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Improvement in HCV patients with advanced, compensated liver disease after SVR to antivirals
ConclusionsIn patients advanced, compensated chronic liver disease, liver stiffness significantly improves in the long ‐term after SVR, and this improvement is accompanied by an amelioration of indirect indices of liver fibrosis and function, and by a decrease in parameters of portal hypertension.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 26, 2018 Category: General Medicine Authors: Edoardo G. Giannini, Mattia Crespi, Mariagiulia Demarzo, Giorgia Bodini, Manuele Furnari, Elisa Marabotto, Francesco Torre, Patrizia Zentilin, Vincenzo Savarino Tags: Original Paper Source Type: research

A single preoperative blood test predicts postoperative sepsis and pneumonia after coronary bypass or open aneurysm surgery
ConclusionElevated RDW associates with increased risk for postoperative inflammatory complications and hematopoietic tissue activity. RDW likely reflects chronic low ‐grade inflammation and should be considered to identify patients at risk for postoperative inflammatory complications following cardiovascular surgery.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 26, 2018 Category: General Medicine Authors: Ian D. van Koeverden, Hester M. den Ruijter, Vincent P.W. Scholtes, Marnix G.E.H. Lam, Saskia Haitjema, Marc P. Buijsrogge, Willem J.L. Suyker, Richard H. van Wijk, Mark C.H. de Groot, Joost A. van Herwaarden, Wouter W. van Solinge, Gert J. de Tags: Original Paper Source Type: research

New insights on the role of DNA methylation in cardiovascular disease
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 20, 2018 Category: General Medicine Authors: Nicholas Bardi, Federico Carbone, Fabrizio Montecucco Tags: Commentary Source Type: research

Elevated urinary orosomucoid excretion as a novel biomarker in Crohn's disease
ConclusionsOur findings suggest that u ‐ORM/u‐CREAT might serve as a valuable additional marker in the follow‐up of CD patients, especially in children for whom the non‐invasive sampling is a further advantage.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 19, 2018 Category: General Medicine Authors: Bal ázs Szirmay, András Tárnok, Patrícia Sarlós, Nóra Szigeti, Andrea Ludány, Péter Kustán, Zoltán Horváth‐Szalai, Attila Miseta, Tamás Kőszegi Tags: Original Paper Source Type: research

Pericardial adipose tissue and cardiovascular diseases: new insights from basic research
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 19, 2018 Category: General Medicine Authors: Luca Liberale, Federico Carbone, Fabrizio Montecucco Tags: Commentary Source Type: research

Lipoprotein(a) and Low ‐density lipoprotein apolipoprotein‐B metabolism following apheresis in patients with elevated lipoprotein(a) and coronary artery disease
ConclusionsIn patients with elevated Lp(a), the fractional catabolism of Lp(a) is slower than that of LDL ‐apoB particles, implying that different metabolic pathways are involved in the catabolism of these lipoproteins. These findings have implications for new therapies for lowering apolipoprotein(a) and apoB to prevent atherosclerotic cardiovascular disease.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 17, 2018 Category: General Medicine Authors: Louis Ma, Elisa Waldmann, Esther M. M. Ooi, Dick C. Chan, Hugh P. R. Barrett, Gerald F. Watts, Klaus G. Parhofer Tags: Original Paper Source Type: research

Leptin and the vasculature in young adults: The African ‐PREDICT study
ConclusionIn young healthy men, we found a beneficial inverse association between measures of carotid wall thickness and circulating leptin, thereby supporting a potential vascular protective role of leptin. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 16, 2018 Category: General Medicine Authors: Blessing O. Ahiante, Wayne Smith, Leandi Lammertyn, Aletta E. Schutte Tags: ORIGINAL ARTICLE Source Type: research

Effects of acute fructose loading on levels of serum uric acid —a pilot study
ConclusionsIntake of fructose increases serum uric acid. The fructose intake via a blueberry drink induced lowest increase and thus may be protective. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 16, 2018 Category: General Medicine Authors: Camilla Olofsson, Bj örn Anderstam, Ann‐Christin Bragfors‐Helin, Monica Eriksson, Abdul R. Qureshi, Bengt Lindholm, Agneta Hilding, Wieslaw Wiczkowski, Nicola Orsini, Peter Stenvinkel, Neda Rajamand Ekberg Tags: ORIGINAL ARTICLE Source Type: research

Predictors of cardiovascular outcome and rehospitalization in elderly patients with heart failure
ConclusionsIn elderly subjects with chronic HF, the risk stratification could benefit of a multiparametric approach combining biochemical, echocardiographic, demographic and socioeconomical parameters, thus ensuring a better quality of life and at the same time a better allocation of financial resources. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 16, 2018 Category: General Medicine Authors: Gian M. Rosa, Riccardo Scagliola, Paola Ghione, Alberto Valbusa, Claudio Brunelli, Federico Carbone, Fabrizio Montecucco, Fiammetta Monacelli Tags: REVIEW Source Type: research

Pulse wave velocity to global longitudinal strain ratio in hypertension
ConclusionsPulse wave velocity ‐to‐global longitudinal strain ratio but not the echocardiography‐derived arterial elastance‐to left ventricular elastance index is related to impaired carotid‐intima media thickness, coronary‐flow reserve and diastolic function in hypertensives.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 13, 2018 Category: General Medicine Authors: Ignatios Ikonomidis, Spyridon Katsanos, Hellen Triantafyllidi, John Parissis, Stavros Tzortzis, George Pavlidis, Paraskevi Trivilou, Georgios Makavos, Maria Varoudi, Alexandra Frogoudaki, Agathi ‐Rosa Vrettou, Dimitrios Vlastos, John Lekakis Tags: Original Paper Source Type: research

Increasing Therapy Related Myeloid Neoplasms in Multiple Myeloma
ConclusionsThough the improvement in MM outcome during the last decades is an unprecedented achievement, it has been accompanied by the rise in TRM malignancies with complex cytogenetic profile and poor prognosis that are in the need of an improved biologic and therapeutic approach.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 13, 2018 Category: General Medicine Authors: M. Fern ández‐Caballero, D. Salmerón, M D Chirlaque, D. Salmerón, T H Chen‐Liang, A M. Hurtado, M D García Malo, F J Ortuño, V. Roldán, V. Vicente, A. Jerez, F. De Arriba Tags: Original Paper Source Type: research

Leukocyte Adhesion Deficiency –A Multicenter National Experience
This article is protected by copyright. All rights reserved (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 9, 2018 Category: General Medicine Authors: Baruch Wolach, Ronit Gavrieli, Ofir Wolach, Tal Stauber, Omar Abuzaitoun, Amir Kuperman, Yaakov Amir, Polina Stepensky, Raz Somech, Amos Etzioni Tags: Original Paper Source Type: research

Accuracy of new recommendations for adrenal incidentalomas in the evaluation of excessive cortisol secretion and follow ‐up
ConclusionAlthough adrenal incidentalomas with an excess of cortisol secretion were more frequently diagnosed with the new ESE recommendations, patients who did not require longer follow ‐up after first evaluation were accurately classified.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 9, 2018 Category: General Medicine Authors: A. Ruiz, T. Michalopoulou, A. Megia, S. N äf, I. Simón‐Muela, E. Solano, L. Martínez, J. Vendrell Tags: Original Paper Source Type: research

CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease
ConclusionIn this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone marrow for clearance under homeostasis and disease. We also discuss the role of CXCR4 in fine ‐tuning neutrophil responses in the context of inflammation. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 7, 2018 Category: General Medicine Authors: Katia De Filippo, Sara M. Rankin Tags: REVIEW Source Type: research

Issue Information
European Journal of Clinical Investigation, Volume 48, Issue S2, November 2018. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 7, 2018 Category: General Medicine Tags: ISSUE INFORMATION Source Type: research