American Journal of Physiology. Endocrinology and Metabolism This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Hepatic lipid droplet-associated proteome changes distinguish dietary-induced fatty liver from glucose tolerance in male mice
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00013.2024. Online ahead of print.ABSTRACTFatty liver is characterized by the expansion of lipid droplets (LDs) and is associated with the development of many metabolic diseases. We assessed the morphology of hepatic LDs and performed quantitative proteomics in lean, glucose-tolerant mice compared to high-fat diet (HFD) fed mice that displayed hepatic steatosis and glucose intolerance as well as high-starch diet (HStD) fed mice who exhibited similar levels of hepatic steatosis but remained glucose tolerant. Both HFD and HStD-fed mice had more and larger LDs t...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Andries Van Woerkom Dylan J Harney Shilpa R Nagarajan Mariam F Hakeem-Sanni Jinfeng Lin Matthew Hooke Tamara Pilpitel Gregory J Cooney Mark Larance Darren N Saunders Amanda E Brandon Andrew J Hoy Source Type: research

Chronic Pancreatitis-Associated Metabolic Bone Diseases: Epidemiology, Mechanisms, and Clinical Advances
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00113.2024. Online ahead of print.ABSTRACTChronic pancreatitis (CP) is a progressive inflammatory disease with an increasing global prevalence. In recent years, a strong association between CP and metabolic bone diseases (MBDs), especially osteoporosis, has been identified, attracting significant attentions in the research field. Epidemiological data suggest a rising trend in the incidence of MBDs among CP patients. Notably, recent studies have highlighted a profound interplay between CP and altered nutritional and immune profiles, offering insights into its ...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Tianlin Wang Ke Xiong Yanli He Binbin Feng Linbin Guo Jingliang Gu Hong Wang Xiaohao Wu Source Type: research

< em > TAF1 < /em > is needed for the proliferation and maturation of thyroid follicle cells < em > via < /em > Notch signaling
This study showed that TAF1 promoted Notch signaling and that this association played a pivotal role in thyroid development.PMID:38656129 | DOI:10.1152/ajpendo.00403.2023 (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Caoxu Zhang Liu Yang Haiyang Zhang Fengyao Wu Yue Zhang Kaiwen Zhang Chenyang Wu Rui Li Mei Dong Shuangxia Zhao Huaidong Song Source Type: research

Phosphorylation of AS160-Serine 704 is Not Essential for Exercise-increase in Insulin-stimulated Glucose Uptake by Skeletal Muscles from Female or Male Rats
Am J Physiol Endocrinol Metab. 2024 Apr 24. doi: 10.1152/ajpendo.00010.2024. Online ahead of print.ABSTRACTOne exercise session can increase subsequent insulin-stimulated glucose uptake (ISGU) by skeletal muscle from rodents and humans of both sexes. We recently found that concurrent mutation of three key sites to prevent their phosphorylation (Ser588, Thr642, and Ser704) on Akt substrate of 160 kDa (AS160; also known as TBC1D4) reduced the magnitude of the enhancement of postexercise ISGU (PEX-ISGU) by muscle from male, but not female rats. However, we did not test the role of individual phosphorylation sites on PEX-ISGU....
Source: American Journal of Physiology. Endocrinology and Metabolism - April 24, 2024 Category: Physiology Authors: Haiyan Wang Seong Eun Kwak Amy Zheng Edward B Arias Xiufang Pan Dongsheng Duan Gregory D Cartee Source Type: research

Mechanisms of spinophilin-dependent pancreas dysregulation in obesity
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00099.2023. Online ahead of print.ABSTRACTSpinophilin is an F-actin binding and protein phosphatase 1 (PP1) targeting protein that acts as a scaffold of PP1 to its substrates. Spinophilin knockout (Spino-/-) mice have decreased fat mass, increased lean mass, and improved glucose tolerance, with no difference in feeding behaviors. While spinophilin is enriched in neurons, its roles in non-neuronal tissues, such as beta cells of the pancreatic islets, are unclear. We have corroborated and expanded upon previous studies to determine that Spino-/- mice have decre...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Kaitlyn C Stickel Nikhil R Shah Emily T Claeboe Kara S Orr Amber L Mosley Emma H Doud Teri L Belecky-Adams Anthony J Baucum Source Type: research

Advancements in Diabetic Kidney Disease Management: Integrating Innovative Therapies and Targeted Drug Development
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00026.2024. Online ahead of print.ABSTRACTDiabetic kidney disease (DKD) is a leading cause of chronic kidney disease and affects approximately 40% of diabetic individuals. Cases of DKD continue to rise globally as the prevalence of diabetes mellitus increases, with an estimated 415 million people living with diabetes in 2015 and a projected 642 million by 2040. DKD is associated with significant morbidity and mortality, representing 34% and 36% of all chronic kidney disease deaths in men and women, respectively. Common co-morbidities including hypertension an...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Shaarav Ghose Matthew Satariano Saichidroopi Korada Thomas Cahill Raghav Shah Rupesh Raina Source Type: research

Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00327.2023. Online ahead of print.ABSTRACTOne-anastomosis gastric bypass (OAGB) has gained importance as a safe and effective operation to treat morbid obesity. It is not known whether a long biliopancreatic limb (BPL) in OAGB surgery compared to a short BPL results in beneficial metabolic outcomes. 5-week-old male C57BL/6J mice fed a high-fat diet for 8 weeks underwent OAGB surgery with defined short and long BPL lengths, or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut m...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Ioannis I Lazaridis Angela J T Bosch Lena Keller Andy J Y Low Jeanne Tamarelle Seraina O Moser Denise V Winter Cristina G ómez Caspar J Peterson Romano Schneider Marko Kraljevi ć Alex Odermatt Pascale Vonaesch Ralph Peterli Tarik Delko Claudia Cavelti-W Source Type: research

Metabolic outcomes in obese mice undergoing one-anastomosis gastric bypass (OAGB) with a long or a short biliopancreatic limb
Am J Physiol Endocrinol Metab. 2024 Apr 17. doi: 10.1152/ajpendo.00327.2023. Online ahead of print.ABSTRACTOne-anastomosis gastric bypass (OAGB) has gained importance as a safe and effective operation to treat morbid obesity. It is not known whether a long biliopancreatic limb (BPL) in OAGB surgery compared to a short BPL results in beneficial metabolic outcomes. 5-week-old male C57BL/6J mice fed a high-fat diet for 8 weeks underwent OAGB surgery with defined short and long BPL lengths, or sham surgery combined with caloric restriction. Weight loss, glucose tolerance, obesity-related comorbidities, endocrine effects, gut m...
Source: American Journal of Physiology. Endocrinology and Metabolism - April 17, 2024 Category: Physiology Authors: Ioannis I Lazaridis Angela J T Bosch Lena Keller Andy J Y Low Jeanne Tamarelle Seraina O Moser Denise V Winter Cristina G ómez Caspar J Peterson Romano Schneider Marko Kraljevic Alex Odermatt Pascale Vonaesch Ralph Peterli Tarik Delko Claudia Cavelti-Wed Source Type: research

Corrigendum for Subramanian et al., volume 326, 2024, p. E182-E205
Am J Physiol Endocrinol Metab. 2024 Apr 1;326(4):E545. doi: 10.1152/ajpendo.00278.2023_COR.NO ABSTRACTPMID:38619308 | DOI:10.1152/ajpendo.00278.2023_COR (Source: American Journal of Physiology. Endocrinology and Metabolism)
Source: American Journal of Physiology. Endocrinology and Metabolism - April 15, 2024 Category: Physiology Source Type: research