Blood Purification with oXiris © in Critically Ill Children with Vasoplegic Shock
Conclusion: Hemofiltration and extracorporeal blood purification with oXiris © can be used in pediatric patients with vasoplegic shock with rapid improvement in hemodynamics in selected patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 27, 2023 Category: Hematology Source Type: research
Enhancing Immune Protection in Hemodialysis Patients: Role of the Polymethyl Methacrylate Membrane
End-stage renal disease (ESRD) is characterized by deep disorders in both innate and adaptive immune systems that imply unbalance deactivation and immunosuppression. The central, widely recognized factors responsible for this immune dysregulation are uremia, uremic toxin retention, hemodialysis membrane biocompatibility, and related cardiovascular complications. Recently, several studies strengthened the concept that dialysis membranes are not considered as a simple diffusive/adsorptive device but as a platform to personalize a dialysis approach to improve the quality of life of ESRD patients. Therefore, understanding of t...
Source: Blood Purification - April 19, 2023 Category: Hematology Source Type: research
Continuous Renal Replacement Therapy during Extracorporeal Membrane Oxygenation: Circuit Haemodynamics and Circuit Failure
Conclusion: CRRT circuits used in conjunction with ECMO have a longer circuit life than usual CRRT despite exposure to higher circuit pressures. Markedly elevated access pressures, however, may predict early CRRT circuit failure during ECMO, possibly via progressive membrane thrombosis as evidenced by increased transfilter pressure gradients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 19, 2023 Category: Hematology Source Type: research
Impact of Continuous Renal Replacement Therapy Initiation on Urine Output and Fluid Balance: A Multicenter Study
Conclusion: Commencement of CRRT was associated with a significant decrease in UO that could not be explained by extracorporeal fluid removal.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 18, 2023 Category: Hematology Source Type: research
Better Anti-Spike IgG Antibody Response to SARS-CoV-2 Vaccine in Patients on Haemodiafiltration than on Haemodialysis
Conclusion: This is the first study to show that on-line HDF preserves the antibody response better than high-flux HD after vaccination with SARS-CoV-2 vaccine. Treatment strategies that sustain the vaccine response are essential to apply in this vulnerable group of patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 14, 2023 Category: Hematology Source Type: research
Efficacy of Double Membrane Filtration Immunoadsorption in Severe C1q-Binding Donor-Specific Antibody-Positive Acute Humoral Kidney Allograft Rejection: A Case Series
Conclusions: Our data support the consideration of DFPP + IA as a rescue treatment option in early, severe, high-risk ABMR cases in which other treatments failed.Blood Purif (Source: Blood Purification)
Source: Blood Purification - April 12, 2023 Category: Hematology Source Type: research
Examination of the Effect of Switching Dialysis Membranes on the Immune Response to Influenza Virus Vaccination in Hemodialysis Patients
Conclusion: The responsiveness to vaccination against influenza virus was lower in HD patients compared with HVs. Changing the dialysis membrane from PS to PMMA appeared to affect the response to vaccination in HD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 30, 2023 Category: Hematology Source Type: research
Changes in QT Interval in Maintenance Hemodialysis Patients: Pre-Dialysis, One Hour after Initiation of Dialysis, and Post-Dialysis
Conclusions: There was an increased risk of prolonged QT interval in MHD patients regardless of the absence of the previous abnormal QT interval. Notably, this risk increased rapidly 1 h after the initiation of dialysis.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 30, 2023 Category: Hematology Source Type: research
Evaluation of the Effect of the PMMA Dialysis Membrane on the Level of Inflammation in Patients on Hemodialysis
Conclusion: In our study, we demonstrated for the first time a significant reduction in the level of inflammation in patients on standard hemodialysis in routine practice due to the use of PMMA membranes.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 29, 2023 Category: Hematology Source Type: research
Immunomodulation Effect of Regional Citrate Anticoagulation in Acute Kidney Injury Requiring Renal Replacement Therapy
Conclusions: RCA may have the potential to mitigate the inflammatory response by decreasing CD11b expression of neutrophil and improve fibrinolysis activity through a reduction of PAI-1 levels. Larger clinical trials are warranted to test this immunomodulation effect of RCA.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 14, 2023 Category: Hematology Source Type: research
Hypertriglyceridemia as a Cause of Continuous Renal Replacement Therapy Circuit Clotting: A Case Series
Conclusion: Due to the propensity of propofol use for critically ill patients in intensive care units, and the rather common occurrence of CRRT circuit clotting, hypertriglyceridemia may be underappreciated and undiagnosed. The exact pathophysiology behind hypertriglyceridemia-induced CRRT clotting has not been fully elucidated, although there are some hypotheses which include fibrin and fat droplet deposition (identified after electron microscopic examination of the hemofilter), increased blood viscosity, and development of a procoagulant state. Premature clotting poses a multitude of problems including inadequate treatme...
Source: Blood Purification - March 10, 2023 Category: Hematology Source Type: research
Prediction of Intradialytic Blood Pressure Variation Based on Big Data
In this study, dialysis equipment connected to the Vital Info Portal gateway collected HD parameters that were linked to demographic data stored in the hospital information system. There were 3 types of patients: training, test, and new. A multiple linear regression model was built using the training group with SBP change as the dependent variable and dialysis parameters as the independent variables. We tested the model ’s performance on test and new patient groups using coverage rates with different thresholds. The model’s performance was visualized using a web-based interactive system.Results: A total of 542,424 BP r...
Source: Blood Purification - March 8, 2023 Category: Hematology Source Type: research
Clearance of NT-proBNP and Procalcitonin during Continuous Venovenous Hemodialysis with the Medium Cutoff Filter in Patients with Rhabdomyolysis-Associated Early Acute Kidney Injury
Conclusion: CVVHD with EMiC2 filter showed low clearances for NT-proBNP and procalcitonin. CVVHD did not significantly affect the serum levels of these biomarkers, which could be adopted in the clinical management of early CVVHD patients.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 7, 2023 Category: Hematology Source Type: research
Workshop Purification Therapies – From Research to Clinical Evidence Milan, Italy, September 30th – October 1st, 2022
Blood Purif 2022;51(suppl 3):I –II (Source: Blood Purification)
Source: Blood Purification - March 3, 2023 Category: Hematology Source Type: research
Ceftaroline and Avibactam Removal by Continuous Renal Replacement Therapies: An in vitro Study
Discussion: Avibactam and ceftaroline are extensively removed through the polysulfone membrane, and a dose adjustment may be recommended for patients under CRRT to ensure pharmacodynamic target achievement.Blood Purif (Source: Blood Purification)
Source: Blood Purification - March 1, 2023 Category: Hematology Source Type: research
