the risk of adverse outcome in patients using high-dose glucocorticoids. As a clinical consequence, to adequately assess the severity of illness among immunocompromised patients, health care professionals should best use the NEWS. (Source: Infection)
Source: Infection - April 12, 2024 Category: Infectious Diseases Source Type: research
Detection of virus-specific T cells via ELISpot corroborates early diagnosis in human Borna disease virus 1 (BoDV-1) encephalitis
ConclusionThis case demonstrates that BoDV-1 ELISpot serves as additional diagnostic tool even in the first week after hospitalisation of patients with BoDV-1 encephalitis. (Source: Infection)
Source: Infection - April 12, 2024 Category: Infectious Diseases Source Type: research
Predictive performance of NEWS and qSOFA in immunocompromised sepsis patients at the emergency department
ConclusionIn contrast to NEWS, qSOFA underestimates the risk of adverse outcome in patients using high-dose glucocorticoids. As a clinical consequence, to adequately assess the severity of illness among immunocompromised patients, health care professionals should best use the NEWS. (Source: Infection)
Source: Infection - April 12, 2024 Category: Infectious Diseases Source Type: research
Detection of virus-specific T cells via ELISpot corroborates early diagnosis in human Borna disease virus 1 (BoDV-1) encephalitis
ConclusionThis case demonstrates that BoDV-1 ELISpot serves as additional diagnostic tool even in the first week after hospitalisation of patients with BoDV-1 encephalitis. (Source: Infection)
Source: Infection - April 12, 2024 Category: Infectious Diseases Source Type: research
Real-world effectiveness of sotrovimab for the treatment of SARS-CoV-2 infection during Omicron BA.2 and BA.5 subvariant predominance: a systematic literature review
ConclusionsThis systematic literature review suggests continued effectiveness of sotrovimab in preventing severe clinical outcomes during BA.2 and BA.5 predominance, both against active/untreated comparators and compared with BA.1 predominance. (Source: Infection)
Source: Infection - April 11, 2024 Category: Infectious Diseases Source Type: research
Estimates of global and regional prevalence of Helicobacter pylori infection among individuals with obesity: a systematic review and meta-analysis
ConclusionThe findings have the potential to influence future health policies for preventing and treatingH. pylori infection. However, there is variability among the included studies, indicating the need for more population-based research. (Source: Infection)
Source: Infection - April 10, 2024 Category: Infectious Diseases Source Type: research
Sapovirus: an emerging pathogen in kidney transplant recipients?
ConclusionIn high-risk patients, early symptomatic treatment remains crucial to protect the transplant`s function. In our cohort all patients recovered well. Larger cohorts and longer follow-up times are needed to detect the long-term consequences and a potential need for further research regarding specific treatment.Trial registrationThe study has been registered on DRKS (trialsearch.who.int), Reg. Nr. DRKS00033311 (December 28th 2023). (Source: Infection)
Source: Infection - April 9, 2024 Category: Infectious Diseases Source Type: research
The projected increase of vertebral osteomyelitis in Germany implies a demanding challenge for future healthcare management of aging populations
ConclusionsOur data suggest that increasing IR of VO will seriously challenge healthcare systems, particularly due to demographic change and increasing proportions of populations turning 75 years and older. With respect to globally fast aging populations, future health care policies need to address this burden by anticipating limitations in financial and human resources and developing high-level evidence-based guidelines for prevention and interdisciplinary treatment. (Source: Infection)
Source: Infection - April 9, 2024 Category: Infectious Diseases Source Type: research
Sapovirus: an emerging pathogen in kidney transplant recipients?
ConclusionIn high-risk patients, early symptomatic treatment remains crucial to protect the transplant`s function. In our cohort all patients recovered well. Larger cohorts and longer follow-up times are needed to detect the long-term consequences and a potential need for further research regarding specific treatment.Trial registrationThe study has been registered on DRKS (trialsearch.who.int), Reg. Nr. DRKS00033311 (December 28th 2023). (Source: Infection)
Source: Infection - April 9, 2024 Category: Infectious Diseases Source Type: research
The projected increase of vertebral osteomyelitis in Germany implies a demanding challenge for future healthcare management of aging populations
ConclusionsOur data suggest that increasing IR of VO will seriously challenge healthcare systems, particularly due to demographic change and increasing proportions of populations turning 75 years and older. With respect to globally fast aging populations, future health care policies need to address this burden by anticipating limitations in financial and human resources and developing high-level evidence-based guidelines for prevention and interdisciplinary treatment. (Source: Infection)
Source: Infection - April 9, 2024 Category: Infectious Diseases Source Type: research
Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON)
ConclusionThe PCS score correlated with patients ’ QoL and demonstrated to be instructive for clinical characterization and stratification across health care settings. Further studies should critically address the high prevalence, clinical relevance, and the role of comorbidities.Trail registration numberThe cohort is registered atwww.clinicaltrials.gov under NCT04768998. (Source: Infection)
Source: Infection - April 8, 2024 Category: Infectious Diseases Source Type: research
