Evaluation of the prognostic nutritional index (PNI) as a tool for assessing disease activity in rheumatoid arthritis patients
ConclusionThis study demonstrates that the simple and readily available PNI could serve as an independent predictor of disease activity in rheumatoid arthritis patients.Key Points•The relationship between disease activity and the prognostic nutritional index, which is a nutritional indicator, in rheumatoid arthritis patients was investigated.•It has been shown that there is a connection between low PNI and high disease activity.•It has been shown that PNI can be used to evaluate disease severity with a simple calculation. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
Revealing the changes in signaling pathways caused by tofacitinib in patients with rheumatoid arthritis through RNA sequencing and the correlation with clinical parameters
ConclusionsOur results highlighted the role of type I IFN, mainly including IFN α and IFN β, in the pathogenesis of RA and action for tofacitinib, and provided a new entry point for further elucidating the mechanism of morning stiffness.Key Points•Gene set IFN α and IFN β signaling was the most significantly down-regulated after tofacitinib treatment in RA patients.•Gene Oasl and Vgll3 were correlated with morning stiffness and significantly down-regulated due to the action of tofacitinib.•Type I IFN system was highlighted in the action of tofacitinib. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
How can clinicians enhance self-efficacy beliefs in osteoarthritis? An overview of systematic reviews with meta-analysis
AbstractThis overview of reviews aimed to synthesize the effectiveness of non-pharmacological approaches to enhance self-efficacy in people with osteoarthritis. The CINAHL, Embase, PsycINFO, PubMed, SPORTDiscus, and the Cochrane Library databases were searched from inception to December 2023. We considered systematic reviews with meta-analysis of randomized clinical trials evaluating any non-pharmacological intervention. We used AMSTAR 2 to assess the methodological quality of reviews. The overlap between reviews was calculated. We included eight systematic reviews with meta-analysis evaluating 30 different clinical trials...
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
Phenotypes of patients with systemic sclerosis in the Chinese Han population: a cluster analysis
ConclusionThe results of our cluster analysis study implied that limiting SSc patient subgroups to those based only on skin involvement might not capture the full heterogeneity of the disease. Organ damage and antibody profiles should be considered when identifying homogeneous patient groups with a specific prognosis.Key Points• Provides a new method of categorizing SSc patients.• Can better explain disease progression and guide subsequent treatment. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
A retrospective cohort study of Epstein-Barr virus infection status and systemic lupus erythematosus
ConclusionsPatients with SLE with lytic EBV infection have higher disease activity and take longer to achieve remission. Our study furthers our understanding of the relationship between SLE and EBV infection and may inform better treatment practices in the future. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
Efficacy and safety of tofacitinib for chronic plaque psoriasis and psoriatic arthritis: a systematic review and meta-analysis of randomized controlled trials
ConclusionsA comprehensive analysis revealed that tofacitinib has a positive effect on addressing skin and joint symptoms, as well as improving the quality of life for patients with chronic plaque psoriasis and psoriatic arthritis (PsA). However, the safety of the drug ’s long-term usage even requires further validation.Key Points• In 6 analyses involving a total of 1393 patients, tofacitinib exhibits positive effect on the treatment of both chronic plaque psoriasis and psoriatic arthritis (PsA).• Although dose-based subgroup analyses have demonstrated effectiveness. Some studies indicate that the 5-mg dose (twice da...
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
Association between enthesitis/dactylitis resolution and patient-reported outcomes in guselkumab-treated patients with psoriatic arthritis
ConclusionIn biologic-na ïve patients with active PsA treated with guselkumab, achieving ER or DR was associated with durable improvements in selected PROs, including those of high importance to patients.Trial registrationClinicalTrials.gov (https://clinicaltrials.gov) NCT03158285; Registered: May 16, 2017.Key Points•At week 100, 65% and 76% of guselkumab-treated patients achieved enthesitis and dactylitis resolution (ER/DR).•Achieving ER was associated with achieving DR and vice versa through the end of study.•Achieving ER or DR was associated with durable and meaningful improvements in selected patient-reported ou...
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
Identification of EPSTI1 as a new potential biomarker for SLE based on GEO database
ConclusionTogether,EPSTI1 was found to be a potential biomarker for SLE, closely related to T cell immune imbalance.Key Points• EPSTI1 expression was significantly increased in PBMCs of SLE patients.• EPSTI1 was positively correlated with disease activity and T cell activation- or differentiation-associated genes in SLE patients.• EPSTI1 might have a good diagnostic value for SLE. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
Comparison of the efficacy and safety of benzbromarone and febuxostat in gout and hyperuricemia: a systematic review and meta-analysis
ConclusionThis study highlights the superiority of benzbromarone in rapidly reducing SUA and inhibiting inflammation. Febuxostat shows comparable effects on liver and kidney function after long-term use. These findings provide valuable insights for clinicians and patients in drug selection.Key Points• Benzbromarone stands out as a highly effective treatment for hyperuricemia and gout, offering rapid reduction of serum uric acid levels and potent anti-inflammatory effects.• When it comes to long-term use, febuxostat demonstrates comparable effects on liver and kidney function. This provides reassurance for patients who ...
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
Raman spectroscopic analysis of joint capsule calcification of the fingers
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
Letter to the Editor: “Development and validation of equations for conversion from DAS28ESR and DAS28CRP to the SDAI in patients with rheumatoid arthritis”
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
Respiratory infection risk in primary Sj ögren’s syndrome complicated with interstitial lung disease: a retrospective study
(Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 16, 2024 Category: Rheumatology Source Type: research
How can clinicians enhance self-efficacy beliefs in osteoarthritis? An overview of systematic reviews with meta-analysis
AbstractThis overview of reviews aimed to synthesize the effectiveness of non-pharmacological approaches to enhance self-efficacy in people with osteoarthritis. The CINAHL, Embase, PsycINFO, PubMed, SPORTDiscus, and the Cochrane Library databases were searched from inception to December 2023. We considered systematic reviews with meta-analysis of randomized clinical trials evaluating any non-pharmacological intervention. We used AMSTAR 2 to assess the methodological quality of reviews. The overlap between reviews was calculated. We included eight systematic reviews with meta-analysis evaluating 30 different clinical trials...
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
A retrospective cohort study of Epstein-Barr virus infection status and systemic lupus erythematosus
ConclusionsPatients with SLE with lytic EBV infection have higher disease activity and take longer to achieve remission. Our study furthers our understanding of the relationship between SLE and EBV infection and may inform better treatment practices in the future. (Source: Clinical Rheumatology)
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
Efficacy and safety of tofacitinib for chronic plaque psoriasis and psoriatic arthritis: a systematic review and meta-analysis of randomized controlled trials
ConclusionsA comprehensive analysis revealed that tofacitinib has a positive effect on addressing skin and joint symptoms, as well as improving the quality of life for patients with chronic plaque psoriasis and psoriatic arthritis (PsA). However, the safety of the drug ’s long-term usage even requires further validation.Key Points• In 6 analyses involving a total of 1393 patients, tofacitinib exhibits positive effect on the treatment of both chronic plaque psoriasis and psoriatic arthritis (PsA).• Although dose-based subgroup analyses have demonstrated effectiveness. Some studies indicate that the 5-mg dose (twice da...
Source: Clinical Rheumatology - April 15, 2024 Category: Rheumatology Source Type: research
