Autophagy cooperates with PDGFRA to support oncogenic growth signaling
Autophagy. 2024 Apr 18:1-2. doi: 10.1080/15548627.2024.2338572. Online ahead of print.ABSTRACTMacroautophagy (referred to as autophagy hereafter) is a highly conserved catabolic process which sequesters intracellular substrates for lysosomal degradation. Autophagy-related proteins have been shown to be involved in various aspects of tumor development by engaging with multiple cellular substrates. We recently uncovered a novel role for autophagy in regulating the signaling and levels of PDGFRA, a receptor tyrosine kinase amplified in several cancers. We discovered that PDGFRA can be targeted to autophagic degradation by bin...
Source: Autophagy - April 18, 2024 Category: Cytology Authors: Joanne E Simpson Noor Gammoh Source Type: research
Toxic gain-of-function mechanisms in < em > C9orf72 < /em > ALS-FTD neurons drive autophagy and lysosome dysfunction
Autophagy. 2024 Apr 18:1-3. doi: 10.1080/15548627.2024.2340415. Online ahead of print.ABSTRACTHexanucleotide repeat expansions in the C9orf72 gene are the primary genetic cause for both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two related neurodegenerative diseases. Significant advances in the elucidation of the disease mechanisms responsible for C9orf72 ALS-FTD have revealed both a toxic gain-of-function and a loss-of-function mechanism as possible underlying disease cause. As the differential contribution of both gain and loss of function in C9orf72 ALS-FTD pathogenesis remains debated, we i...
Source: Autophagy - April 14, 2024 Category: Cytology Authors: Jimmy Beckers Philip Van Damme Source Type: research
Impaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms
Autophagy. 2024 Apr 18:1-17. doi: 10.1080/15548627.2024.2338574. Online ahead of print.ABSTRACTCrohn disease (CD) is an inflammatory bowel disease whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD is associated with single-nucleotide polymorphisms affecting several genes involved in macroautophagy/autophagy, the catabolic process that ensures the degradation and recycling of cytosolic components and microorganisms. In a clinical translation perspective, monitoring the autophagic activity of CD patients will require some knowledge on the intr...
Source: Autophagy - April 14, 2024 Category: Cytology Authors: Ga ëlle Quiniou Leslie Andromaque R émi Duclaux-Loras Oc éane Dinet Ornella Cervantes Mallorie Verdet Camille Meunier Gilles Boschetti Christophe Viret St éphane Nancey Mathias Faure Aurore Rozi ères Source Type: research
Toxic gain-of-function mechanisms in < em > C9orf72 < /em > ALS-FTD neurons drive autophagy and lysosome dysfunction
Autophagy. 2024 Apr 14. doi: 10.1080/15548627.2024.2340415. Online ahead of print.ABSTRACTHexanucleotide repeat expansions in the C9orf72 gene are the primary genetic cause for both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two related neurodegenerative diseases. Significant advances in the elucidation of the disease mechanisms responsible for C9orf72 ALS-FTD have revealed both a toxic gain-of-function and a loss-of-function mechanism as possible underlying disease cause. As the differential contribution of both gain and loss of function in C9orf72 ALS-FTD pathogenesis remains debated, we inves...
Source: Autophagy - April 14, 2024 Category: Cytology Authors: Jimmy Beckers Philip Van Damme Source Type: research
Impaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms
Autophagy. 2024 Apr 14. doi: 10.1080/15548627.2024.2338574. Online ahead of print.ABSTRACTCrohn disease (CD) is an inflammatory bowel disease whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD is associated with single-nucleotide polymorphisms affecting several genes involved in macroautophagy/autophagy, the catabolic process that ensures the degradation and recycling of cytosolic components and microorganisms. In a clinical translation perspective, monitoring the autophagic activity of CD patients will require some knowledge on the intrinsic...
Source: Autophagy - April 14, 2024 Category: Cytology Authors: Ga ëlle Quiniou Leslie Andromaque R émi Duclaux-Loras Oc éane Dinet Ornella Cervantes Mallorie Verdet Camille Meunier Gilles Boschetti Christophe Viret St éphane Nancey Mathias Faure Aurore Rozi ères Source Type: research
Toxic gain-of-function mechanisms in < em > C9orf72 < /em > ALS-FTD neurons drive autophagy and lysosome dysfunction
Autophagy. 2024 Apr 14. doi: 10.1080/15548627.2024.2340415. Online ahead of print.ABSTRACTHexanucleotide repeat expansions in the C9orf72 gene are the primary genetic cause for both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), two related neurodegenerative diseases. Significant advances in the elucidation of the disease mechanisms responsible for C9orf72 ALS-FTD have revealed both a toxic gain-of-function and a loss-of-function mechanism as possible underlying disease cause. As the differential contribution of both gain and loss of function in C9orf72 ALS-FTD pathogenesis remains debated, we inves...
Source: Autophagy - April 14, 2024 Category: Cytology Authors: Jimmy Beckers Philip Van Damme Source Type: research
Impaired reprogramming of the autophagy flux in maturing dendritic cells from crohn disease patients with core autophagy gene-related polymorphisms
Autophagy. 2024 Apr 14. doi: 10.1080/15548627.2024.2338574. Online ahead of print.ABSTRACTCrohn disease (CD) is an inflammatory bowel disease whose pathogenesis involves inappropriate immune responses toward gut microbiota on genetically predisposed backgrounds. Notably, CD is associated with single-nucleotide polymorphisms affecting several genes involved in macroautophagy/autophagy, the catabolic process that ensures the degradation and recycling of cytosolic components and microorganisms. In a clinical translation perspective, monitoring the autophagic activity of CD patients will require some knowledge on the intrinsic...
Source: Autophagy - April 14, 2024 Category: Cytology Authors: Ga ëlle Quiniou Leslie Andromaque R émi Duclaux-Loras Oc éane Dinet Ornella Cervantes Mallorie Verdet Camille Meunier Gilles Boschetti Christophe Viret St éphane Nancey Mathias Faure Aurore Rozi ères Source Type: research
Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies
Autophagy. 2024 Apr 10:1-2. doi: 10.1080/15548627.2024.2340413. Online ahead of print.ABSTRACTSQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets entirely colocalize with P-body markers, and these stress-induced SQSTM1 droplets contain mRNAs. We thus determined that under certain stress conditions, autophagic SQSTM1 droplets are converted to a type of enlarged P-bodies, designated SQSTM1/p62-dependent P-bodies (pd-PBs). Stress-enhanced SQSTM1 droplet formation drives the nucleation ...
Source: Autophagy - April 11, 2024 Category: Cytology Authors: Evelina Valionyte Elizabeth R Barrow Chris R Baxter Sharon Herath Shouqing Luo Source Type: research
Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies
Autophagy. 2024 Apr 10:1-2. doi: 10.1080/15548627.2024.2340413. Online ahead of print.ABSTRACTSQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets entirely colocalize with P-body markers, and these stress-induced SQSTM1 droplets contain mRNAs. We thus determined that under certain stress conditions, autophagic SQSTM1 droplets are converted to a type of enlarged P-bodies, designated SQSTM1/p62-dependent P-bodies (pd-PBs). Stress-enhanced SQSTM1 droplet formation drives the nucleation ...
Source: Autophagy - April 11, 2024 Category: Cytology Authors: Evelina Valionyte Elizabeth R Barrow Chris R Baxter Sharon Herath Shouqing Luo Source Type: research
Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies
Autophagy. 2024 Apr 10:1-2. doi: 10.1080/15548627.2024.2340413. Online ahead of print.ABSTRACTSQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets entirely colocalize with P-body markers, and these stress-induced SQSTM1 droplets contain mRNAs. We thus determined that under certain stress conditions, autophagic SQSTM1 droplets are converted to a type of enlarged P-bodies, designated SQSTM1/p62-dependent P-bodies (pd-PBs). Stress-enhanced SQSTM1 droplet formation drives the nucleation ...
Source: Autophagy - April 11, 2024 Category: Cytology Authors: Evelina Valionyte Elizabeth R Barrow Chris R Baxter Sharon Herath Shouqing Luo Source Type: research
Transformation of autophagic SQSTM1 droplets to SQSTM1-dependent P-bodies
Autophagy. 2024 Apr 10:1-2. doi: 10.1080/15548627.2024.2340413. Online ahead of print.ABSTRACTSQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets entirely colocalize with P-body markers, and these stress-induced SQSTM1 droplets contain mRNAs. We thus determined that under certain stress conditions, autophagic SQSTM1 droplets are converted to a type of enlarged P-bodies, designated SQSTM1/p62-dependent P-bodies (pd-PBs). Stress-enhanced SQSTM1 droplet formation drives the nucleation ...
Source: Autophagy - April 11, 2024 Category: Cytology Authors: Evelina Valionyte Elizabeth R Barrow Chris R Baxter Sharon Herath Shouqing Luo Source Type: research
MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX
Autophagy. 2024 Apr 10. doi: 10.1080/15548627.2024.2340399. Online ahead of print.ABSTRACTMutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy. Upon mitochondrial import failure, PINK1 accumulates in association with the translocase of outer mitochondrial membrane (TOMM). However, the molecular basis of this PINK1 accumulation on the TOMM complex remain elusive. We recently demonstrated that TIMM23 (translocase of th...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Mohamed A Eldeeb Armaan Fallahi Andrea Soumbasis Andrew N Bayne Jean-Fran çois Trempe Edward A Fon Source Type: research
Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response
Autophagy. 2024 Apr 10. doi: 10.1080/15548627.2024.2340420. Online ahead of print.ABSTRACTNon-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic diarrhea virus (PEDV), causes high mortality in neonatal piglets worldwide. To determine the biological role of nsp2, we generated a PEDV mutant containing a complete nsp2 deletion (rPEDV-Δnsp2) from a highly pathogenic strain by reverse genetics, showing that nsp2 was dispensable for PEDV infection, while its deficiency reduced viral replication in vitro. In...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Yajuan Jiao Pengwei Zhao Ling-Dong Xu Jia-Qi Yu Hou-Li Cai Chong Zhang Chao Tong Yong-Le Yang Pinglong Xu Qiming Sun Ning Chen Bin Wang Yao-Wei Huang Source Type: research
Massive ER protein disposal by reticulophagy receptors and selective disposal by TOLLIP
Autophagy. 2024 Apr 11:1-2. doi: 10.1080/15548627.2024.2340417. Online ahead of print.ABSTRACTProteostasis of the endoplasmic reticulum (ER) is maintained by coordinated action of two major catabolic pathways: proteasome-dependent ER-associated degradation (ERAD) and less characterized lysosomal pathways. Recent studies on ER-specific autophagy (termed "reticulophagy") have highlighted the importance of lysosomes for ER proteostasis. Key to this process are proteins termed reticulophagy receptors that connect ER fragments and Atg8-family proteins, facilitating the lysosomal degradation of both native and aberrant ER protei...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Yuki Hayashi Hidenori Ichijo Source Type: research
MITOCHONDRIAL IMPORT STRESS and PINK1-MEDIATED MITOPHAGY: THE ROLE of the PINK1-TOMM-TIMM23 SUPERCOMPLEX
Autophagy. 2024 Apr 10. doi: 10.1080/15548627.2024.2340399. Online ahead of print.ABSTRACTMutations in the PINK1 kinase cause Parkinson disease (PD) through physiological processes that are not yet fully elucidated. PINK1 kinase accumulates selectively on damaged mitochondria, where it recruits the E3 ubiquitin ligase PRKN/Parkin to mediate mitophagy. Upon mitochondrial import failure, PINK1 accumulates in association with the translocase of outer mitochondrial membrane (TOMM). However, the molecular basis of this PINK1 accumulation on the TOMM complex remain elusive. We recently demonstrated that TIMM23 (translocase of th...
Source: Autophagy - April 10, 2024 Category: Cytology Authors: Mohamed A Eldeeb Armaan Fallahi Andrea Soumbasis Andrew N Bayne Jean-Fran çois Trempe Edward A Fon Source Type: research
