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Beyond Bone Mineral Density: The Impact of Childhood Cancer and Its Treatment on Bone Structure and Strength
Front Horm Res. 2021;54:69-90. doi: 10.1159/000518501. Epub 2021 Sep 30.ABSTRACTThe spectrum of bone morbidity in childhood cancer survivors (CCS) is broad and extends beyond "low bone mineral density" to structural damage including fracture-induced vertebral deformity, and joint collapse due to osteonecrosis or slipped capital femoral epiphysis. In addition, short stature, scoliosis, leg length discrepancy, and vertebral deformity can arise from critical interference with growth plate activity. In some cases, insufficient residual growth potential or irreversible growth plate damage can lead to permanent structural deform...
Source: Frontiers of Hormone Research - November 1, 2021 Category: Endocrinology Authors: Melissa Fiscaletti Nathalie Alos Leanne M Ward Source Type: research