Developmental Medicine and Child Neurology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Gait parameters in children with bilateral spastic cerebral palsy: a systematic review of randomized controlled trials
AimTo identify the gait parameters used to assess gait disorders in children with bilateral spastic cerebral palsy (CP) and evaluate their responsiveness to treatments.MethodA systematic search within PubMed, Web of Science, and Scopus (in English, 2000 –2016) for randomized controlled trials of children with bilateral spastic CP who were assessed by instrumented gait analysis (IGA) was performed. Data related to participants and study characteristics, risk of bias, and outcome measures were collected. A list of gait parameters responsive to clin ical interventions was obtained.ResultsTwenty ‐one articles met the inclu...
Source: Developmental Medicine and Child Neurology - November 28, 2018 Category: Child Development Authors: Cristina G ómez‐Pérez, Josep M Font‐Llagunes, Joan Carles Martori, Joan Vidal Samsó Tags: Systematic Review Source Type: research

Administrative databases to monitor the prevalence of cerebral palsy
Developmental Medicine&Child Neurology, EarlyView. (Source: Developmental Medicine and Child Neurology)
Source: Developmental Medicine and Child Neurology - November 27, 2018 Category: Child Development Authors: Elodie Sellier Tags: Commentary Source Type: research

Motor function in Rett syndrome: comparing clinical and parental assessments
AimTo describe a new clinical tool, the Rett Syndrome Motor Evaluation Scale (RESMES) and to assess (loco ‐)motor function in people with Rett syndrome (RTT).MethodFormal assessment provided by physicians was followed by parents ’ direct observation at home using the RESMES. Sixty females (mean [SD] age 12y 5mo [8y 9mo], range 3–40y) with a clinical diagnosis and genetically determined RTT participated in the study. Spearman's/Pearson's coefficients assessed the correlation between the clinicians’ and caregivers’ ev aluations, as well as the correlation of RESMES scores with other scales, namely the Pain Assessme...
Source: Developmental Medicine and Child Neurology - November 26, 2018 Category: Child Development Authors: Marina L Rodocanachi Roidi, Ioannis U Isaias, Francesca Cozzi, Francesca Grange, Fabrizia M Scotti, Valentina F Gestra, Alessandra Gandini, Enrico Ripamonti Tags: Original Article Source Type: research

Prefrontal and temporal cortical thickness in adolescents with traumatic brain injury
AimTo investigate the impact of traumatic injury on the developing prefrontal ‐temporal adolescent cortex, and correlated brain structural measures with neurocognitive functioning.MethodNineteen adolescents (12 males, 7 females, age range: 11 –17y, mean 15y 8mo, standard deviation 1y 7mo, median 15y 11mo) with traumatic brain injury (TBI) were included. Cortical thickness of frontal and temporal lobes was assessed using magnetic resonance imaging. We correlated cortical thickness of prefrontal‐temporal regions with age, time since in jury, and neurocognitive functioning, and compared these results with a matched cont...
Source: Developmental Medicine and Child Neurology - November 25, 2018 Category: Child Development Authors: Catharine Vander Linden, Helena Verhelst, Gregory Verleysen, Karen Caeyenberghs, Karel Deblaere, Guy Vingerhoets Tags: Original Article Source Type: research

Hamstring lengthening in cerebral palsy and the use of musculoskeletal modelling
Developmental Medicine&Child Neurology, EarlyView. (Source: Developmental Medicine and Child Neurology)
Source: Developmental Medicine and Child Neurology - November 25, 2018 Category: Child Development Authors: Caroline Stewart Tags: Commentary Source Type: research

The crisis in replicability
Developmental Medicine&Child Neurology, EarlyView. (Source: Developmental Medicine and Child Neurology)
Source: Developmental Medicine and Child Neurology - November 25, 2018 Category: Child Development Authors: Alan S Rigby, Steven M Day Tags: Commentary Source Type: research

Mycophenolate mofetil in the treatment of pediatric autoimmune central nervous system disease
Developmental Medicine&Child Neurology, EarlyView. (Source: Developmental Medicine and Child Neurology)
Source: Developmental Medicine and Child Neurology - November 25, 2018 Category: Child Development Authors: Cory Stingl, Heather Van Mater Tags: Commentary Source Type: research

Long ‐term muscle changes after hamstring lengthening in children with bilateral cerebral palsy
AimTo evaluate short ‐term (1y postoperatively; E1) and long‐term (at least 4y postoperatively; E2) changes in hamstring muscle‐tendon length (MTL) and lengthening velocity after hamstring lengthening in children with bilateral cerebral palsy (CP).MethodThree ‐dimensional gait analysis was performed in 19 children (16 males, 3 females; 36 limbs; mean age at surgery 9y [SD 3y]; range 6–10y) with flexed knee gait, preoperative ankle dorsiflexion lower than 20 degrees, and CP before bilateral hamstring lengthening (E0), at E1 and E2. Hamstring MTL (norm alized by leg length) and velocity were assessed via OpenSim so...
Source: Developmental Medicine and Child Neurology - November 25, 2018 Category: Child Development Authors: Firooz Salami, Julia Brosa, Stefan Van Drongelen, Matthias C M Klotz, Thomas Dreher, Sebastian I Wolf, Mirjam Thielen Tags: Original Article Source Type: research

Transcranial direct current stimulation in children with autism spectrum disorder: a systematic scoping review
AimOur aim was to review available studies which test transcranial direct current stimulation (tDCS) to reduce symptom severity in children with autism spectrum disorder (ASD).MethodWe performed a systematic scoping review in PubMed and PsychINFO databases for studies employing tDCS in children and adolescents with ASD.ResultsWe found five studies (two small randomized controlled studies, one experimental study, one quasi ‐experimental study, and one case study) reporting positive effects of tDCS in ASD symptom reduction. Study design varied greatly and sample size ranged from 1 to 20 patients.InterpretationPreliminary e...
Source: Developmental Medicine and Child Neurology - November 19, 2018 Category: Child Development Authors: Ana Alexandra Caldas Os ório, Andre Russowsky Brunoni Tags: Invited Review Source Type: research

How socio ‐economic disadvantage modifies health outcomes in children with cerebral palsy
Developmental Medicine&Child Neurology, EarlyView. (Source: Developmental Medicine and Child Neurology)
Source: Developmental Medicine and Child Neurology - November 16, 2018 Category: Child Development Authors: Maryam Oskoui, Carmen Messerlian Tags: Commentary Source Type: research

Missed outpatient appointments and unplanned healthcare: the real question is ‘why’?
Developmental Medicine&Child Neurology, EarlyView. (Source: Developmental Medicine and Child Neurology)
Source: Developmental Medicine and Child Neurology - November 16, 2018 Category: Child Development Authors: Jane V Appleton Tags: Commentary Source Type: research

Home ‐based early intervention in infants and young children with visual impairment using the Developmental Journal: longitudinal cohort study
AimTo investigate the effects of home ‐based early intervention in children with severe visual impairment using the Developmental Journal for babies and young children with visual impairment (DJVI).MethodA longitudinal observational study was undertaken with a national cohort (OPTIMUM) of infants with congenital disorders of the peripheral visual system (CDPVS) and profound ‐severe visual impairment; and followed up after 12 months and 24 months. Intervention was categorized according to the practitioner diary records of their usual practice over 12 months from baseline comparing those receiving the DJVI and those r...
Source: Developmental Medicine and Child Neurology - November 13, 2018 Category: Child Development Authors: Naomi J Dale, Elena Sakkalou, Michelle A O'Reilly, Clare Springall, Hanna Sakki, Sarah Glew, Eleni Pissaridou, Michelle De Haan, Alison T Salt Tags: Original Article Source Type: research

Acute flaccid myelitis: an emerging clinical entity
Developmental Medicine&Child Neurology, EarlyView. (Source: Developmental Medicine and Child Neurology)
Source: Developmental Medicine and Child Neurology - November 12, 2018 Category: Child Development Authors: Akihisa Okumura, Harushi Mori Tags: Commentary Source Type: research

Outcome of paediatric acute flaccid myelitis associated with enterovirus D68: a case series
We report five cases of AFM in previously typically developing children (2–6y) from South East Scotland during September and October 2016 after infection with EV‐D68 (all detected in the nasopharyngeal aspirates). All cases pr esented with significant neurological symptoms, which were severe in two cases requiring intensive care support because of respiratory paralysis. At 18‐month follow‐up, two cases remain ventilator‐dependent with other cases requiring ongoing community rehabilitation. These cases represent one of the largest reported paediatric cluster of AFM associated with EV‐D68 in Europe. The epidemiol...
Source: Developmental Medicine and Child Neurology - November 12, 2018 Category: Child Development Authors: Amir Kirolos, Kate Mark, Jay Shetty, Nandita Chinchankar, Catherine Mcdougall, Paul Eunson, Janet Stevenson, Kate Templeton, NHS Lothian EV ‐D68 Associated AFM Study Group Tags: Case Series Source Type: research

Autophagy in childhood neurological disorders
Autophagy is a tightly modulated lysosomal degradation pathway. Genetic disorders of autophagy during nervous system development may lead to developmental delay, neurodegeneration, and other neurological signs in children. Here we aimed to summarize single gene disorders that perturb various steps of autophagy pathway and their roles in the causation of childhood neurological diseases. Numerous childhood ‐onset disorders are caused by mutations that impact the autophagy pathway. These can manifest with a range of features including ataxia, spastic paraplegia, and intellectual disability. Defective proteins causing such d...
Source: Developmental Medicine and Child Neurology - November 12, 2018 Category: Child Development Authors: Ye Zhu, Gautam Runwal, Pawel Obrocki, David C Rubinsztein Tags: Invited Review Source Type: research