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Acesulfame potassium upregulates PD-L1 in HCC cells by attenuating autophagic degradation
Biochem Biophys Res Commun. 2024 Apr 9;711:149921. doi: 10.1016/j.bbrc.2024.149921. Online ahead of print.ABSTRACTArtificial sweeteners, which contain no or few calories, have been widely used in various foods and beverages, and are regarded as safe alternatives to sugar by the Food and Drug Administration. While several studies suggest that artificial sweeteners are not related to cancer development, some research has reported their potential association with the risk of cancers, including hepatocellular carcinoma (HCC). Here, we investigated whether acesulfame potassium (Ace K), a commonly used artificial sweetener, indu...
Source: Cell Research - April 11, 2024 Category: Cytology Authors: Dong-Ho Kim Eun-Jun Kwon Keun-Gyu Park Jonghwa Jin Jun-Kyu Byun Source Type: research

Infections Associated with Medtronic Duet External Ventricular Drains - Rhode Island Hospital, Providence, Rhode Island, January 2023-January 2024
MMWR Morb Mortal Wkly Rep. 2024 Apr 11;73(14):312-316. doi: 10.15585/mmwr.mm7314a4.ABSTRACTExternal ventricular drains (EVDs) are medical devices that are inserted into the ventricles of the brain to drain excess fluid, manage intracranial hypertension, monitor intracranial pressure, and administer medications. Unintentional disconnections and breaks or fractures (breaks) of EVDs or associated drainage system components can result in cerebrospinal fluid (CSF) leakage and increased risk for EVD-associated infections. After replacement of Integra Life Sciences EVD systems with Medtronic Duet EVD systems at Rhode Island Hospi...
Source: MMWR Morb Mortal Wkl... - April 11, 2024 Category: Epidemiology Authors: Kevin M Gibas Dianne Auld Stephanie Parente Jean Horoho Leonard A Mermel Source Type: research

Method development and validation for the estimation of gedatolisib in mouse plasma by tandem mass spectrometry and its application to pharmacokinetics studies
Biomed Chromatogr. 2024 Apr 10:e5878. doi: 10.1002/bmc.5878. Online ahead of print.ABSTRACTA simple and a sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of gedatolisib in mouse plasma. The extraction technique involved a simple precipitation method to extract gedatolisib and idelalisib (internal standard) from mouse plasma. A clean chromatographic separation of gedatolisib and the internal standard was achieved on an Atlantis dC18 column using an isocratic mobile phase (10 mm ammonium formate and acetonitrile; 30:70% v/v, both supplemented with 0.1% formic...
Source: Biomedical Chromatography : BMC - April 11, 2024 Category: Biomedical Science Authors: Vinod A B Arunava Das Source Type: research

Acesulfame potassium upregulates PD-L1 in HCC cells by attenuating autophagic degradation
Biochem Biophys Res Commun. 2024 Apr 9;711:149921. doi: 10.1016/j.bbrc.2024.149921. Online ahead of print.ABSTRACTArtificial sweeteners, which contain no or few calories, have been widely used in various foods and beverages, and are regarded as safe alternatives to sugar by the Food and Drug Administration. While several studies suggest that artificial sweeteners are not related to cancer development, some research has reported their potential association with the risk of cancers, including hepatocellular carcinoma (HCC). Here, we investigated whether acesulfame potassium (Ace K), a commonly used artificial sweetener, indu...
Source: Biochemical and Biophysical Research communications - April 11, 2024 Category: Biochemistry Authors: Dong-Ho Kim Eun-Jun Kwon Keun-Gyu Park Jonghwa Jin Jun-Kyu Byun Source Type: research

Risk of SARS-CoV-2 infection in patients with hematologic diseases receiving tixagevimab/cilgavimab as pre-exposure prophylaxis in most recent Omicron sublineages era
Although the overall mortality during SARS-CoV-2 Omicron variants of concern (VoC) wave might be lower than that seen with other previous VoCs immunocompromised individuals remain at increased the risk of hospitalization and prolonged duration of the infection compared to the general population [1]. Moreover, persons with immunosuppression may experience reduced vaccine immune response with an impaired seroconversion and effectiveness [2]. To address the need to protect these individuals from breakthrough infections and possibly from long-lasting SARS-CoV-2 infections, in December 2021 the combination tixagevimab/cilgavima...
Source: International Journal of Infectious Diseases - April 11, 2024 Category: Infectious Diseases Authors: Alessandra Vergori, Alessandro Cozzi Lepri, Marta Chiuchiarelli, Valentina Mazzotta, Elisabetta Metafuni, Giulia Matusali, Valentina Siciliano, Jessica Paulicelli, Eleonora Alma, Agostina Siniscalchi, Simona Sica, Elisabetta Abruzzese, Massimo Fantoni, An Tags: Short Communication Source Type: research

Patient reported outcome measures (PRO) in colorectal surgery
Surg Open Sci. 2024 Mar 28;19:66-69. doi: 10.1016/j.sopen.2024.03.013. eCollection 2024 Jun.ABSTRACTPatient reported outcomes refer to, "Any report of the status of a patient's health condition that comes directly from the patient, without interpretation of the patient's response by a clinician or anyone else" (US Food and Drug Administration, 2009) [1]. These outcomes can include anything that matters to patients including quality of life, pain, number of bowel movements. Patient reported outcome measures refer to tools or instruments that help to measure these outcomes. These measures can be done using validated tools, t...
Source: Pain Physician - April 10, 2024 Category: Anesthesiology Authors: Kathia E Nitsch Srinivas J Ivatury Source Type: research

GSE263394 Dolutegravir induces FOLR1 expression during brain organoid development.
Contributors : Daniel Kraushaar ; Carlo Donato Caiaffa ; Robert M CabreraSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensThe brain and spinal cord are formed during neurulation, a developmental process that occurs during the first month of pregnancy and can be modified by low serum levels of folic acid (FA), environmental factors, or genetic predispositions. In 2018, data from a surveillance study in Botswana, a country with one of the highest incidences of human immunodeficiency virus (HIV) and lacking mandatory food folate fortification programs, revealed an increased risk of neur...
Source: GEO: Gene Expression Omnibus - April 10, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies
Arch Pharm Res. 2024 Apr 9. doi: 10.1007/s12272-024-01493-2. Online ahead of print.ABSTRACTSarcopenia is a multifactorial condition characterized by loss of muscle mass. It poses significant health risks in older adults worldwide. Both pharmacological and non-pharmacological approaches are reported to address this disease. Certain dietary patterns, such as adequate energy intake and essential amino acids, have shown positive outcomes in preserving muscle function. Various medications, including myostatin inhibitors, growth hormones, and activin type II receptor inhibitors, have been evaluated for their effectiveness in man...
Source: Archives of Pharmacal Research - April 9, 2024 Category: Drugs & Pharmacology Authors: Youle Zheng Jin Feng Yixin Yu Min Ling Xu Wang Source Type: research