Characterization of Diclofenac-induced Renal Damage in Normotensive
and Hypertensive Rats: A Comparative Analysis
Conclusions The data presented herein demonstrated that diclofenac induces
renal damage and impaired renal function in both NTR and SHR, but those effects
are exacerbated in SHR, as seen by the histological changes and electrolytes
balance disturbance, therefore, reinforcing that diclofenac may increase the
risks of cardiovascular events in hypertensive patients. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - March 19, 2024 Category: Drugs & Pharmacology Authors: Boeing, Thaise Lima, Alana Bittencourt F. Busana, Maria Eduarda Mariano, Lu ísa Nathália Bolda da Silva, Luisa Mota Silva, Rita de C ássia Vilhena da de Souza, Priscila Tags: Original Article Source Type: research
Perspectives About Ascorbic Acid to Treat Inflammatory Bowel
Diseases
Drug Res (Stuttg) DOI: 10.1055/a-2263-1388It is known that reactive oxygen species cause abnormal immune responses in the
gut during inflammatory bowel diseases (IBD). Therefore, oxidative stress has
been theorized as an agent of IBD development and antioxidant compounds such as
vitamin C (L-ascorbic acid) have been studied as a new tool to treat IBD.
Therefore, the potential of vitamin C to treat IBD was reviewed here as a
critical discussion about this field and guide future research. Indeed, some
preclinical studies have shown the beneficial effects of vitamin ...
Source: Drug Research - March 11, 2024 Category: Drugs & Pharmacology Authors: Andriolo, Ian Richard Lucena Venzon, Larissa da Silva, Luisa Mota Tags: Review Source Type: research
An Observational Study on Cosmetics Use-related Adverse Effects:
Cosmetovigilance Need of the Day
Conclusion To improve the system’s efficiency, a comprehensive review of
the current regulatory protocols for cosmetics is crucial. Additionally, it is
essential to widely disseminate information on Cosmetovigilance and promote the
reporting of any adverse effects of cosmetics within the community; this is the
demand of the present time. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - March 11, 2024 Category: Drugs & Pharmacology Authors: Mehta, Geetika Tyagi, Daksh Raj Sachdeva, Monika Tripathi, Rashmi Tyagi, Himanshu Tags: Original Article Source Type: research
Therapeutic Potential of Diosgenin in Amelioration of Carbon
Tetrachloride-Induced Murine Liver Injury
Drug Res (Stuttg) DOI: 10.1055/a-2263-1329Diosgenin is a sapogenin with antidiabetic, antioxidant, and anti-inflammatory
properties. The current study investigated whether diosgenin could ameliorate
carbon tetrachloride (CCL4)-induced liver injury. To cause liver injury, CCL4
was injected intraperitoneally twice a week for 8 weeks. Daily oral
administration of diosgenin at doses of 20, 40, and 80 mg/kg was started one day
before CCL4 injection and continued for 8 weeks. Finally, serum levels of
aspartate aminotransferase (AST), alanine aminotransferase (ALT), an...
Source: Drug Research - March 8, 2024 Category: Drugs & Pharmacology Authors: Ghosian-Moghaddam, Mohamad-Hasan Mohseni-Moghaddam, Parvaneh Roghani, Mehrdad Tags: Original Article Source Type: research
Encyclopaedic Review of Glipizide Pre-clinical and Clinical
Status
In conclusion, glipizide has shown promising
therapeutic efficacy across a variety of disorders. [...] Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - February 26, 2024 Category: Drugs & Pharmacology Authors: Mohammad, Saad Mahmood, Tarique Shamim, Arshiya Ahsan, Farogh Shariq, Mohammad Parveen, Saba Waseem, Rufaida Singh, Aditya Tags: Review Source Type: research
From Hypertension to Beyond: Unraveling the Diverse Mechanisms of
Olmesartan in Disease Modulation
Drug Res (Stuttg) DOI: 10.1055/a-2244-3136Olmesartan, originally known for its antihypertensive properties, exhibits
promising potential in addressing inflammation-mediated diseases. As an
angiotensin II receptor blocker (ARB), Olmesartan influences pivotal pathways,
including reactive oxygen species, cytokines, NF-κB, TNF-α, and
MAPK. This suggests a viable opportunity for repurposing the drug in conditions
such as ulcerative colitis, neuropathy, nephropathy, and cancer, as supported by
multiple preclinical studies. Ongoing clinical trials, particularly in
...
Source: Drug Research - February 13, 2024 Category: Drugs & Pharmacology Authors: Rind, Laiba Mahmood, Tarique Siddiqui, Mohammed Haris Ahsan, Farogh Shamim, Arshiya Anwar, Aamir Yadav, Rajnish Kumar Tags: Review Source Type: research
The Perspective of Using Flow Cytometry for Unpuzzling
Hypoxia-Inducible Factors Signalling
Drug Res (Stuttg) DOI: 10.1055/a-2248-9180Hypoxia-inducible factors (HIFs) are transcription factors that are responsible
for adapting to the changes in oxygen levels in the cellular environment. HIF
activity determines the expression of cellular proteins that control the
development and physiology of the cells and pathophysiology of a disease.
Understanding the role of specific HIF (HIF-1-3) in cellular function is
essential for development of the HIF-targeted therapies. In this review, we have
discussed the use of flow cytometry in analysing HIF function in cell...
Source: Drug Research - February 13, 2024 Category: Drugs & Pharmacology Authors: Patel, Vishal J. Joharapurkar, Amit Jain, Mukul R. Tags: Review Source Type: research
Understanding the Potential of mRNA as Biomarker to Revolutionize
Diagnosis of Colorectal Cancer
Drug Res (Stuttg) DOI: 10.1055/a-2244-6572MicroRNA as potential biomarker for early diagnosis, differentiating various
stages, interpreting the success of postoperative curative surgery and
predicting early relapse of Colorectal cancer.In the realm of medical research, the quest to find effective biomarkers for
various diseases has always been a top priority. Colorectal cancer (CRC), one of
the leading causes of cancer-related deaths worldwide, is no exception. The
emergence of microRNA (mRNA) as a potential biomarker for CRC has sparked
immense interest among scien...
Source: Drug Research - February 13, 2024 Category: Drugs & Pharmacology Authors: Das, Rina Mehta, Dinesh Kumar Gupta, Nidhi Tags: Review Source Type: research
Protective Effects of Xanthine Derivatives Against Arsenic
Trioxide-Induced Oxidative Stress in Mouse Hepatic and Renal
Tissues
In this study, the protective efficacy of pentoxifylline (PTX) as a xanthine
derivative against arsenic trioxide (ATO)-induced kidney and liver damage in
mice was investigated. Thirty-six mice were divided into six groups, receiving
intraperitoneal injections of saline, ATO, PTX, or a combination for four weeks.
Blood samples were analyzed for serum biochemistry, while hepatic tissue
underwent examination for histopathological changes and assessment of oxidative
stress markers and antioxidant gene expression through Real-Time PCR. ATO
exposure significan...
Source: Drug Research - February 13, 2024 Category: Drugs & Pharmacology Authors: Omidifar, Navid Gholami, Ahmad Shokripour, Mansoureh Nourani, Mohammad Ali Mohkam, Milad Mousavi, Seyyed Mojtaba Hashemi, Seyyed Alireza Khorram, Bagher Ahmadabadi, Amir Nili Dara, Mahintaj Tags: Original Article Source Type: research
In-silico, Synthesis, Characterization, and In-vitro
Studies on Benzylidene-based 2-chloroquinolin Derivatives as Free Radical
Scavengers in Parkinson ’s Disease
Drug Res (Stuttg) 2024; 74: 67-76 DOI: 10.1055/a-2231-1311Parkinson’s disease is the loss of dopaminergic neurons in the
substantial nigra part of the brain leading to neurodegeneration. Whereas,
reactive oxygen species and mitochondrial impairment are considered to be the
major pathophysiology of neurodegeneration. The benzylidene-based
2-chloroquinolin derivatives were synthesized and characterized by FT-IR, NMR,
and MS spectrometry which were screened using various in-silico
approaches. The designed compounds were further assessed using in-vitro
cyt...
Source: Drug Research - February 12, 2024 Category: Drugs & Pharmacology Authors: Subramanian, Gomathy Prasad, Kaveri Chand, Jagdish Amarjith, Thiyyar K. Shanish, Antony A. Tags: Original Article Source Type: research
Effects of SGLT2 Inhibitors and DPP-4 Inhibitors on Advanced
Glycation End Products
Drug Res (Stuttg) DOI: 10.1055/a-2234-1797Clinical trials have revealed that sodium glucose cotransporter 2 (SGLT2)
inhibitors suppress the onset of heart failure and cardiovascular death in
diabetic patients. On the other hand, few reports have been published concerning
such effects of dipeptidyl peptidase-4 (DPP-4) inhibitors. We undertook the
present study to evaluate the effects of SGLT2 inhibitors and DPP-4 inhibitors
on the advanced glycation end products (AGEs), well known as a risk factor for
the development of cardiovascular disorders.Type 2 diabetes mell...
Source: Drug Research - January 29, 2024 Category: Drugs & Pharmacology Authors: Kusunoki, Masataka Hisano, Fumiya Matsuda, Shin-ichi Kusunoki, Akiko Abe, Tomokazu Tsutsumi, Kazuhiko Miyata, Tetsuro Tags: Original Article Source Type: research
Design, Synthesis and In Vitro Evaluation of Levodopa Stearic
Acid Hydrazide Conjugate for the Management of Parkinson ’s DiseaseNovel
Conjugate for Parkinson’s Disease
Drug Res (Stuttg) DOI: 10.1055/a-2234-9859Parkinson’s disease is the highest prevalent neurodegenerative disease in
elderly individuals after Alzheimer’s disease. The pathological
identification for Parkinson’s disease is loss of dopaminergic neurons
in substantia nigra region of the brain that in turn leads to dopamine
deficiency that affects the body’s normal physiological and neurological
disorder. The important drawback in the modality of treatment is levodopa is
only supplying depleted dopamine in the brain, it does not affect
neurodegenerat...
Source: Drug Research - January 29, 2024 Category: Drugs & Pharmacology Authors: Chinraj, Vasanthi Reddy, Ramakkamma Aishwarya Selvaraj, Jubie Sureshkumar, Raman Tags: Original Article Source Type: research
Therapeutic Effects of Tamsulosin in Nightmare Disorder: A
Randomized, Double Blind, Placebo-Controlled, Cross-Over, Pilot
Study
Drug Res (Stuttg) DOI: 10.1055/a-2226-3604Nightmare disorder is associated with functional impairment, distress, and low
quality of life; however, studies on pharmacotherapy of this debilitating
disorder yielded mixed results. Prazosin, a non-selective α1
blocker is reported to be effective in treatment of post-traumatic stress
disorder-related nightmares. We aimed at investigating therapeutic effects of
tamsulosin which has higher affinity for blocking α1A and
α1D adrenoceptors in treatment of nightmare disorder. A
randomized, double blind, cross-o...
Source: Drug Research - January 18, 2024 Category: Drugs & Pharmacology Authors: Naderifar, Negin Roohi, Elnaz Sharifi, Ali Jaafari, Nemat Hashemian, Farshad Tags: Original Article Source Type: research
Biological Activity of a Coumarin Derivative on Heart Failure Using
an Ischemia/Reperfusion Injury Model
Drug Res (Stuttg) DOI: 10.1055/a-2228-4258Heart failure is a health problem worldwide. There are some drugs for it,
including digoxin, spironolactone, captopril, and valsartan, but some of these
drugs can produce secondary effects, such as arrhythmia, cough, hyperkalemia,
hyponatremia and hypotension. The aim of this research was to evaluate the
biological activity of coumarin (2H-chromen-2-one) and its derivatives
(3BrAcet-C, 3–4Br-Ph-C, 4-CN-7D-C, 4-Me-7-Ph-C and 6Br-3-D-C) against
ischemia/reperfusion injury as a therapeutic alternative for heart
fa...
Source: Drug Research - January 17, 2024 Category: Drugs & Pharmacology Authors: Figueroa-Valverde, Lauro Rosas-Nexticapa, Marcela Alvarez-Ramirez, Magdalena Melgarejo-Guti érrez, Montserrat Mateu-Armand, Virginia Garcimarrero-Espino, Alejandra Tags: Original Article Source Type: research
Correction: Structure-Based Drug Design for Targeting IRE1: An in Silico
Approach for Treatment of Cancer
Drug Res (Stuttg) DOI: 10.1055/a-2235-8845 Georg Thieme Verlag Rüdigerstraße 14, 70469 Stuttgart,
GermanyArticle in Thieme eJournals: Table of contents | Full text (Source: Drug Research)
Source: Drug Research - January 11, 2024 Category: Drugs & Pharmacology Authors: Poustforoosh, Alireza Faramarz, Sanaz Nematollahi, Mohammad Hadi Mahmoodi, Mehdi Azadpour, Mahdiyeh Tags: Erratum Source Type: research
