Avoidable childhood blindness in a high-income country: findings from the British Childhood Visual Impairment and Blindness Study 2
Conclusion
Despite significant progress in the past decades in high-income countries, there remains a need to be vigilant about implementing preventive strategies and treatments. Attention to disorders that are currently neither preventable nor treatable remains a priority in these settings and will become increasingly important in lower-income and middle-income countries undergoing economic transition. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Solebo, A. L., Teoh, L., Sargent, J., Rahi, J. S., on behalf of the British Childhood Visual Impairment and Blindness Study Interest Group Tags: Editor's choice Original articles - Clinical science Source Type: research
Immediate sequential bilateral cataract surgery: a 13-year real-life report of 56 700 cataract operations
Conclusion
The proportion of patients undergoing ISBCS increased from 4.2% in 2008 to 46% in 2020. No endophthalmitis were found to be associated with ISBCS. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Hujanen, P., Vaajanen, A., Felin, T., Lehtonen, E., Syvänen, U., Huhtala, H., Helminen, M., Sintonen, H., Tuulonen, A., Uusitalo-Järvinen, H. Tags: Open access Original articles - Clinical science Source Type: research
Comparison of mini-simple limbal epithelial transplantation and conjunctival-limbal autograft for the treatment of primary pterygium: a randomised controlled trial
Conclusion
The findings of this study suggest that mini-SLET has a higher recurrence rate and provides no advantage over CLAu in the treatment of primary pterygium. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Oliva-Bienzobas, V., Nava-Castaneda, A., Jimenez-Corona, A., Kahuam-Lopez, N., Ramirez-Miranda, A., Navas, A., Graue-Hernandez, E. O. Tags: Open access Original articles - Clinical science Source Type: research
Risk factors for corneal ulcers: a population-based matched case-control study in Nepal
Conclusion
We found ocular injury, manual labour and lower education to be strongly associated with the development of corneal ulcer. Given the persistent burden of corneal blindness in this area, prevention efforts could target efforts to increase access to care in areas where these factors are common. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Byanju, R., Kandel, R. P., Poudyal, B., Bhandari, S., Ligal, A., Pradhan, S., Gautam, M., Shrestha, P., Sah, R. K., Gonzales, J. A., Porco, T. C., Whitcher, J. P., Srinivasan, M., Upadhyay, M. P., Lietman, T. M., Keenan, J. D., O'Brien, K. S., The Village Tags: Original articles - Clinical science Source Type: research
Hypotony in uveitis: an overview of medical and surgical management
Hypotony is a well-recognised, sight-threatening complication of uveitis. It can also be the final common endpoint for a multitude of disease entities. Multiple mechanisms underlie hypotony, and meticulous clinical history alongside ocular phenotyping is necessary for choosing the best intervention and therapeutic management. In this narrative review, a comprehensive overview of medical and surgical treatment options for the management of non-surgically induced hypotony is provided. Management of ocular hypotony relies on the knowledge of the aetiology and mechanisms involved. An understanding of disease trajectory is vita...
Source: British Journal of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Testi, I., Calcagni, A., Barton, K., Gooch, J., Petrushkin, H. Tags: Review Source Type: research
Diabetic retinopathy screening: does one size fit all?
Health policy is constantly striving to release capacity in overstretched health services, or to improve effectiveness, efficiency and patient experience, while maintaining clinical safety. However, policy implementation may also introduce unintended consequences. This is elegantly highlighted in the paper by Olvera-Barrios et al1 reporting a large retrospective study on the differential impact of extended diabetic eye screening intervals among persons with diabetes, considered to be at low risk of sight loss. Understanding disparities in health (inequalities and variations in healthcare) and addressing their underlying fa...
Source: British Journal of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Desai, P., De Silva, S. R. Tags: Press releases Commentaries Source Type: research
At a glance
Risk factors for corneal ulcers: a population-based matched case-control study in Nepal (see page 1771) This population-based matched case-control study in Nepal evaluated risk factors for corneal ulcer. We found that ocular injury, manual labour, and lower education were associated with the development of corneal ulceration in this setting. Comparison of mini-simple limbal epithelial transplantation and conjunctival–limbal autograft for the treatment of primary pterygium: a randomised controlled trial (see page 1776) The findings of this double-masked parallel randomised controlled trial comparing mini-simple limbal...
Source: British Journal of Ophthalmology - November 22, 2023 Category: Opthalmology Authors: Larkin, F. Tags: Open access Highlights from this issue Source Type: research
Correlation of ex vivo and in vivo confocal microscopy imaging of Acanthamoeba
Conclusion
EVCM demonstrated the various forms of Acanthamoeba cyst and trophozoites can be used as a reference to identify similar structures on IVCM. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 20, 2023 Category: Opthalmology Authors: Alantary, N., Heaselgrave, W., Hau, S. Tags: Original articles - Laboratory science Source Type: research
Heterozygous variants c.781G>A and c.1066dup of serine protease 56 cause familial nanophthalmos by impairing serine-type endopeptidase activity
Conclusion
The c.781G>A and c.1066dup variants of the PRSS56 gene might negatively affect protein structures, subcellular localisation, serine-type endopeptidase activity and cellular migratory ability. Together, these changes could lead to the development of nanophthalmos. This study identifies the PRSS56 gene as a potential target for nanophthalmos diagnosis and treatment. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 20, 2023 Category: Opthalmology Authors: Wu, W., Xu, J., Yin, H., Fu, C., Yao, K., Chen, X. Tags: Original articles - Laboratory science Source Type: research
Succinic acid exacerbates experimental autoimmune uveitis by stimulating neutrophil extracellular traps formation via SUCNR1 receptor
Conclusions
Succinic acid could worsen EAU induced by IRBP in mice. This effect was possibly mediated by its upregulation on NETs generation and frequencies of Th1/Th17 cells in affiliation with increased production of IFN-/IL-17A through succinic acid-SUCNR1 axis. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 20, 2023 Category: Opthalmology Authors: Li, H., Tan, H., Liu, Z., Pan, S., Tan, S., Zhu, Y., Wang, Q., Su, G., Zhou, C., Cao, Q., Yang, P. Tags: Original articles - Laboratory science Source Type: research
Intraretinal pigmented cells in retinal degenerative disease
Conclusions
Our findings suggest that RPE cells invading the retina dedifferentiate (losing classic RPE markers) and can be pigmented or unpigmented. Therefore, the number of RPE cells invading the retina in retinal degenerative disease may be underappreciated by funduscopy. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 20, 2023 Category: Opthalmology Authors: Yasvoina, M., Yang, Q., Woods, S. M., Heeren, T., Comer, G. M., A. Egan, C., Fruttiger, M. Tags: Original articles - Laboratory science Source Type: research
13q32.1 as a candidate region for physiological anisocoria
Conclusion
The very specific region associated with anisocoria is one where microdeletions (or microduplications) are known to lead to abnormal development of pupil dilator muscle and hence to the autosomal dominant condition of microcoria. It is possible that alterations at 13q32.1 act by altering the expression of SOX21, which encodes a nuclear transcription factor. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 20, 2023 Category: Opthalmology Authors: Bosten, J. M., Lawrance-Owen, A. J., Bargary, G., Goodbourn, P. T., Mollon, J. D. Tags: Original articles - Laboratory science Source Type: research
Ensemble neural network model for detecting thyroid eye disease using external photographs
Conclusions
The deep learning classifier is a novel approach to identify TED and is a first step in the development of tools to improve diagnostic accuracy and lower barriers to specialist evaluation. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 20, 2023 Category: Opthalmology Authors: Karlin, J., Gai, L., LaPierre, N., Danesh, K., Farajzadeh, J., Palileo, B., Taraszka, K., Zheng, J., Wang, W., Eskin, E., Rootman, D. Tags: Original articles - Clinical science Source Type: research
Non-invasive intracranial pressure estimation using ultrasonographic measurement of area of optic nerve subarachnoid space
Conclusion
Measurement of the ONSASA using ultrasonography can serve as a practical method for rapid and non-invasive quantification for evaluating ICP through an accurate mathematical formula with the BMI and MABP considered as contributing parameters.
Trial registration number
The study was registered in the Chinese Clinical Trial Registry (Study no ChiCTR2100045274). (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 20, 2023 Category: Opthalmology Authors: Zhang, Y., Cao, K., Pang, R., Wang, N., Qu, X., Kang, J., Wang, N., Liu, H. Tags: Original articles - Clinical science Source Type: research
Control of myopia using diffusion optics spectacle lenses: 12-month results of a randomised controlled, efficacy and safety study (CYPRESS)
Conclusion
12-month results from this ongoing trial demonstrate the safety and effectiveness of DOT spectacles for reducing myopic progression. (Source: British Journal of Ophthalmology)
Source: British Journal of Ophthalmology - October 20, 2023 Category: Opthalmology Authors: Rappon, J., Chung, C., Young, G., Hunt, C., Neitz, J., Neitz, M., Chalberg, T. Tags: Open access Original articles - Clinical science Source Type: research
