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Carlos Américo Paiva Gonçalves Filho
ABSTRACT This review is intended to describe the therapeutic approaches for corneal blindness, detailing the steps and elements involved in corneal wound healing. It also presents the limitations of the actual surgical and pharmacological strategies used to restore and maintain corneal transparency in terms of long-term survival and geographic coverage. In addition, we critically review the perspectives of anabolic agents, including vitamin A, hormones, growth factors, and novel promitotic and anti-inflammatory modulators, to assist corneal wound healing. We discuss the studies involving nanotechnology, gene therapy, and t...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Fluorofenidone inhibits the epithelial-mesenchymal transition in human lens epithelial cell line FHL 124: a promising therapeutic strategy against posterior capsular opacification
ABSTRACT This review is intended to describe the therapeutic approaches for corneal blindness, detailing the steps and elements involved in corneal wound healing. It also presents the limitations of the actual surgical and pharmacological strategies used to restore and maintain corneal transparency in terms of long-term survival and geographic coverage. In addition, we critically review the perspectives of anabolic agents, including vitamin A, hormones, growth factors, and novel promitotic and anti-inflammatory modulators, to assist corneal wound healing. We discuss the studies involving nanotechnology, gene therapy, and t...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Anterior segment parameters in patients with coronavirus disease
ABSTRACT This review is intended to describe the therapeutic approaches for corneal blindness, detailing the steps and elements involved in corneal wound healing. It also presents the limitations of the actual surgical and pharmacological strategies used to restore and maintain corneal transparency in terms of long-term survival and geographic coverage. In addition, we critically review the perspectives of anabolic agents, including vitamin A, hormones, growth factors, and novel promitotic and anti-inflammatory modulators, to assist corneal wound healing. We discuss the studies involving nanotechnology, gene therapy, and t...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Surgical approach for lens extraction from a crowded anterior segment
ABSTRACT This review is intended to describe the therapeutic approaches for corneal blindness, detailing the steps and elements involved in corneal wound healing. It also presents the limitations of the actual surgical and pharmacological strategies used to restore and maintain corneal transparency in terms of long-term survival and geographic coverage. In addition, we critically review the perspectives of anabolic agents, including vitamin A, hormones, growth factors, and novel promitotic and anti-inflammatory modulators, to assist corneal wound healing. We discuss the studies involving nanotechnology, gene therapy, and t...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Impact of Coronavirus Disease on the Ophthalmology Residency Training in Brazil
ABSTRACT This review is intended to describe the therapeutic approaches for corneal blindness, detailing the steps and elements involved in corneal wound healing. It also presents the limitations of the actual surgical and pharmacological strategies used to restore and maintain corneal transparency in terms of long-term survival and geographic coverage. In addition, we critically review the perspectives of anabolic agents, including vitamin A, hormones, growth factors, and novel promitotic and anti-inflammatory modulators, to assist corneal wound healing. We discuss the studies involving nanotechnology, gene therapy, and t...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Limitations and advances in new treatments and future perspectives of corneal blindness
ABSTRACT This review is intended to describe the therapeutic approaches for corneal blindness, detailing the steps and elements involved in corneal wound healing. It also presents the limitations of the actual surgical and pharmacological strategies used to restore and maintain corneal transparency in terms of long-term survival and geographic coverage. In addition, we critically review the perspectives of anabolic agents, including vitamin A, hormones, growth factors, and novel promitotic and anti-inflammatory modulators, to assist corneal wound healing. We discuss the studies involving nanotechnology, gene therapy, and t...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

A case of late-onset Klebsiella oxytoca keratitis treated with topical imipenem after deep anterior lamellar keratoplasty
ABSTRACT The aim of this study was to discuss a case of late-onset Klebsiella oxytoca keratitis after deep anterior lamellar keratoplasty and its treatment. A 21-year-old female patient presented with redness and effluence in the left eye at 5 months after uncomplicated deep anterior lamellar keratoplasty surgery. In the examination, a single suture was loosened in the superior nasal region and there was an infiltration area and epithelial defect in the graft and recipient bed junction in the area of the loose suture. Topical fortified vancomycin and fortified ceftazidime treatment was started empirically hourly, but there...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Pseudoexfoliation syndrome in a 27-year-old patient: a case report
ABSTRACT Pseudoexfoliation syndrome is more frequent in people aged>50 yeears, and its prevalence increases with age. Few reports have described cases in younger patients, all with a history of ocular surgery, especially iris resection. Herein, we describe the case of a 27-year old man with bilateral advanced glaucoma and pseudoexfoliation material in OS. He had undergone cataract surgeries OU and a penetrating keratoplasty OD during childhood. Currently, he presented with an intraocular pressure of 40 mmHg OU. The OS showed a white flaky material in the pupillary rim and anterior capsule and a Sampaolesi line as a goni...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Morphologic and molecular study on the lens anterior capsule in systemic sclerosis
This study aimed to analyze the anterior lens capsule specimens from both eyes of a patient with systemic sclerosis and compare them to the eyes of a control patient. No significant differences between systemic sclerosis and control eyes were observed in the results from the hematoxylin-eosin and picrosirius staining. In the samples obtained from both systemic sclerosis and control eyes, there were expressions of caspase, a molecule expressed in cell death by apoptosis. Heparanase was overexpressed in the systemic sclerosis sample compared to the control sample. Therefore, the anterior lens capsule of the patient with syst...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Unnoticed metallic foreign body in the camerular angle inducing chronic uveitis
We report the case of an eight-year-old male patient with a four-month history of unilateral anterior chronic uveitis, associated with a pigmented lesion surrounded by fibrinoid material in the inferior camerular angle and with a fibrotic lesion in the extreme periphery of the inferior retina. The patient had no history of trauma or any other clinical symptoms. Although the patient was suspected of having toxocariasis, serological tests were negative. Partial symptomatic improvement was achieved using both orally and topically administered corticosteroids. In addition, a decrease in fibrinoid material around the pigmented ...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Fluorofenidone inhibits epithelial-mesenchymal transition in human lens epithelial cell line FHL 124: a promising therapeutic strategy against posterior capsular opacification
Conclusions: Fluorofenidone significantly inhibited expression of SMADs, CTGF, α -SMA, COL-I, and Fn in FHL 124 cells. Due to noncompliance in infants, fluorofenidone may become a novel therapeutic drug against posterior capsular opacification in infants.RESUMO Objetivo: Investigar o efeito inibidor da fluorofenidona contra a prolifera ção e a transição epitélio-mesenquimal induzida pelo fator de transformação do crescimento β 2 na linha HLEC FHL 124 e seu mecanismo potencial. M étodos: Avaliou-se o efeito in vitro da fluorofenidona na proliferação e na transição epitelial-mesenquimal da linha FHL 124 de c...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Association between the L55M and Q192R polymorphisms of the paraoxonase-1 gene and age-related macular degeneration: a meta-analysis
Conclusions: The paraoxonase-1L55M polymorphism increases the risk of developing age-related macular degeneration in non-Asian populations, whereas in Asian populations, the polymorphism exerts a protective effect. However, for the paraoxonase-1 Q192R polymorphism, only the Asian population demonstrated a risk of developing age-related macular degeneration.RESUMO Objetivo: A atividade da paraoxonase1 est á associada à degeneração macular relacionada à idade. Dois polimorfismos (L55M e Q192R) mostraram aumentar a atividade da paraoxonase1 e foram implicados no desenvolvimento da degeneração macular relacionada à id...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Expression of Vitamin D Receptor and Vitamin D Receptor Gene Polymorphisms (BsmI, FokI, and TaqI) in Patients with Pterygium
Conclusions: Vitamin D serum levels did not differ between the healthy and pterygium groups. Vitamin D receptor expression was increased in the pterygium tissue versus the adjacent healthy tissue. However, vitamin D receptor polymorphism analysis in patients with pterygium did not reveal any significant difference in BsmI, FokI, or TaqI polymorphisms in comparison with the healthy volunteers.RESUMO Objetivo: Determinar o papel do receptor da vitamina D na patog ênese do pterígio. Os níveis de expressão do receptor da vitamina D no tecido do pterígio, os níveis sanguíneos de vitamina D e a frequência de alguns poli...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Optical coherence tomography angiography findings in patients with ocular and non-ocular Behcet disease
Conclusion: Beh çet disease with posterior uveitis was associated with significant perifoveal and parafoveal vascular decrements in the superficial and deep retina.RESUMO Objetivo: Avaliar achados de angiografia por tomografia de coer ência óptica em pacientes com doença de Behçet com e sem acometimento ocular. Métodos: Foram incluídos 40 pacientes com doença de Behçet e 30 controles saudáveis. A densidade vascular retiniana nos plexos capilares superficial e profundo, a zona avascular foveal, o índice de circularidade , a densidade foveal e a área sem fluxo da retina superficial foram medidos automaticamente...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research

Use of viscoelastic substance for preventing Descemet’s membrane rupture in deep anterior lamellar keratoplasty
Conclusions: Administering a viscoelastic substance onto the posterior stromal side just before puncture is an effective method to decrease the risk of Descemet ’ s membrane perforation in deep anterior lamellar keratoplasty.RESUMO Objetivo: Investigar o efeito do uso de uma subst ância viscoelástica na ruptura da membrana de Descemet em casos de ceratoplastia lamelar anterior profunda em “ bolha dupla ” . M étodos: Foram avaliados retrospectivamente prontuários e vídeos de cirurgias de 40 pacientes operados entre janeiro de 2014 e julho de 2015. Os pacientes foram divididos em dois grupos: 20 pacientes nos qu...
Source: Arquivos Brasileiros de Oftalmologia - May 22, 2021 Category: Opthalmology Source Type: research