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The Interplay Between Human Leukocyte Antigen Antibody Profile and COVID-19 Vaccination in Waitlisted Renal Transplant Patients
CONCLUSIONS.—: Our data suggest that COVID-19 vaccination propagates anti-HLA class I and II antibodies for waitlisted renal transplant patients. The clinical significance of these antibodies needs further study. Furthermore, comorbidities, such as history of COVID-19 infection and hypertension, supplemented this effect. Anti-HLA antibody monitoring may be warranted in vaccinated, waitlisted renal transplant patients with COVID-19 vaccinations, and a history of COVID-19 infection or hypertension.PMID:38599589 | DOI:10.5858/arpa.2023-0370-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Yayuan Zhao Pramath Kakodkar Henry Pan Richard Zhu Khalid Musa Abubaker Hassan Ahmed Shoker Destinie Webster Twyla Pearce Pouneh Dokouhaki Fang Wu Ahmed Mostafa Source Type: research

Ten Years of Pathology on Twitter (X): Landscape and Evolution of Pathology on Twitter From 2012 to 2023
CONCLUSIONS.—: Pathology Twitter has grown during the last 10 years and has become increasingly popular for pathology education and networking. With the changing landscape of social media platforms this study provides an understanding of how pathology medical education and professional networking uses of social media are used and evolve over time.PMID:38599590 | DOI:10.5858/arpa.2023-0447-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 10, 2024 Category: Laboratory Medicine Authors: Roland Tian Eric Wang Priyadharshini Sivasubramaniam Swikrity U Baskota Anurag Sharma Matthew J Cecchini Source Type: research

Guidelines for Pathologic Diagnosis of Mesothelioma
CONCLUSIONS.—: There was consensus opinion regarding guidelines for (1) histomorphologic diagnosis of mesothelial tumors, including distinction of epithelioid, biphasic, and sarcomatoid mesothelioma; recognition of morphologic variants and patterns; and recognition of common morphologic pitfalls; (2) molecular pathogenesis of mesothelioma; (3) application of immunohistochemical markers to establish mesothelial lineage and distinguish mesothelioma from common morphologic differentials; (4) application of ancillary studies to distinguish benign from malignant mesothelial proliferations, including BAP1 and MTAP immunostains...
Source: Archives of Pathology and Laboratory Medicine - April 8, 2024 Category: Laboratory Medicine Authors: Aliya N Husain David B Chapel Richard Attanoos Mary Beth Beasley Luka Brcic Kelly Butnor Lucian R Chirieac Andrew Churg Sanja Dacic Francoise Galateau-Salle Kenzo Hiroshima Yin P Hung Sonja Klebe Thomas Krausz Andras Khoor Leslie Litzky Alberto Marchevsky Source Type: research

Therapeutic Drug Monitoring of 6 New-Generation Antiseizure Medications Using a Mass Spectrometry Method: Analysis of 2-Year Experience in a Large Cohort of Korean Epilepsy Patients
CONCLUSIONS.—: A simple and rapid LC-MS/MS method for TDM of 6 ASMs was developed and successfully applied to clinical practice. This large-scale TDM data could help establish an effective monitoring strategy for these drugs.PMID:38576184 | DOI:10.5858/arpa.2023-0386-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Sang-Mi Kim Won Young Heo Hyeonju Oh Eun Yeon Joo Young-Min Shon Seung Bong Hong Soo-Youn Lee Dae-Won Seo Source Type: research

Is Fragmentation of Prostate Core Biopsies Inevitable? A Quality Improvement Initiative
CONCLUSIONS.—: Submission of >1 biopsy core per jar and use of Telfa for mounting are associated with increased fragmentation. We recommend limiting submission to 1 core per jar and avoid mounting on Telfa pads.PMID:38576208 | DOI:10.5858/arpa.2023-0492-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Krithika Shenoy Richard J Cote Gayathri Kini Mary Anthes-Bartlow Vijayalakshmi Padmanabhan Source Type: research

Clinically Undiagnosed Diseases in Autopsies: Frequency and Risk Factors
CONCLUSIONS.—: Autopsy is a useful investigation for the detection of clinically undiagnosed entities. In our cohort, cardiac amyloidosis showed the highest number of underlying risk factors, but was clinically underdiagnosed. Our findings underline the necessity of improved clinical detection of cardiac amyloidosis, especially in light of emerging therapeutic options. Moreover, we characterize the most common entities prone to clinical underdiagnosis.PMID:38576236 | DOI:10.5858/arpa.2023-0429-OA (Source: Archives of Pathology and Laboratory Medicine)
Source: Archives of Pathology and Laboratory Medicine - April 5, 2024 Category: Laboratory Medicine Authors: Umberto Maccio Christoph Andreas Meier Michael Reinehr Frank Ruschitzka Reto Sch üpbach Holger Moch Zsuzsanna Varga Source Type: research