Is the automated Elecsys tacrolimus assay on the Roche cobas e 602 analyzer an acceptable replacement for a liquid chromatography-tandem mass spectrometry-based assay?
CONCLUSIONS: The 2 major challenges for implementation of the tacrolimus ECLIA assay are the postextraction sample stability and the significant proportional bias observed compared with the LC-MS/MS reference method. The 30-minute window for analysis of extracted samples is a practical challenge to the routine workflow of the core laboratory. In addition, disagreement between the immunoassay and LC-MS/MS methods can lead to discordant clinical interpretations and ultimately affect patient care.PMID:37724434 | DOI:10.1093/ajcp/aqad114 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 19, 2023 Category: Pathology Authors: Anastasia Gant Kanegusuku Kiang-Teck J Yeo Source Type: research

Is the automated Elecsys tacrolimus assay on the Roche cobas e 602 analyzer an acceptable replacement for a liquid chromatography-tandem mass spectrometry-based assay?
CONCLUSIONS: The 2 major challenges for implementation of the tacrolimus ECLIA assay are the postextraction sample stability and the significant proportional bias observed compared with the LC-MS/MS reference method. The 30-minute window for analysis of extracted samples is a practical challenge to the routine workflow of the core laboratory. In addition, disagreement between the immunoassay and LC-MS/MS methods can lead to discordant clinical interpretations and ultimately affect patient care.PMID:37724434 | DOI:10.1093/ajcp/aqad114 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 19, 2023 Category: Pathology Authors: Anastasia Gant Kanegusuku Kiang-Teck J Yeo Source Type: research

Implementation and assessment of an electronic clinical decision support tool to notify clinicians of critical hyperbilirubinemia in preterm neonates less than 35 weeks' gestation
CONCLUSIONS: The electronic CDS tool promoted more appropriate and timely intervention orders to manage critical hyperbilirubinemia in preterm neonates.PMID:37698998 | DOI:10.1093/ajcp/aqad112 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 12, 2023 Category: Pathology Authors: Yi Xiao Mandy Palmucc Lance Carlin Catherine Lee Maurice R G O'Gorman Srikumar Nair Leah Yieh Edward Ki-Yun Leung Source Type: research

Implementation and assessment of an electronic clinical decision support tool to notify clinicians of critical hyperbilirubinemia in preterm neonates less than 35 weeks' gestation
CONCLUSIONS: The electronic CDS tool promoted more appropriate and timely intervention orders to manage critical hyperbilirubinemia in preterm neonates.PMID:37698998 | DOI:10.1093/ajcp/aqad112 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 12, 2023 Category: Pathology Authors: Yi Xiao Mandy Palmucc Lance Carlin Catherine Lee Maurice R G O'Gorman Srikumar Nair Leah Yieh Edward Ki-Yun Leung Source Type: research

Implementation and assessment of an electronic clinical decision support tool to notify clinicians of critical hyperbilirubinemia in preterm neonates less than 35 weeks' gestation
CONCLUSIONS: The electronic CDS tool promoted more appropriate and timely intervention orders to manage critical hyperbilirubinemia in preterm neonates.PMID:37698998 | DOI:10.1093/ajcp/aqad112 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 12, 2023 Category: Pathology Authors: Yi Xiao Mandy Palmucc Lance Carlin Catherine Lee Maurice R G O'Gorman Srikumar Nair Leah Yieh Edward Ki-Yun Leung Source Type: research

Implementation and assessment of an electronic clinical decision support tool to notify clinicians of critical hyperbilirubinemia in preterm neonates less than 35 weeks' gestation
CONCLUSIONS: The electronic CDS tool promoted more appropriate and timely intervention orders to manage critical hyperbilirubinemia in preterm neonates.PMID:37698998 | DOI:10.1093/ajcp/aqad112 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 12, 2023 Category: Pathology Authors: Yi Xiao Mandy Palmucc Lance Carlin Catherine Lee Maurice R G O'Gorman Srikumar Nair Leah Yieh Edward Ki-Yun Leung Source Type: research

Implementation and assessment of an electronic clinical decision support tool to notify clinicians of critical hyperbilirubinemia in preterm neonates less than 35 weeks' gestation
CONCLUSIONS: The electronic CDS tool promoted more appropriate and timely intervention orders to manage critical hyperbilirubinemia in preterm neonates.PMID:37698998 | DOI:10.1093/ajcp/aqad112 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 12, 2023 Category: Pathology Authors: Yi Xiao Mandy Palmucc Lance Carlin Catherine Lee Maurice R G O'Gorman Srikumar Nair Leah Yieh Edward Ki-Yun Leung Source Type: research

Implementation and assessment of an electronic clinical decision support tool to notify clinicians of critical hyperbilirubinemia in preterm neonates less than 35 weeks' gestation
CONCLUSIONS: The electronic CDS tool promoted more appropriate and timely intervention orders to manage critical hyperbilirubinemia in preterm neonates.PMID:37698998 | DOI:10.1093/ajcp/aqad112 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 12, 2023 Category: Pathology Authors: Yi Xiao Mandy Palmucc Lance Carlin Catherine Lee Maurice R G O'Gorman Srikumar Nair Leah Yieh Edward Ki-Yun Leung Source Type: research

Novel ALK immunohistochemistry assay (clone OTI1A4, Dako) is a sensitive, reliable marker for identifying ALK rearrangements in lung adenocarcinomas : A validation study
CONCLUSIONS: Immunohistochemistry-based assays provide a valid and reasonably priced alternative, especially in settings where molecular confirmatory tests are neither offered nor accessible. Given high interassay and molecular concordance, we propose that the novel Dako OTI1A4 assay can be reliably used to identify cases with ALK rearrangement.PMID:37681660 | DOI:10.1093/ajcp/aqad111 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 8, 2023 Category: Pathology Authors: Ozgur Can Eren Cisel Aydin Mericoz Emine Bozkurtlar Pinar Bulutay Arzu Baygul Ibrahim Kulac Source Type: research

Novel ALK immunohistochemistry assay (clone OTI1A4, Dako) is a sensitive, reliable marker for identifying ALK rearrangements in lung adenocarcinomas : A validation study
CONCLUSIONS: Immunohistochemistry-based assays provide a valid and reasonably priced alternative, especially in settings where molecular confirmatory tests are neither offered nor accessible. Given high interassay and molecular concordance, we propose that the novel Dako OTI1A4 assay can be reliably used to identify cases with ALK rearrangement.PMID:37681660 | DOI:10.1093/ajcp/aqad111 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 8, 2023 Category: Pathology Authors: Ozgur Can Eren Cisel Aydin Mericoz Emine Bozkurtlar Pinar Bulutay Arzu Baygul Ibrahim Kulac Source Type: research

Novel ALK immunohistochemistry assay (clone OTI1A4, Dako) is a sensitive, reliable marker for identifying ALK rearrangements in lung adenocarcinomas : A validation study
CONCLUSIONS: Immunohistochemistry-based assays provide a valid and reasonably priced alternative, especially in settings where molecular confirmatory tests are neither offered nor accessible. Given high interassay and molecular concordance, we propose that the novel Dako OTI1A4 assay can be reliably used to identify cases with ALK rearrangement.PMID:37681660 | DOI:10.1093/ajcp/aqad111 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 8, 2023 Category: Pathology Authors: Ozgur Can Eren Cisel Aydin Mericoz Emine Bozkurtlar Pinar Bulutay Arzu Baygul Ibrahim Kulac Source Type: research

Novel ALK immunohistochemistry assay (clone OTI1A4, Dako) is a sensitive, reliable marker for identifying ALK rearrangements in lung adenocarcinomas : A validation study
CONCLUSIONS: Immunohistochemistry-based assays provide a valid and reasonably priced alternative, especially in settings where molecular confirmatory tests are neither offered nor accessible. Given high interassay and molecular concordance, we propose that the novel Dako OTI1A4 assay can be reliably used to identify cases with ALK rearrangement.PMID:37681660 | DOI:10.1093/ajcp/aqad111 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 8, 2023 Category: Pathology Authors: Ozgur Can Eren Cisel Aydin Mericoz Emine Bozkurtlar Pinar Bulutay Arzu Baygul Ibrahim Kulac Source Type: research

Superior detection rate of plasma cell FISH using FACS-FISH
CONCLUSIONS: Fluorescence-activated cell sorting-FISH is an efficient PC purification strategy that affords significant improvement in diagnostic yield and decreases workflow requirements in comparison with cIg-FISH.PMID:37658775 | DOI:10.1093/ajcp/aqad108 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 2, 2023 Category: Pathology Authors: Marie-France Gagnon Sally M Midthun James A Fangel Cynthia M Schuh Ivy M Luoma Kathryn E Pearce Reid G Meyer Sikander Ailawadhi Mariano J Arribas Esteban Braggio Rafael Fonseca S Vincent Rajkumar Cinthya Zepeda-Mendoza Xinjie Xu Patricia T Greipp Michael Source Type: research

A fully interpretable machine learning model for increasing the effectiveness of urine screening
CONCLUSIONS: Overall, this study provides an effective and interpretable screening method for urine culture in microbiology laboratories, using data from the Sysmex UF-1000i automated analyzer. Unlike other machine learning models, our model is interpretable, generating trust and enabling real-world implementation.PMID:37658807 | DOI:10.1093/ajcp/aqad099 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 2, 2023 Category: Pathology Authors: Fabio Del Ben Giacomo Da Col Doriana Cob ârzan Matteo Turetta Daniela Rubin Patrizio Buttazzi Antonio Antico Source Type: research

Assessment of a large language model's utility in helping pathology professionals answer general knowledge pathology questions
CONCLUSIONS: ChatGPT version 4.0 gave responses that were predominantly accurate and complete for general knowledge-type pathology questions. With further research and when reviewed by a pathologist or laboratorian, this could facilitate its use as a pathologist's aid in answering questions from health care providers.PMID:37658808 | DOI:10.1093/ajcp/aqad106 (Source: American Journal of Clinical Pathology)
Source: American Journal of Clinical Pathology - September 2, 2023 Category: Pathology Authors: Robert C Benirschke Joshua Wodskow Kritika Prasai Andrew Freeman John M Lee John Groth Source Type: research