Transcriptional Regulation of CD4+ T Cell Differentiation in Experimentally Induced Arthritis and Rheumatoid Arthritis
Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronic inflammation of the joint synovium and infiltration by activated inflammatory cells. CD4+ T cells form a large proportion of the inflammatory cells invading the synovial tissue, and are involved in the RA pathologic process. In general, CD4+ T cells differentiate into various T helper cell subsets and acquire the functional properties to respond to specific pathogens, and also mediate some autoimmune disorders such as RA. Because the differentiation of T helper cell subsets is determined by the expression of specific transcription factors in respo...
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Yuya Kondo, Masahiro Yokosawa, Shunta Kaneko, Kotona Furuyama, Seiji Segawa, Hiroto Tsuboi, Isao Matsumoto, Takayuki Sumida Tags: Review Source Type: research
Lupus Erythematosus cell
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Armin Rashidi, Stephen I. Fisher Tags: Clinical Image Source Type: research
Is the T Follicular Regulatory / T Follicular Helper Cell Ratio in Blood a Biomarker for Ectopic Lymphoid Structure Formation in Sj ögren's Syndrome?
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Gwenny M. Verstappen, Uzma Nakshbandi, Esther Mossel, Erlin A. Haacke, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frans G.M. Kroese Tags: Letter to the Editor Source Type: research
Modulation of inflammatory arthritis by gut microbiota through mucosal inflammation and autoantibody generation
ConclusionsThese data support a model in which intestinal dysbiosis triggers mucosal immune responses that stimulate T and B cells that are key for the development of inflammatory arthritis.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Widian K. Jubair, Jason D. Hendrickson, Erin L. Severs, Hanna M. Schulz, Sumitra Adhikari, Diana Ir, Jose Pagan, Robert Anthony, Charles E. Robertson, Daniel N. Frank, Nirmal K. Banda, Kristine A. Kuhn Tags: Full Length Source Type: research
Two independent studies show blood follicular T cell subsets allow the stratification of Sj ögren's syndrome patients
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Valter R Fonseca, Vasco C Rom ão, Ana Agua‐Doce, João Eurico Fonseca, Luis Graca Tags: Reply to Letter to the Editor Source Type: research
Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids
ConclusionThe GC gene signature identified in this study represents a pharmacodynamic marker of GC exposure.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: Yanhua Hu, Julie A. Carman, Deborah Holloway, Selena Kansal, Li Fan, Christine Goldstine, Deborah Lee, John E. Somerville, Robert Latek, Robert Townsend, Alyssa Johnsen, Sean Connolly, Somnath Bandyopadhyay, Nancy Shadick, Michael E. Weinblatt, Richard Fu Tags: Full Length Source Type: research
Common Language Description of the Term Rheumatic and Musculoskeletal Diseases (RMDs) for Use in Communication With the Lay Public, Healthcare Providers, and Other Stakeholders Endorsed by the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR)
A European League Against Rheumatism–American College of Rheumatology working group consisting of practicing and academic rheumatologists, a rheumatology researcher, and a patient representative created a succinct general statement describing rheumatic and musculoskeletal diseases (RMDs) in adults and children in language that can be used in conversations with the lay public, media, healthcare providers, and other stakeholders. Based on the literature review, several elements were deemed important for inclusion in the description of RMDs. First, RMDs encompass many different diseases that can affect individuals at any ag...
Source: Arthritis and Rheumatism - March 13, 2018 Category: Rheumatology Authors: D ésirée Heijde, David I. Daikh, Neil Betteridge, Gerd R. Burmester, Afton L. Hassett, Eric L. Matteson, Ronald Vollenhoven, Sharad Lakhanpal Tags: Special Article Source Type: research
Selective Activation of Tumor Necrosis Factor Receptor II Induces Antiinflammatory Responses and Alleviates Experimental Arthritis
ConclusionOur findings support the use of TNFRII‐selective therapeutics as an effective approach to the treatment of arthritic disease and possibly other inflammatory and autoimmune diseases. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 11, 2018 Category: Rheumatology Authors: Roman Fischer, Marcel Proske, Ma ëlle Duffey, Hubert Stangl, George F. Martinez, Nathalie Peters, Alexandra Kraske, Rainer H. Straub, John R. Bethea, Roland E. Kontermann, Klaus Pfizenmaier Tags: Original Article Source Type: research
Comments on the “2017 Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups”. Points of concern
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Santos Casta ñeda, Lorenzo Cavagna, Miguel A. González‐Gay, Tags: Letter to the Editor Source Type: research
An ASAS ‐Positive MRI of the Sacroiliac Joints can also Occur in Healthy Individuals, Runners and Women with Postpartum Back Pain
ConclusionA substantial proportion of healthy individuals without current/past back pain has a positive MRI‐SI according to the ASAS definition. Deep (extensive) BME lesions are exclusively found in axSpA patients.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Janneke de Winter, Manouk de Hooge, Marleen van de Sande, Henri ëtte de Jong, Lonneke van Hoeven, Anoek de Koning, Inger Jorid Berg, Roberta Ramonda, Dominique Baeten, Désirée van der Heijde, Angelique Weel, Robert Landewé Tags: Full Length Source Type: research
Reply to Comments on the “Frequency of Chronic Joint Pain following Chikungunya Infection: A Colombian Cohort Study”, the Brazilian Experience
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Aileen Y. Chang, Liliana Encinales, Jeffrey M. Bethony, Gary L. Simon Tags: Reply to Letter to the Editor Source Type: research
Response to Comments on the “2017 EULAR/ACR Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups”. Points of concern
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Anna Tj ärnlund, Matteo Bottai, Ingrid E. Lundberg Tags: Reply to Letter to the Editor Source Type: research
Comments on the article “Frequency of Chronic Joint Pain following Chikungunya Infection: A Colombian Cohort Study”, the Brazilian Experience
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Roberto Mogami, Mirhelen M. De Abreu, Flavio Sztajnbock, Ana C. B. Koifman, Andr é de A Vieira, Rodrigo S. Torezani, Yêdda de F. B.Chagas, João L. P. Vaz Tags: Letter to the Editor Source Type: research
Allopurinol Dose Escalation and Mortality among Patients with Gout: A National Propensity ‐Matched Cohort Study
ConclusionThis is the largest study of allopurinol's effect on mortality and the first to use a rigorous active‐comparator design. Dose escalation was associated with a small (<10%) increase in all‐cause mortality, showing that allopurinol dose escalation is unlikely to improve survival as currently prescribed in real life practice characterized by limited dose increases.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Brian W Coburn, Kaleb Michaud, Debra A Bergman, Ted R Mikuls Tags: Full Length Source Type: research
Female reproductive and hormonal factors and incidence of primary total knee arthroplasty due to osteoarthritis
ConclusionsReproductive and hormonal factors were associated with knee osteoarthritis risk. These associations remained significant in normal weight women at early reproductive age and non‐obese women at midlife. Further work is needed to understand the complex effect of these factors on knee osteoarthritis.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Sultana Monira Hussain, Yuanyuan Wang, Graham G. Giles, Stephen Graves, Anita E. Wluka, Flavia M. Cicuttini Tags: Full Length Source Type: research
