Case study observational research: inflammatory cytokines in the bronchial epithelial lining fluid of COVID-19 patients with acute hypoxemic respiratory failure
In this study, the concentrations of inflammatory cytokines were measured in the bronchial epithelial lining fluid (ELF) and plasma in patients with acute hypoxemic respiratory failure (AHRF) secondary to seve... (Source: Critical Care)
Source: Critical Care - April 23, 2024 Category: Intensive Care Authors: Kazuki Sudo, Mao Kinoshita, Ken Kawaguchi, Kohsuke Kushimoto, Ryogo Yoshii, Keita Inoue, Masaki Yamasaki, Tasuku Matsuyama, Kunihiko Kooguchi, Yasuo Takashima, Masami Tanaka, Kazumichi Matsumoto, Kei Tashiro, Tohru Inaba, Bon Ohta and Teiji Sawa Tags: Brief Report Source Type: research
Transforming research to improve therapies for trauma in the twenty-first century: an alternative perspective
(Source: Critical Care)
Source: Critical Care - April 23, 2024 Category: Intensive Care Authors: Geoffrey P. Dobson, Jodie L. Morris and Hayley L. Letson Tags: Matters Arising Source Type: research
Respiratory drive heterogeneity associated with systemic inflammation and vascular permeability in acute respiratory distress syndrome
In acute respiratory distress syndrome (ARDS), respiratory drive often differs among patients with similar clinical characteristics. Readily observable factors like acid –base state, oxygenation, mechanics, and... (Source: Critical Care)
Source: Critical Care - April 23, 2024 Category: Intensive Care Authors: Elias Baedorf-Kassis, Michael Murn, Amy L. Dzierba, Alexis L. Serra, Ivan Garcia, Emily Minus, Clarissa Padilla, Todd Sarge, Valerie M. Goodspeed, Michael A. Matthay, Michelle N. Gong, Deborah Cook, Stephen H. Loring, Daniel Talmor and Jeremy R. Beitler Tags: Research Source Type: research
Lower airway microbiota compositions differ between influenza, COVID-19 and bacteria-related acute respiratory distress syndromes
Acute respiratory distress syndrome (ARDS) is responsible for 400,000 deaths annually worldwide. Few improvements have been made despite five decades of research, partially because ARDS is a highly heterogeneo... (Source: Critical Care)
Source: Critical Care - April 22, 2024 Category: Intensive Care Authors: S ébastien Imbert, Mathilde Revers, Raphaël Enaud, Arthur Orieux, Adrian Camino, Alexandre Massri, Laurent Villeneuve, Cédric Carrié, Laurent Petit, Alexandre Boyer, Patrick Berger, Didier Gruson, Laurence Delhaes and Renaud Prével Tags: Brief Report Source Type: research
Rapidly improving ARDS differs clinically and biologically from persistent ARDS
Rapidly improving acute respiratory distress syndrome (RIARDS) is an increasingly appreciated subgroup of ARDS in which hypoxemia improves within 24 h after initiation of mechanical ventilation. Detailed clini... (Source: Critical Care)
Source: Critical Care - April 22, 2024 Category: Intensive Care Authors: Patricia L. Valda Toro, Andrew Willmore, Nelson E. Wu, Kevin L. Delucchi, Alejandra Jauregui, Pratik Sinha, Kathleen D. Liu, Carolyn M. Hendrickson, Aartik Sarma, Lucile P. A. Neyton, Aleksandra Leligdowicz, Charles R. Langelier, Hanjing Zhuo, Chayse Jone Tags: Research Source Type: research
Ventilator-associated pneumonia related to extended-spectrum beta-lactamase producing Enterobacterales during severe acute respiratory syndrome coronavirus 2 infection: risk factors and prognosis
Patients infected with the severe acute respiratory syndrome coronavirus 2 (SARS-COV 2) and requiring mechanical ventilation suffer from a high incidence of ventilator associated pneumonia (VAP), mainly relate... (Source: Critical Care)
Source: Critical Care - April 20, 2024 Category: Intensive Care Authors: Keyvan Razazi, Charles-Edouard Luyt, Guillaume Voiriot, Anahita Rouz é, Marc Garnier, Alexis Ferré, Laurent Camous, Nicholas Heming, Nathanaël Lapidus, Anais Charles-Nelson and Armand Mekontso-Dessap Tags: Research Source Type: research
Extracorporeal cardiopulmonary resuscitation versus conventional CPR in cardiac arrest: be aware of the temporal selection bias
(Source: Critical Care)
Source: Critical Care - April 18, 2024 Category: Intensive Care Authors: Romain Jouffroy, Anne-C écile Vie and Benoît Vivien Tags: Matters Arising Source Type: research
Significance of critical closing pressures (starling resistors) in arterial circulation
(Source: Critical Care)
Source: Critical Care - April 18, 2024 Category: Intensive Care Authors: Michael R. Pinsky, M. Ignacio Monge Garc ía and Arnaldo Dubin Tags: Comment Source Type: research
Policy framework for the utilization of generative AI
(Source: Critical Care)
Source: Critical Care - April 18, 2024 Category: Intensive Care Authors: Kunming Cheng and Haiyang Wu Tags: Correspondence Source Type: research
Time-dependent effect of prone position in ARDS: considerations for future research
(Source: Critical Care)
Source: Critical Care - April 18, 2024 Category: Intensive Care Authors: Yuxian Wang and Ming Zhong Tags: Matters Arising Source Type: research
ACE inhibitors and angiotensin receptor blockers differentially alter the response to angiotensin II treatment in vasodilatory shock
Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARB) medications are widely prescribed. We sought to assess how pre-admission use of these medications might impact the respons... (Source: Critical Care)
Source: Critical Care - April 18, 2024 Category: Intensive Care Authors: Daniel E. Leisman, Damian R. Handisides, Laurence W. Busse, Mark C. Chappell, Lakhmir S. Chawla, Michael R. Filbin, Marcia B. Goldberg, Kealy R. Ham, Ashish K. Khanna, Marlies Ostermann, Michael T. McCurdy, Christopher D. Adams, Tony N. Hodges and Rinaldo Tags: Research Source Type: research
Impact of attaining aggressive vs. conservative PK/PD target on the clinical efficacy of beta-lactams for the treatment of Gram-negative infections in the critically ill patients: a systematic review and meta-analysis
To perform a systematic review with meta-analysis with the dual intent of assessing the impact of attaining aggressive vs. conservative beta-lactams PK/PD target on the clinical efficacy for treating Gram-nega... (Source: Critical Care)
Source: Critical Care - April 16, 2024 Category: Intensive Care Authors: Milo Gatti, Pier Giorgio Cojutti and Federico Pea Tags: Research Source Type: research
Contribution of electrical impedance tomography to personalize positive end-expiratory pressure under ECCO2R
Extracorporeal Carbon Dioxide Removal (ECCO2R) is used in acute respiratory distress syndrome (ARDS) patients to facilitate lung-protective ventilatory strategies. Electrical Impedance Tomography (EIT) allows ind... (Source: Critical Care)
Source: Critical Care - April 16, 2024 Category: Intensive Care Authors: Benjamin Pequignot, Alain Combes, Mickael Lescroart, Bruno Levy and Matthieu Koszutski Tags: Brief Report Source Type: research
Effect of intra-arrest transport, extracorporeal cardiopulmonary resuscitation and immediate invasive assessment in refractory out-of-hospital cardiac arrest: a long-term follow-up of the Prague OHCA trial
Randomized data evaluating the impact of the extracorporeal cardiopulmonary resuscitation (ECPR) approach on long-term clinical outcomes in patients with refractory out-of-hospital cardiac arrest (OHCA) are la... (Source: Critical Care)
Source: Critical Care - April 16, 2024 Category: Intensive Care Authors: Daniel Rob, Klaudia Farkasovska, Marketa Kreckova, Ondrej Smid, Petra Kavalkova, Jaromir Macoun, Michal Huptych, Petra Havrankova, Juraj Gallo, Jan Pudil, Milan Dusik, Stepan Havranek, Ales Linhart and Jan Belohlavek Tags: Research Source Type: research
Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis
The relationship between smoking and the risk of acute respiratory distress syndrome (ARDS) has been recognized, but the conclusions have been inconsistent. This systematic review and meta-analysis investigate... (Source: Critical Care)
Source: Critical Care - April 14, 2024 Category: Intensive Care Authors: Lujia Zhang, Jiahuan Xu, Yue Li, Fanqi Meng and Wei Wang Tags: Research Source Type: research
