N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research
N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research
N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research
N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research
N-Acetyl Cysteine as an Add-on Therapy is Useful in Treating Acute Lumbar Radiculopathy Caused by Disc Herniation: Results of a Randomized, Controlled Clinical Trial
CONCLUSIONS: This study suggested that NAC might be a relevant candidate for adjunct therapy in managing acute lumbar radiculopathy. Additional clinical trials are needed to validate these findings.TRIAL REGISTRATION: The trial was registered at Clinicaltrials.gov (identifier code: IRCT2012021 5009014N381). Registration date: 2021-02-06.PMID:37779397 | DOI:10.2174/0115748871250545230919055109 (Source: Reviews on Recent Clinical Trials)
Source: Reviews on Recent Clinical Trials - October 2, 2023 Category: Cancer & Oncology Authors: Bijan Heidari Zeinab-Alsadat Seyedian Maryam Mehrpooya Davoud Ahmadimoghaddam Mahtabalsadat Mirjalili Masood Ghiasian Source Type: research
Blot Clot Risk Higher When Pain Relievers Used With Hormonal Contraception
Using over-the-counter pain relievers known as nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac, ibuprofen, and naproxen alongside hormonal contraception was tied to a higher chance of developing blood clots, also known as venous thromboembolism, according to data collected from about 2 million women in Denmark between 1996 and 2017. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - September 20, 2023 Category: General Medicine Source Type: research
Effective photocatalytic degradation of amphotericin B and naproxen from aqueous solutions using carbon quantum dots combined in MIL-88B(Fe) under visible light
Chemosphere. 2023 Sep 14:140155. doi: 10.1016/j.chemosphere.2023.140155. Online ahead of print.ABSTRACTA photocatalytic adsorbent composed of carbon dots (CD) embedded in a metal-organic framework (MOF) of MIL-88 B(Fe) was prepared by solvothermal technique. The synthesized CD@MIL-88 B(Fe) was characterized by different X-ray-based microscopic and spectroscopic methods, as well as electrochemical impedance spectroscopy, UV-Vis, FT-IR, DRS, TGA, and photoluminescence (PL) analysis. The prepared adsorbent showed a remarkable photocatalytic activity for eliminating amphotericin B (AmB) and naproxen (Nap) from aqueous solution...
Source: Chemosphere - September 16, 2023 Category: Chemistry Authors: Fateme Firoozbakht Gholamhassan Azimi Shahram Tangestaninejad Payam Hayati Source Type: research
Effective photocatalytic degradation of amphotericin B and naproxen from aqueous solutions using carbon quantum dots combined in MIL-88B(Fe) under visible light
Chemosphere. 2023 Sep 14:140155. doi: 10.1016/j.chemosphere.2023.140155. Online ahead of print.ABSTRACTA photocatalytic adsorbent composed of carbon dots (CD) embedded in a metal-organic framework (MOF) of MIL-88 B(Fe) was prepared by solvothermal technique. The synthesized CD@MIL-88 B(Fe) was characterized by different X-ray-based microscopic and spectroscopic methods, as well as electrochemical impedance spectroscopy, UV-Vis, FT-IR, DRS, TGA, and photoluminescence (PL) analysis. The prepared adsorbent showed a remarkable photocatalytic activity for eliminating amphotericin B (AmB) and naproxen (Nap) from aqueous solution...
Source: Chemosphere - September 16, 2023 Category: Chemistry Authors: Fateme Firoozbakht Gholamhassan Azimi Shahram Tangestaninejad Payam Hayati Source Type: research
Drug Repurposing for Spinal Cord Injury: Progress Towards Therapeutic Intervention for Primary Factors and Secondary Complications
AbstractSpinal cord injury (SCI) encompasses a plethora of complex mechanisms like the involvement of major cell death pathways, neurodegeneration of spinal cord neurons, overexpression of glutaminergic transmission and inflammation cascade, along with different co-morbidities like neuropathic pain, urinary and sexual dysfunction, respiratory and cardiac failures, making it one of the leading causes of morbidity and mortality globally. Corticosteroids such as methylprednisolone and dexamethasone, and non-steroidal anti-inflammatory drugs such as naproxen, aspirin and ibuprofen are the first-line treatment options for SCI, ...
Source: Pharmaceutical Medicine - September 12, 2023 Category: Drugs & Pharmacology Source Type: research
Fabrication of a bifunctional fluorescent chiral composite based on magnetic Fe < sub > 3 < /sub > O < sub > 4 < /sub > /chiral carbon dots@hierarchical porous metal-organic framework
Talanta. 2023 Aug 28;266(Pt 2):125113. doi: 10.1016/j.talanta.2023.125113. Online ahead of print.ABSTRACTConsidering the selective pharmacological activity and ecotoxicity of chiral drugs, the development of chiral materials with the dual functions of enantiomeric recognition and adsorption is of great significance. Herein, a novel bifunctional chiral composite (Fe3O4/CCDs@HP-ZIF-8) which does not contain expensive and rare fluorescent chiral ligands or metal ions, was constructed for the first time by encapsulating chiral carbon dots (CCDs) and magnetic Fe3O4 nanoparticles into hierarchical porous metal-organic frameworks...
Source: Talanta - August 31, 2023 Category: Chemistry Authors: Min Wang Meiling Zhou Min Wang Jiayin Du Chunlan Liu Yue Wang Zhining Xia Source Type: research
Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
CONCLUSION: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates.PMID:37646067 | PMC:PMC10460805 | DOI:10.34172/apb.2023.066 (Source: Adv Data)
Source: Adv Data - August 30, 2023 Category: Epidemiology Authors: Elnaz Shaseb Saba Ghaffary Alireza Garjani Elnaz Zoghi Nasrin Maleki Dizaji Somaieh Soltani Parvin Sarbakhsh Mohammad Hossein Somi Parya Valizadeh Ali Taghizadieh Masood Faghihdinevari Mojtaba Varshochi Behrooz Naghily Zhinous Bayatmakoo Parviz Saleh Sepe Source Type: research
Long and Short-term Metformin Consumption as a Potential Therapy to Prevent Complications of COVID-19
CONCLUSION: In this trial, metformin consumption had no effect on mortality and ICU admission rates in non-diabetic patients. However, metformin improved COVID-19 complications in diabetic patients who had been receiving metformin prior to COVID-19 infection, and it significantly lowered the intubation rates.PMID:37646067 | PMC:PMC10460805 | DOI:10.34172/apb.2023.066 (Source: Adv Data)
Source: Adv Data - August 30, 2023 Category: Epidemiology Authors: Elnaz Shaseb Saba Ghaffary Alireza Garjani Elnaz Zoghi Nasrin Maleki Dizaji Somaieh Soltani Parvin Sarbakhsh Mohammad Hossein Somi Parya Valizadeh Ali Taghizadieh Masood Faghihdinevari Mojtaba Varshochi Behrooz Naghily Zhinous Bayatmakoo Parviz Saleh Sepe Source Type: research
Evidence-based clinical practice guideline for the pharmacologic management of acute dental pain in children: A report from the American Dental Association Science and Research Institute, the University of Pittsburgh School of Dental Medicine, and the Center for Integrative Global Oral Health at the University of Pennsylvania
CONCLUSIONS AND PRACTICAL IMPLICATIONS: Nonopioid medications, specifically nonsteroidal anti-inflammatory drugs like ibuprofen and naproxen alone or in combination with acetaminophen, are recommended for managing acute dental pain after 1 or more tooth extractions (that is, simple and surgical) and the temporary management of toothache in children (conditional recommendation, very low certainty). According to the US Food and Drug Administration, the use of codeine and tramadol in children for managing acute pain is contraindicated.PMID:37634915 | DOI:10.1016/j.adaj.2023.06.014 (Source: Journal of the American Dental Association)
Source: Journal of the American Dental Association - August 27, 2023 Category: Dentistry Authors: Alonso Carrasco-Labra Deborah E Polk Olivia Urquhart Tara Aghaloo J William Claytor Vineet Dhar Raymond A Dionne Lorena Espinoza Sharon M Gordon Elliot V Hersh Alan S Law Brian S-K Li Paul J Schwartz Katie J Suda Michael A Turturro Marjorie L Wright Tim D Source Type: research
P003/32 Traumatic cervical carotid dissection in association with fractured elongated styloid process
PresentationA 22 year old male with no comorbidities presented with a witnessed collapse, dysconjugate eye movements, dysarthria, right-sided head and neck (H&N) pain with contralateral hemiplegia and facial droop (NIHSS 14).CTH and angio showed right ICA dissection just beyond its origin causing complete occlusion. A thrombus was present at the right M1. There was partial patency in this region and in distal MCA branches with collateral supply from the ACAs-AComm.InterventionThrombolysis was performed but terminated with 1 ml tPA remaining due to patient deterioration (NIHSS 20). Repeat CTH showed evolving right middl...
Source: Journal of NeuroInterventional Surgery - August 21, 2023 Category: Neurosurgery Authors: Roberts, S., Jain, A., Islim, F., Nejadhamzeeigilani, H., Patankar, T., Prasai, A., Idrovo, L., Deniz, K. Tags: 4.2 CASE PROPOSAL - Brain AVM/AVF, spinal vascular malformations Source Type: research
